A Bayesian order-restricted model for hormonal dynamics during menstrual cycles of healthy women

2011 ◽  
Vol 31 (22) ◽  
pp. 2428-2440 ◽  
Author(s):  
Anindya Roy ◽  
Michelle Danaher ◽  
Sunni L. Mumford ◽  
Zhen Chen
Keyword(s):  
Menstrual Cycles ◽  
Healthy Women ◽  
Restricted Model ◽  
Order Restricted

Assessment of choroidal vascularity index during the menstrual cycle

2021 ◽  
pp. 112067212110576
Author(s):  
Nazife Aşikgarip ◽  
Emine Temel ◽  
Kemal Örnek
Keyword(s):  
Optical Coherence Tomography ◽  
Menstrual Cycle ◽  
Prospective Study ◽  
Luteal Phase ◽  
Choroidal Thickness ◽  
Optical Coherence ◽  
Menstrual Cycles ◽  
Healthy Women ◽  
Luminal Area ◽  
Choroidal Structure

Purpose To explore the effect of menstrual cycle on choroidal vascularity index (CVI). Methods Thirty six eyes of 36 healthy women were included in this prospective study. The menstrual cycles were regular and ranged from 28 to 30 days in length. Optical coherence tomography images were obtained in 3 different phases of the menstrual cycle. The choroidal thickness (CT), total choroidal area, luminal area, stromal area, and CVI were quantified. Results Mean subfoveal, nasal and temporal CT were significantly changed in mid-luteal phase in comparison to early follicular (p = 0.018, p = 0.006 and p = 0.001, respectively) and ovulatory phases (p = 0.037, p = 0.037, and p = 0.035, respectively). Mean CVI showed a significant change in mid-luteal phase when compared with early follicular (p = 0.001) and ovulatory phases (p = 0.036). Conclusion CVI seemed to be affected in mid-luteal phase of menstrual cycle. This should be considered while analyzing choroidal structure in otherwise healthy women.

scholarly journals Salivary Afternoon Cortisol and Relationship Status in Healthy Women With Regular Menstrual Cycles

2018 ◽  
Vol 5 (3) ◽  
pp. 170-182 ◽  
Author(s):  
M. Claire Wilson ◽  
Tierney K. Lorenz ◽  
Julia R. Heiman
Keyword(s):  
Relationship Status ◽  
Menstrual Cycles ◽  
Healthy Women

scholarly journals Influence of female hormonal fluctuation on maximum occlusal force

2011 ◽  
Vol 22 (6) ◽  
pp. 497-501
Author(s):  
Thaís Marques Simek Vega Gonçalves ◽  
Lucíola Maria Rodrigues de Vasconcelos ◽  
Wander José da Silva ◽  
Altair Antoninha Del Bel Cury ◽  
Renata Cunha Matheus Rodrigues Garcia
Keyword(s):  
Menstrual Cycle ◽  
Test Data ◽  
Oral Contraceptives ◽  
Occlusal Force ◽  
Menstrual Cycles ◽  
Healthy Women ◽  
Hormonal Fluctuations ◽  
One Way Anova ◽  
Molar Region ◽  
Hormonal Levels

Hormonal fluctuations during the menstrual cycle may influence on muscular tensions and probably alter occlusal force. The aim of this study was to evaluate whether hormonal levels affect maximum occlusal force (MOF) of healthy women throughout the different phases of the menstrual cycle. Sixty complete dentate subjects who were not under use of oral contraceptives were selected to participate in this study. MOF was bilaterally evaluated on the molar region, during 3 complete menstrual cycles, using 5.65 mm-wide sensors. Measurements were carried out during each of the following menstrual cycle phases: menstrual, follicular, periovulatory and luteal, presumed by ovulation test. Data were analyzed by one-way ANOVA and Tukey-Kramer test (p<0.05). Comparisons among menstrual cycle phases showed no differences on MOF (p=0.27). Under the conditions of this study, it may be concluded that hormonal fluctuations during the menstrual cycle do not affect MOF of a sample of healthy women.

scholarly journals Menopause Transition: Annual Changes in Serum Hormonal Patterns over the Menstrual Cycle in Women during a Nine-Year Period Prior to Menopause

2004 ◽  
Vol 89 (6) ◽  
pp. 2763-2769 ◽  
Author(s):  
Britt-Marie Landgren ◽  
Aila Collins ◽  
Giorgy Csemiczky ◽  
Henry G. Burger ◽  
Lyrissa Baksheev ◽  
...  
Keyword(s):  
Follicular Phase ◽  
Serum Progesterone ◽  
Menstrual Cycles ◽  
Prolonged Length ◽  
Healthy Women ◽  
Early Follicular Phase ◽  
Serum Hormone ◽  
Menopause Transition ◽  
Collection Period ◽  
Number Of Cycles

