Incorporating historical control data in planning phase II clinical trials

1990 ◽  
Vol 9 (3) ◽  
pp. 215-228 ◽  
Author(s):  
Peter F. Thall ◽  
Richard Simon
Keyword(s):  
Clinical Trials ◽  
Phase Ii ◽  
Historical Control ◽  
Control Data ◽  
Phase Ii Clinical Trials ◽  
Planning Phase ◽  
Historical Control Data

scholarly journals Use of historical control data for assessing treatment effects in clinical trials

2013 ◽  
Vol 13 (1) ◽  
pp. 41-54 ◽  
Author(s):  
Kert Viele ◽  
Scott Berry ◽  
Beat Neuenschwander ◽  
Billy Amzal ◽  
Fang Chen ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Treatment Effects ◽  
Historical Control ◽  
Control Data ◽  
Historical Control Data

scholarly journals Bayesian Approach to Utilize Historical Control Data in Clinical Trials

2015 ◽  
Vol 36 (1) ◽  
pp. 25-50 ◽  
Author(s):  
Kentaro Takeda ◽  
Mari Oba ◽  
Tomoyuki Kakizume ◽  
Kentaro Sakamaki ◽  
Masataka Taguri ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Bayesian Approach ◽  
Historical Control ◽  
Control Data ◽  
Historical Control Data

scholarly journals Incorporating historical control data into the design and analysis of clinical trials

Trials ◽  
2015 ◽  
Vol 16 (S2) ◽  
Author(s):  
Maxine Bennett ◽  
William Powley ◽  
Jeffrey Wetherington ◽  
Adrian Mander
Keyword(s):  
Clinical Trials ◽  
Historical Control ◽  
Control Data ◽  
Historical Control Data

Covariate-adjusted borrowing of historical control data in randomized clinical trials

2017 ◽  
Vol 16 (4) ◽  
pp. 296-308 ◽  
Author(s):  
Baoguang Han ◽  
Jia Zhan ◽  
Z. John Zhong ◽  
Dawei Liu ◽  
Stacy Lindborg
Keyword(s):  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Historical Control ◽  
Control Data ◽  
Historical Control Data

Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity

2020 ◽  
Vol 20 (19) ◽  
pp. 2019-2035
Author(s):  
Esmaeil Sheikh Ahmadi ◽  
Amir Tajbakhsh ◽  
Milad Iranshahy ◽  
Javad Asili ◽  
Nadine Kretschmer ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Biological Activity ◽  
Small Molecules ◽  
Anticancer Activity ◽  
Clinical Significance ◽  
Phase Ii ◽  
Biological Activities ◽  
Phase Ii Clinical Trials ◽  
Naturally Occurring ◽  
The Subject

Naturally occurring naphthoquinones (NQs) comprising highly reactive small molecules are the subject of increasing attention due to their promising biological activities such as antioxidant, antimicrobial, apoptosis-inducing activities, and especially anticancer activity. Lapachol, lapachone, and napabucasin belong to the NQs and are in phase II clinical trials for the treatment of many cancers. This review aims to provide a comprehensive and updated overview on the biological activities of several new NQs isolated from different species of plants reported from January 2013 to January 2020, their potential therapeutic applications and their clinical significance.

Historical control data on developmental toxicity studies in rodents

2014 ◽  
Vol 54 (3) ◽  
pp. 150-161 ◽  
Author(s):  
Makoto Ema ◽  
Katsumi Endoh ◽  
Ryou Fukushima ◽  
Sakiko Fujii ◽  
Hiroaki Hara ◽  
...  
Keyword(s):  
Developmental Toxicity ◽  
Historical Control ◽  
Control Data ◽  
Toxicity Studies ◽  
Historical Control Data
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