scholarly journals Ventricular remodeling in ischemic heart failure stratifies responders to stem cell therapy

2019 ◽  
Vol 9 (1) ◽  
pp. 74-79 ◽  
Author(s):  
Satsuki Yamada ◽  
D. Kent Arrell ◽  
Christian S. Rosenow ◽  
Jozef Bartunek ◽  
Atta Behfar ◽  
...  
Keyword(s):  
Heart Failure ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Ventricular Remodeling ◽  
Ischemic Heart ◽  
Ischemic Heart Failure

scholarly journals SAFEty and efficacy of autologous bone marrow – derived mononuclear stem cell therapy in patients with severe chronic ischemic Heart Failure – rationale and design

2020 ◽  
Vol 25 (6) ◽  
pp. 2118-2126
Author(s):  
MIRUNA M. MICHEU ◽  
◽  
NICOLETA M. POPA-FOTEA ◽  
VLAD BATAILA ◽  
NICOLETA OPRESCU ◽  
...  
Keyword(s):  
Heart Failure ◽  
Bone Marrow ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Autologous Bone Marrow ◽  
Ischemic Heart Failure ◽  
Safety And Efficacy ◽  
Chronic Ischemic Heart Failure ◽  
Autologous Bone

The main aim of this study is to explore the safety and efficacy of autologous bone marrow – derived mononuclear stem cell therapy in patients with severe chronic ischemic heart failure on short to medium-term (1-3 months). The SAFE-HF trial is a prospective, single center, two-arm, controlled trial with blind evaluation of endpoints. Target population will consist of patients with heart failure due to prior extensive myocardial infarction and left ventricle ejection fraction of less than 35% – namely the population with the highest risk of adverse events and the highest mortality. All patients will be treated with the state of the art reperfusion – primary percutaneous coronary intervention and also with guidelinebased optimal medical therapy. The stem cell injection will be performed 1 to 3 months after the acute event; evolution of stem cell treated patients will be compared with matched control–cases. Comprehensive assessment of outcomes will be done at 1 and 3 months follow-up; serum biomarkers, cardiac structural and physiological parameters, functional capacity and health-related quality of life will be evaluated. This pilot study possibly will serve as a foundation for designing future trials.

scholarly journals Stem Cell Therapy in Acute Coronary Syndrome

2006 ◽  
Vol 4 (1) ◽  
pp. 9-12
Author(s):  
Rajib Rajbhandari
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Acute Coronary Syndrome ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cardiovascular Medicine ◽  
Coronary Syndrome

Acule coronary syndrome and congestive heart failure are still among challenging problems in the field of cardiovascular medicine despite many advances in the field. Stem cell therapy has come as a new hope and a promise for the hopeless.

Stem cell therapy in heart failure: Is the best yet to come?

2018 ◽  
Vol 260 ◽  
pp. 135-136 ◽  
Author(s):  
Sarah Costantino ◽  
Francesco Paneni
Keyword(s):  
Heart Failure ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
To Come
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