Abstract To examine the hormonal characteristics of menstrual cycles in healthy women approaching menopause, serum hormone profiles were investigated annually in this longitudinal study of 13 healthy women between 4 and 9 yr before menopause and the year of the menopause. Serum FSH, LH, estradiol, progesterone, total inhibin, inhibins A and B, and prolactin were determined in blood samples collected annually three times weekly for 4 wk beginning with the onset of menses. Menstrual bleeding diaries covering this 4- to 9-yr period were also collected allowing the prospective identification of the final menstrual period. A change in serum hormone patterns was observed in cycles approaching menopause, exemplified by an increasing number of cycles of prolonged length with a prolonged follicular phase resulting in a failure to detect a luteal phase rise in serum progesterone within the 4-wk collection period. These prolonged cycles (designated B cycles based on a previous work) were analyzed separately and compared with the remaining ovulatory (D) cycles. No B cycles were identified in any women earlier than 27 cycles from menopause. The proportion of B cycles increased as menopause approached, reaching 62% in the last 10 cycles. The proportion of D cycles decreased accordingly. The B cycles during the initial 4-wk collection period were characterized by elevated FSH, LH, FSH/inhibin A and FSH/inhibin B ratios, and longer duration, although cycle length/subject was not significantly different presumably due to the small number of B cycles. The D cycles showed no changes in hormonal profiles over the 4- to 9-yr time period. These data indicate that there is a time-related change in the character of menstrual cycles as menopause approaches, with an increasing proportion of cycles observed with prolonged follicular phases that may either be delayed ovulatory cycles or anovulatory cycles. The increase in the proportion of B cycles with elevated early follicular phase FSH levels and low inhibin/FSH ratios toward menopause provides a basis for the apparent early increase in serum FSH and decrease in serum inhibins observed previously in studies of the menopause transition based on sampling confined to the follicular phase only. The data amplify and clarify current concepts of the endocrine basis of the menopause transition.

Physiological changes of adipokines during the menstrual cycle

2016 ◽  
Vol 62 (5) ◽  
pp. 41-42
Author(s):  
Monika Šrámková ◽  
Michaela Dušková ◽  
Jana Vítků ◽  
Petr Matucha ◽  
Olga Bradnová ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Magnetic Bead ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormonal Contraceptives ◽  
Physiological Changes ◽  
Menstrual Cycles ◽  
Healthy Women ◽  
Notable Increase ◽  
17 Hydroxyprogesterone

Background. The cyclical effects of hormones during the menstrual cycle (MC) are responsible for driving ovulation. The information about roles of adipokines within the scope of MC are not definite. Leptin plays a role in sexual function and regulating the onset of puberty. Thin girls often fail to ovulate or release an egg from an ovary during menstruation cycles. Leptin also acts on specific receptors in the hypothalamus to inhibit appetite. Levels of leptin are increased in women suffering from premenstrual syndrome.Aim. The aim of our study was to describe physiological changes of selected steroids and adipokines at healthy women during the MC.Methods. Twenty-seven women with regular menstrual cycles were included in the study. Each sample was collected in cooled EDTA tubes, centrifuged at 2000 rpm in a refrigerated centrifuge, and stored at –80 °C. For all samples we measured luteinizing hormone (LH), follicularstimulating hormone (FSH), sex hormone-binding globulin (SHBG), testosterone, dehydroepiandrosterone (DHEA), estradiol, 7α-DHEA, 7β-DHEA, 7-oxoDHEA, 17-hydroxyprogesterone (17-OH P), progesterone, cortisol, adrenocorticotropic hormone (ACTH) by RIA and IRMA. Levels in plasma of hormones associated with food intake (c-peptide, ghreline, GIP, GLP, GLP-1, glucagon, insulin, leptin, PAI-1, resistin and visfatin) were measured using magnetic bead-based multiple assays (x-MAP technology, Luminex Corporation). Two kits were used: the 10-plex Bio-Plex Pro Human Diabetes assay and the 2-plex Bio-Plex Pro Human Adiponectin and Adipsin assay (both Bio-Rad Laboratories).Patient. Twenty-seven women with regular menstrual cycles (cycle length 28±2 days) were included in the study. The average age of the women was 31.8±3.56, and average BMI 22.9±2.8. The women used no hormonal contraceptives or other medicines influencing the production of steroid hormones, and were non-smokers. Before enrollment in the study, all signed informed consent that was approved by the local ethical committee of the Institute of Endocrinology.Intervention. Fasting blood samples were taken in the morning between 7 and 8 am. The first sampling was done at the start of the menstrual cycle (1st or 2nd day). Subsequent samples were taken at regular intervals every three days, for a total of 10 samples taken during the study.Main outcome measures. During the MC we found increased levels of testosterone, estradiol, progesterone, and 17-hydroxyprogesterone during ovulation. SHBG gradually increased after ovulation. There was a significant decrease in resistin levels during ovulation, followed by an increase in the latter part of the cycle. Adipsin showed a notable increase during ovulation, but this increase was not statistically significant.Results. Classical changes in gonadotropins, estrogens and progesterone during the menstrual cycle are accompanied by less striking but significant changes in 17-hydroxyprogesterone and testosterone. No significant changes show dehydroepiandrosterone and its 7-oxygenated metabolites. Adipokines show a tendency to increase during ovulation, while ghrelin and resistin decrease. There is also a remarkable association of sex hormone binging globuline (SHBG) on the day of the cycle.Conclusions. Our results demonstrate that changes to adipokines during the menstrual cycle are not substantial. Differing leptin levels are characteristic for premenstrual syndrome. Precise descriptions of physiological changes in healthy women are important in helping us understand the significance of the changes accompanying various pathological states.

