scholarly journals Hippocampal shape analysis in Alzheimer's disease using functional data analysis

2013 ◽  
Vol 33 (5) ◽  
pp. 867-880 ◽  
Author(s):  
Irene Epifanio ◽  
Noelia Ventura-Campos
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Data Analysis ◽  
Shape Analysis ◽  
Functional Data Analysis ◽  
Functional Data

Prosodic effects on speech gestures: A shape analysis based on functional data analysis

2013 ◽  
Vol 133 (5) ◽  
pp. 3565-3565
Author(s):  
Christine Mooshammer ◽  
Lasse Bombien ◽  
Jelena Krivokapic
Keyword(s):  
Data Analysis ◽  
Shape Analysis ◽  
Functional Data Analysis ◽  
Functional Data

scholarly journals NUCLEI SHAPE ANALYSIS, A STATISTICAL APPROACH

2011 ◽  
Vol 27 (1) ◽  
pp. 1 ◽  
Author(s):  
Alberto Nettel-Aguirre
Keyword(s):  
Data Analysis ◽  
Shape Analysis ◽  
Functional Data Analysis ◽  
Principal Components ◽  
Functional Data ◽  
Statistical Approach ◽  
Second Derivatives

The method presented in our paper suggests the use of Functional Data Analysis (FDA) techniques in an attempt to characterise the nuclei of two types of cells: Cancer and non-cancer, based on their 2 dimensional profiles. The characteristics of the profile itself, as traced by its X and Y coordinates, their first and second derivatives, their variability and use in characterization are the main focus of this approach which is not constrained to star shaped nuclei. Findings: Principal components created from the coordinates relate to shape with significant differences between nuclei type. Characterisations for each type of profile were found.

scholarly journals Functional data analysis in shape analysis

2011 ◽  
Vol 55 (9) ◽  
pp. 2758-2773 ◽  
Author(s):  
Irene Epifanio ◽  
Noelia Ventura-Campos
Keyword(s):  
Data Analysis ◽  
Shape Analysis ◽  
Functional Data Analysis ◽  
Functional Data

Deformation-based Statistical Shape Analysis of the Corpus Callosum in Mild Cognitive Impairment and Alzheimer’s Disease

2018 ◽  
Vol 15 (12) ◽  
pp. 1151-1160 ◽  
Author(s):  
Zihan Jiang ◽  
Huilin Yang ◽  
Xiaoying Tang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Corpus Callosum ◽  
Shape Analysis ◽  
Disease Assessment ◽  
Statistical Shape Analysis ◽  
Superior Part ◽  
Statistical Shape

Objective: In this study, we investigated the influence that the pathology of Alzheimer’s disease (AD) exerts upon the corpus callosum (CC) using a total of 325 mild cognitive impairment (MCI) subjects, 155 AD subjects, and 185 healthy control (HC) subjects. Method: Regionally-specific morphological CC abnormalities, as induced by AD, were quantified using a large deformation diffeomorphic metric curve mapping based statistical shape analysis pipeline. We also quantified the association between the CC shape phenotype and two cognitive measures; the Mini Mental State Examination (MMSE) and the Alzheimer’s Disease Assessment Scale-Cognitive Behavior Section (ADAS-cog). To identify AD-relevant areas, CC was sub-divided into three subregions; the genu, body, and splenium (gCC, bCC, and sCC). Results: We observed significant shape compressions in AD relative to that in HC, mainly concentrated on the superior part of CC, across all three sub-regions. The HC-vs-MCI shape abnormalities were also concentrated on the superior part, but mainly occurred on bCC and sCC. The significant MCI-vs-AD shape differences, however, were only detected in part of sCC. In the shape-cognition association, significant negative correlations to ADAS-cog were detected for shape deformations at regions belonging to gCC and sCC and significant positive correlations to MMSE at regions mainly belonging to sCC. Conclusion: Our results suggest that the callosal shape deformation patterns, especially those of sCC, linked tightly to the cognitive decline in AD, and are potentially a powerful biomarker for monitoring the progression of AD.

scholarly journals Basis Expansions for Functional Snippets

Biometrika ◽  
2020 ◽  
Author(s):  
Zhenhua Lin ◽  
Jane-Ling Wang ◽  
Qixian Zhong
Keyword(s):  
Data Analysis ◽  
Convergence Rate ◽  
Functional Data Analysis ◽  
Functional Data ◽  
Covariance Function ◽  
Covariance Estimation ◽  
Simulation Studies ◽  
Finite Sample ◽  
Covariance Functions ◽  
The Mean

Summary Estimation of mean and covariance functions is fundamental for functional data analysis. While this topic has been studied extensively in the literature, a key assumption is that there are enough data in the domain of interest to estimate both the mean and covariance functions. In this paper, we investigate mean and covariance estimation for functional snippets in which observations from a subject are available only in an interval of length strictly (and often much) shorter than the length of the whole interval of interest. For such a sampling plan, no data is available for direct estimation of the off-diagonal region of the covariance function. We tackle this challenge via a basis representation of the covariance function. The proposed estimator enjoys a convergence rate that is adaptive to the smoothness of the underlying covariance function, and has superior finite-sample performance in simulation studies.

scholarly journals Novel Analytic Approaches to Investigate Minute-Level Actigraphy and Associations With Physical Function

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 194-195
Author(s):  
Kaiyuan Hua ◽  
Sheng Luo ◽  
Katherine Hall ◽  
Miriam Morey ◽  
Harvey Cohen
Keyword(s):  
Physical Activity ◽  
Data Analysis ◽  
Physical Function ◽  
Functional Data Analysis ◽  
Functional Data ◽  
Gait Speed ◽  
Community Dwelling ◽  
Accelerometer Data ◽  
Single Leg Stance ◽  
Minute Walk

Abstract Background. Functional decline in conjunction with low levels of physical activity has implications for health risks in older adults. Previous studies have examined the associations between accelerometry-derived activity and physical function, but most of these studies reduced these data into average means of total daily physical activity (e.g., daily step counts). A new method of analysis “functional data analysis” provides more in-depth capability using minute-level accelerometer data. Methods. A secondary analysis of community-dwelling adults ages 30 to 90+ residing in southwest region of North Carolina from the Physical Performance across the Lifespan (PALS) study. PALS assessments were completed in-person at baseline and one-week of accelerometry. Final analysis includes 669 observations at baseline with minute-level accelerometer data from 7:00 to 23:00, after removing non-wear time. A novel scalar-on-function regression analysis was used to explore the associations between baseline physical activity features (minute-by-minute vector magnitude generated from accelerometer) and baseline physical function (gait speed, single leg stance, chair stands, and 6-minute walk test) with control for baseline age, sex, race and body mass index. Results. The functional regressions were significant for specific times of day indicating increased physical activity associated with increased physical function around 8:00, 9:30 and 15:30-17:00 for rapid gait speed; 9:00-10:30 and 15:00-16:30 for normal gait speed; 9:00-10:30 for single leg stance; 9:30-11:30 and 15:00-18:00 for chair stands; 9:00-11:30 and 15:00-18:30 for 6-minute walk. Conclusion. This method of functional data analysis provides news insights into the relationship between minute-by-minute daily activity and health.

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