scholarly journals Using short-term response information to facilitate adaptive randomization for survival clinical trials

2009 ◽  
Vol 28 (12) ◽  
pp. 1680-1689 ◽  
Author(s):  
Xuelin Huang ◽  
Jing Ning ◽  
Yisheng Li ◽  
Elihu Estey ◽  
Jean-Pierre Issa ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Short Term ◽  
Adaptive Randomization ◽  
Response Information ◽  
Term Response

scholarly journals Spontaneous improvement of carbohydrate-deficient transferrin in PMM2-CDG without mannose observed in CDG natural history study

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Peter Witters ◽  
Andrew C. Edmondson ◽  
Christina Lam ◽  
Christin Johnsen ◽  
Marc C. Patterson ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Natural History ◽  
Randomized Study ◽  
Short Term ◽  
Double Blind ◽  
Natural History Study ◽  
Natural History Studies ◽  
Carbohydrate Deficient Transferrin ◽  
Spontaneous Improvement

AbstractA recent report on long-term dietary mannose supplementation in phosphomannomutase 2 deficiency (PMM2-CDG) claimed improved glycosylation and called for double-blind randomized study of the dietary supplement in PMM2-CDG patients. A lack of efficacy of short-term mannose supplementation in multiple prior reports challenge this study’s conclusions. Additionally, some CDG types have previously been reported to demonstrate spontaneous improvement in glycosylated biomarkers, including transferrin. We have likewise observed improvements in transferrin glycosylation without mannose supplementation. This observation questions the reliability of transferrin as a therapeutic outcome measure in clinical trials for PMM2-CDG. We are concerned that renewed focus on mannose therapy in PMM2-CDG will detract from clinical trials of more promising therapies. Approaches to increase efficiency of clinical trials and ultimately improve patients’ lives requires prospective natural history studies and identification of reliable biomarkers linked to clinical outcomes in CDG. Collaborations with patients and families are essential to identifying meaningful study outcomes.

Unfolding the case of returnees: How the European Union and its member States are addressing the return of foreign fighters and their families

2021 ◽  
pp. 1-23
Author(s):  
Carlota Rigotti ◽  
Júlia Zomignani Barboza
Keyword(s):  
European Union ◽  
Perceived Threat ◽  
The European Union ◽  
Security Threat ◽  
Short Term ◽  
Member States ◽  
Foreign Fighters ◽  
Term Response

Abstract The return of foreign fighters and their families to the European Union has mostly been considered a security threat by member States, which consequently adopt repressive measures aimed at providing an immediate, short-term response to this perceived threat. In addition to this strong-arm approach, reintegration strategies have also been used to prevent returnees from falling back into terrorism and to break down barriers of hostility between citizens in the long term. Amidst these different strategies, this paper seeks to identify which methods are most desirable for handling returnees.

Short-term response of CO2 emissions to various leaf litters: a case study from freshwater marshes of Northeast China

2016 ◽  
Vol 25 (1) ◽  
pp. 119-128
Author(s):  
Chao Gong ◽  
Changchun Song ◽  
Xinhou Zhang ◽  
Wenwen Tan ◽  
Tianhua Qiao
Keyword(s):  
Co2 Emissions ◽  
Northeast China ◽  
Short Term ◽  
Freshwater Marshes ◽  
Term Response

Short-term response of soil microorganisms to biochar addition in a temperate agroecosystem under soil warming

2016 ◽  
Vol 233 ◽  
pp. 308-317 ◽  
Author(s):  
Chris Bamminger ◽  
Christian Poll ◽  
Christina Sixt ◽  
Petra Högy ◽  
Dominik Wüst ◽  
...  
Keyword(s):  
Soil Microorganisms ◽  
Soil Warming ◽  
Short Term ◽  
Term Response
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