scholarly journals Biomarker evaluation under imperfect nested case‐control design

2021 ◽  
Author(s):  
Xuan Wang ◽  
Yingye Zheng ◽  
Majken Karoline Jensen ◽  
Zeling He ◽  
Tianxi Cai
Keyword(s):  
Control Design ◽  
Case Control ◽  
Biomarker Evaluation ◽  
Nested Case Control

scholarly journals Application of the matched nested case-control design to the secondary analysis of trial data

2020 ◽  
Author(s):  
Christopher Partlett ◽  
Nigel J Hall ◽  
Alison Leaf ◽  
Edmund Juszczak ◽  
Louise Linsell
Keyword(s):  
Clinical Trial ◽  
Case Control Study ◽  
Secondary Analysis ◽  
Control Design ◽  
Case Control ◽  
Necrotising Enterocolitis ◽  
Trial Data ◽  
Standard Case ◽  
Nested Case Control ◽  
Control Study

Abstract Background A nested case-control study is an efficient design that can be embedded within an existing cohort study or randomised trial. It has a number of advantages compared to the conventional case-control design, and has the potential to answer important research questions using untapped prospectively collected data. Methods We demonstrate the utility of the matched nested case-control design by applying it to a secondary analysis of the Abnormal Doppler Enteral Prescription Trial. We investigated the role of milk feed type and changes in milk feed type in the development of necrotising enterocolitis in a group of 398 high risk growth-restricted preterm infants. Results Using matching, we were able to generate a comparable sample of controls selected from the same population as the cases. In contrast to the standard case-control design, exposure status was ascertained prior to the outcome event occurring and the comparison between the cases and matched controls could be made at the point at which the event occurred. This enabled us to reliably investigate the temporal relationship between feed type and necrotising enterocolitis. Conclusions A matched nested case-control study can be used to identify credible associations in a secondary analysis of clinical trial data where the exposure of interest was not randomised, and has several advantages over a standard case-control design. This method offers the potential to make reliable inferences in scenarios where it would be unethical or impractical to perform a randomised clinical trial.

scholarly journals Food consumption and advanced β cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes: a nested case-control design

2012 ◽  
Vol 95 (2) ◽  
pp. 471-478 ◽  
Author(s):  
Suvi M Virtanen ◽  
Jaakko Nevalainen ◽  
Carina Kronberg-Kippilä ◽  
Suvi Ahonen ◽  
Heli Tapanainen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Children ◽  
Food Consumption ◽  
Control Design ◽  
Case Control ◽  
Β Cell ◽  
Nested Case Control

scholarly journals Application of the matched nested case-control design to the secondary analysis of trial data

2019 ◽  
Author(s):  
Christopher Partlett ◽  
Nigel J Hall ◽  
Alison Leaf ◽  
Edmund Juszczak ◽  
Louise Linsell
Keyword(s):  
Clinical Trial ◽  
Case Control Study ◽  
Randomised Trial ◽  
Secondary Analysis ◽  
Control Design ◽  
Case Control ◽  
Trial Data ◽  
Standard Case ◽  
Nested Case Control ◽  
Control Study

Abstract Background: A nested case-control study is an efficient design that can be embedded within an existing cohort study or randomised trial. It has a number of advantages compared to the conventional case-control design, and has the potential to answer important research questions using untapped prospectively collected data.Methods: We demonstrate the utility of the matched nested case-control design by applying it to a secondary analysis of the Abnormal Doppler Enteral Prescription Trial. We investigated the role of milk feed type and changes in milk feed type in the development of necrotising enterocolitis in a group of 398 high risk growth-restricted preterm infants. Results: Using matching, we were able to generate a comparable sample of controls selected from the same population as the cases. In contrast to the standard case-control design, exposure status was ascertained prior to the outcome event occurring and the comparison between the cases and matched controls could be made at the point at which the event occurred. This enabled us to reliably investigate the temporal relationship between feed type and NEC. Conclusions: A matched nested case-control study can be used to identify credible associations in a secondary analysis of clinical trial data where the exposure of interest was not randomised, and has several advantages over a standard case-control design. This method offers the potential to make reliable inferences in scenarios where it would be unethical or impractical to perform a randomised clinical trial.

scholarly journals Advantages of the nested case-control design in diagnostic research

2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Cornelis J Biesheuvel ◽  
Yvonne Vergouwe ◽  
Ruud Oudega ◽  
Arno W Hoes ◽  
Diederick E Grobbee ◽  
...  
Keyword(s):  
Control Design ◽  
Case Control ◽  
Diagnostic Research ◽  
Nested Case Control
Sign in / Sign up

Export Citation Format

Share Document