Genetic analysis of age-at-onset traits based on case-control family data

2010 ◽  
Vol 29 (30) ◽  
pp. 3258-3266 ◽  
Author(s):  
Benjamin H. Yip ◽  
Tron Anders Moger ◽  
Yudi Pawitan
Keyword(s):  
Genetic Analysis ◽  
Age At Onset ◽  
Case Control ◽  
Family Data ◽  
Control Family

Incorporation of the time aspect into the liability-threshold model for case-control-family data

2017 ◽  
Author(s):  
Luise Cederkvist ◽  
Klaus K. Holst ◽  
Klaus K. Andersen ◽  
David V. Glidden ◽  
Kirsten Frederiksen ◽  
...  
Keyword(s):  
Threshold Model ◽  
Case Control ◽  
Family Data ◽  
Control Family

Family-Specific Approaches to the Analysis of Case-Control Family Data

Biometrics ◽  
2005 ◽  
Vol 62 (2) ◽  
pp. 488-494 ◽  
Author(s):  
J. M. Neuhaus ◽  
A. J. Scott ◽  
C. J. Wild
Keyword(s):  
Case Control ◽  
Family Data ◽  
Control Family

scholarly journals Missing genetic information in case-control family data with general semi-parametric shared frailty model

2010 ◽  
Vol 17 (2) ◽  
pp. 175-194 ◽  
Author(s):  
Anna Graber-Naidich ◽  
Malka Gorfine ◽  
Kathleen E. Malone ◽  
Li Hsu
Keyword(s):  
Genetic Information ◽  
Frailty Model ◽  
Case Control ◽  
Family Data ◽  
Shared Frailty Model ◽  
Shared Frailty ◽  
Control Family

scholarly journals Population-Based Estimates of the Age-Specific Cumulative Risk of Breast Cancer for Pathogenic Variants in CHEK2: Findings from the Australian Breast Cancer Family Registry

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1378
Author(s):  
Tú Nguyen-Dumont ◽  
James G. Dowty ◽  
Jason A. Steen ◽  
Anne-Laure Renault ◽  
Fleur Hammet ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cumulative Risk ◽  
Population Based ◽  
Case Control ◽  
Cancer Information ◽  
Case Control Studies ◽  
Breast Cancer Family ◽  
Pathogenic Variants ◽  
Increased Risk ◽  
Control Family

Case-control studies of breast cancer have consistently shown that pathogenic variants in CHEK2 are associated with about a 3-fold increased risk of breast cancer. Information about the recurrent protein-truncating variant CHEK2 c.1100delC dominates this estimate. There have been no formal estimates of age-specific cumulative risk of breast cancer for all CHEK2 pathogenic (including likely pathogenic) variants combined. We conducted a population-based case-control-family study of pathogenic CHEK2 variants (26 families, 1071 relatives) and estimated the age-specific cumulative risk of breast cancer using segregation analysis. The estimated hazard ratio for carriers of pathogenic CHEK2 variants (combined) was 4.9 (95% CI 2.5–9.5) relative to non-carriers. The HR for carriers of the CHEK2 c.1100delC variant was estimated to be 3.5 (95% CI 1.02–11.6) and the HR for carriers of all other CHEK2 variants combined was estimated to be 5.7 (95% CI 2.5–12.9). The age-specific cumulative risk of breast cancer was estimated to be 18% (95% CI 11–30%) and 33% (95% CI 21–48%) to age 60 and 80 years, respectively. These findings provide important information for the clinical management of breast cancer risk for women carrying pathogenic variants in CHEK2.

Analysis of Age of Onset Data from Case-Control Family Studies

Biometrics ◽  
1998 ◽  
Vol 54 (3) ◽  
pp. 1030 ◽  
Author(s):  
Hongzhe Li ◽  
Ping Yang ◽  
Ann G. Schwartz
Keyword(s):  
Age Of Onset ◽  
Family Studies ◽  
Case Control ◽  
Control Family
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