scholarly journals A Bayesian approach for instrumental variable analysis with censored time-to-event outcome

2014 ◽  
Vol 34 (4) ◽  
pp. 664-684 ◽  
Author(s):  
Gang Li ◽  
Xuyang Lu
Keyword(s):  
Bayesian Approach ◽  
Instrumental Variable ◽  
Time To Event ◽  
Instrumental Variable Analysis ◽  
Variable Analysis

Abstract 2323: Statin Use and Discharge Disposition After Ischemic Stroke Hospitalization

Stroke ◽  
2012 ◽  
Vol 43 (suppl_1) ◽  
Author(s):  
Alexander Flint ◽  
Hooman Kamel ◽  
Babak Navi ◽  
Vivek Rao ◽  
Bonnie Faigeles ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Instrumental Variable ◽  
Multivariable Analysis ◽  
Treatment Patterns ◽  
High Dose ◽  
Instrumental Variable Analysis ◽  
Discharge Disposition ◽  
Usual Dose ◽  
Statin Use ◽  
Variable Analysis

Objective: To determine whether statin use is associated with improved discharge disposition after ischemic stroke. Methods: We analyzed 12,689 patients with ischemic stroke over a 7 year period at 17 hospitals in Kaiser Permanente Northern California. We used multivariable generalized ordinal logistic regression and instrumental variable analysis of treatment patterns by hospital to control for the possibility of confounding. Results: Statin users before and during stroke hospitalization were more likely to be discharged home (54.9% for statin users, 46.3% for statin non-users) and less likely to die in hospital (5.3% for statin users, 10.3% for statin non-users). Patients who underwent statin withdrawal in-hospital were less likely to be discharged home (39.1% for statin withdrawal, 54.9% for statin continuation) and more likely to die in hospital (22.3% for statin withdrawal, 5.3% for statin continuation). Users of higher statin doses (>60 mg / day) were even more likely to be discharged home (62.5% for high dose statin, 56.5% for usual dose statin, and 47.4% for no statin) and less likely to die in hospital in-hospital (3.5% for high dose statin, 5.6% for usual dose statin, and 10.6% for no statin). These results were confirmed by multivariable analysis. The association of statin use and improved outcomes was also confirmed by instrumental variable analysis of treatment patterns by hospital, and thus this association cannot be explained by confounding at the individual patient level. Conclusions: Statin use is associated with improved discharge disposition after ischemic stroke, particularly at higher doses.

Methods matter: dealing with low compliance in sports injury trials analyses using instrumental variable analysis

2020 ◽  
pp. bjsports-2020-102155
Author(s):  
Pascal Edouard ◽  
Kathrin Steffen ◽  
Laurent Navarro ◽  
Mohammad Ali Mansournia ◽  
Rasmus Oestergaard Nielsen
Keyword(s):  
Instrumental Variable ◽  
Sports Injury ◽  
Instrumental Variable Analysis ◽  
Variable Analysis
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