Changes in plasma volume during bed rest: effects of menstrual cycle and estrogen administration

1988 ◽  
Vol 65 (2) ◽  
pp. 525-533 ◽  
Author(s):  
S. M. Fortney ◽  
W. S. Beckett ◽  
A. J. Carpenter ◽  
J. Davis ◽  
H. Drew ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Plasma Volume ◽  
Bed Rest ◽  
Transient Effects ◽  
Menstrual Cycles ◽  
Healthy Women ◽  
Exogenous Estrogen ◽  
Estrogen Administration ◽  
Estrogen Concentration

Bed rest (BR) is associated with a decrease in plasma volume (PV), which may contribute to the impaired orthostatic and exercise tolerances seen immediately after BR. The purpose of this study was to determine whether increases in blood estrogen concentration, either during normal menstrual cycles or during exogenous estrogen administration, would attenuate this loss of PV. Nineteen healthy women (21-39 yr of age) completed the study. Twelve women underwent duplicate 11-day BR without estrogen supplementation. PV decreased significantly (P less than or equal to 0.01) during both BR's, from 2,531 +/- 113 to 2,027 +/- 102 ml during BR1 and from 2,445 +/- 115 to 2,244 +/- 96 ml during BR2. The women who began BR in the periovulatory stage of the menstrual cycle (n = 3), a time of elevated endogenous estrogens, had a transient delay in loss of PV during the first 5 days of BR. Women who began BR during other stages of the menstrual cycle (n = 17) showed the established trend to decrease PV primarily during the first few days of BR. Seven additional women underwent a single 12-day BR while taking estrogen supplementation (1.25 mg/day premarin). PV decreased during the first 4-5 days of BR, then returned toward the pre-BR level during the remainder of the BR (pre-BR PV, 2,525 +/- 149 ml; post-BR PV, 2,519 +/- 162 ml). Thus menstrual fluctuations in endogenous estrogens appear to have only small transient effects on the loss of PV during BR, whereas exogenous estrogen supplementation significantly attenuates PV loss.

Serotonin Concentrations in Plasma and Variations During the Menstrual Cycle

1992 ◽  
Vol 38 (10) ◽  
pp. 2087-2089 ◽  
Author(s):  
I Hindberg ◽  
O Naesh
Keyword(s):  
Menstrual Cycle ◽  
Healthy Volunteers ◽  
Plasma Concentrations ◽  
Reference Interval ◽  
Serotonin Concentration ◽  
Very Old ◽  
Menstrual Cycles ◽  
Platelet Poor Plasma ◽  
Healthy Women

Abstract We used a specific and sensitive radioenzymatic method to establish a reference interval for the concentration of serotonin in platelet-poor plasma in 98 healthy volunteers (49 men, 49 women). The interval was 0-11 nmol/L with a median of 2.8 nmol/L. No difference in concentration in relation to sex or age was observed. In a group of eight very old volunteers (ages 86-92 years), however, concentrations were increased. In addition, we monitored the plasma concentrations of serotonin in 20 healthy women (ages 26-45 years) through two menstrual cycles. Periovulatory and premenstrual concentrations were greater than the serotonin concentration at the start of menstruation.

Diurnal and menstrual cycles in body temperature are regulated differently: A 28-day ambulatory study in healthy women with thermal discomfort of cold extremities and controls

2013 ◽  
Vol 31 (1) ◽  
pp. 102-113 ◽  
Author(s):  
Kurt Kräuchi ◽  
Katarzyna Konieczka ◽  
Corina Roescheisen-Weich ◽  
Britta Gompper ◽  
Daniela Hauenstein ◽  
...  
Keyword(s):  
Body Temperature ◽  
Thermal Discomfort ◽  
Menstrual Cycles ◽  
Healthy Women ◽  
Cold Extremities

Temporal stability of conditioned pain modulation in healthy women over four menstrual cycles at the follicular and luteal phases

Pain ◽  
2013 ◽  
Vol 154 (12) ◽  
pp. 2633-2638 ◽  
Author(s):  
Hilary Wilson ◽  
Brendan Carvalho ◽  
Michal Granot ◽  
Ruth Landau
Keyword(s):  
Temporal Stability ◽  
Pain Modulation ◽  
Conditioned Pain Modulation ◽  
Menstrual Cycles ◽  
Healthy Women
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