Simultaneous modeling of Alzheimer's disease progression via multiple cognitive scales

2021 ◽  
Author(s):  
Line Kühnel ◽  
Anna‐Karin Berger ◽  
Bo Markussen ◽  
Lars L. Raket
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Simultaneous Modeling

scholarly journals Disease progression modelling from preclinical Alzheimer’s disease (AD) to AD dementia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Soo Hyun Cho ◽  
Sookyoung Woo ◽  
Changsoo Kim ◽  
Hee Jin Kim ◽  
Hyemin Jang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Disease Assessment ◽  
Time Interval ◽  
Disease Course ◽  
Preclinical Alzheimer’S Disease ◽  
Apoe Ε4 ◽  
Preclinical Ad ◽  
Cognitive Subscale

AbstractTo characterize the course of Alzheimer’s disease (AD) over a longer time interval, we aimed to construct a disease course model for the entire span of the disease using two separate cohorts ranging from preclinical AD to AD dementia. We modelled the progression course of 436 patients with AD continuum and investigated the effects of apolipoprotein E ε4 (APOE ε4) and sex on disease progression. To develop a model of progression from preclinical AD to AD dementia, we estimated Alzheimer’s Disease Assessment Scale-Cognitive Subscale 13 (ADAS-cog 13) scores. When calculated as the median of ADAS-cog 13 scores for each cohort, the estimated time from preclinical AD to MCI due to AD was 7.8 years and preclinical AD to AD dementia was 15.2 years. ADAS-cog 13 scores deteriorated most rapidly in women APOE ε4 carriers and most slowly in men APOE ε4 non-carriers (p < 0.001). Our results suggest that disease progression modelling from preclinical AD to AD dementia may help clinicians to estimate where patients are in the disease course and provide information on variation in the disease course by sex and APOE ε4 status.

scholarly journals The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Patricia Yuste-Checa ◽  
Victoria A. Trinkaus ◽  
Irene Riera-Tur ◽  
Rahmi Imamoglu ◽  
Theresa F. Schaller ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Frontotemporal Dementia ◽  
Brain Regions ◽  
Model System ◽  
Cellular Model ◽  
Tau Pathology ◽  
Extracellular Chaperone ◽  
Tau Aggregate

AbstractSpreading of aggregate pathology across brain regions acts as a driver of disease progression in Tau-related neurodegeneration, including Alzheimer’s disease (AD) and frontotemporal dementia. Aggregate seeds released from affected cells are internalized by naïve cells and induce the prion-like templating of soluble Tau into neurotoxic aggregates. Here we show in a cellular model system and in neurons that Clusterin, an abundant extracellular chaperone, strongly enhances Tau aggregate seeding. Upon interaction with Tau aggregates, Clusterin stabilizes highly potent, soluble seed species. Tau/Clusterin complexes enter recipient cells via endocytosis and compromise the endolysosomal compartment, allowing transfer to the cytosol where they propagate aggregation of endogenous Tau. Thus, upregulation of Clusterin, as observed in AD patients, may enhance Tau seeding and possibly accelerate the spreading of Tau pathology.

scholarly journals Deep Recurrent Model for Individualized Prediction of Alzheimer’s Disease Progression

NeuroImage ◽  
2021 ◽  
pp. 118143
Author(s):  
Wonsik Jung ◽  
Eunji Jun ◽  
Heung-Il Suk ◽  
Alzheimer’s Disease Neuroimaging Initiative
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Individualized Prediction

scholarly journals Discriminating Alzheimer's disease progression using a new hippocampal marker from T1-weighted MRI: The local surface roughness

2018 ◽  
Vol 40 (5) ◽  
pp. 1666-1676 ◽  
Author(s):  
Carlos Platero ◽  
María Eugenia López ◽  
María del Carmen Tobar ◽  
Miguel Yus ◽  
Fernando Maestu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Surface Roughness ◽  
Disease Progression ◽  
Local Surface

Role of inflammatory molecules in the Alzheimer's disease progression and diagnosis

2017 ◽  
Vol 376 ◽  
pp. 242-254 ◽  
Author(s):  
Eva Bagyinszky ◽  
Vo Van Giau ◽  
Kyuhwan Shim ◽  
Kyoungho Suk ◽  
Seong Soo A. An ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Inflammatory Molecules

P1-155: Post-Mortem Brain Tissue Characterisation of Inflammatory and Pathological Hallmarks of Alzheimer’s Disease During Disease Progression

2016 ◽  
Vol 12 ◽  
pp. P462-P462
Author(s):  
Martina M. Hughes ◽  
Beatriz G. Perez-Nievas ◽  
Claire Troakes ◽  
Michael Perkinton ◽  
Diane P. Hanger ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Brain Tissue ◽  
Post Mortem ◽  
Tissue Characterisation ◽  
Post Mortem Brain

P4-238: Total plasma Aβ42/40 ratio is an early biomarker of Alzheimer's disease progression

2015 ◽  
Vol 11 (7S_Part_19) ◽  
pp. P871-P872
Author(s):  
Pedro Pesini ◽  
Virginia Pérez-Grijalba ◽  
Noelia Fandos ◽  
Salvador Olmos ◽  
Matias Bossa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Total Plasma ◽  
Early Biomarker
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