Effects of probe pollutants on morphological and mechanical measurements of muscle and collagen fibers using atomic force microscopy

Scanning ◽  
2010 ◽  
Vol 32 (3) ◽  
pp. 113-121 ◽  
Author(s):  
Jie Zhu ◽  
Tanya Sabharwal ◽  
Lianhong Guo ◽  
Jenny Lee ◽  
Lin Wang ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Collagen Fibers ◽  
Force Microscopy ◽  
Atomic Force ◽  
Mechanical Measurements

Atomic Force Microscopy Study of Atherosclerosis Progression in Arterial Walls

2016 ◽  
Vol 22 (2) ◽  
pp. 311-325 ◽  
Author(s):  
Peter S. Timashev ◽  
Svetlana L. Kotova ◽  
Galina V. Belkova ◽  
Ekaterina V. Gubar’kova ◽  
Lidia B. Timofeeva ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Cross Sections ◽  
Microscopy Study ◽  
Collagen Fibers ◽  
Lipid Core ◽  
Force Microscopy ◽  
Atherosclerosis Progression ◽  
Plaque Type ◽  
Atomic Force ◽  
Thickened Intima

AbstractCardiovascular disease remains the leading cause of mortality worldwide. Here we suggest a novel approach for tracking atherosclerosis progression based on the use of atomic force microscopy (AFM). Using AFM, we studied cross-sections of coronary arteries with the following types of lesions: Type II—thickened intima; Type III—thickened intima with a lipid streak; Type IV—fibrotic layer over a lipid core; Type Va—unstable fibrotic layer over a lipid core; Type Vc—very thick fibrotic layer. AFM imaging revealed that the fibrotic layer of an atherosclerotic plaque is represented by a basket-weave network of collagen fibers and a subscale network of fibrils that become looser with atherosclerosis progression. In an unstable plaque (Type Va), packing of the collagen fibers and fibrils becomes even less uniform than that at the previous stages, while a stable fibrotic plaque (Vc) has significantly tighter packing. Such alterations of the collagen network morphology apparently, led to deterioration of the Type Va plaque mechanical properties, that, in turn, resulted in its instability and propensity to rupture. Thus, AFM may serve as a useful tool for tracking atherosclerosis progression in the arterial wall tissue.

scholarly journals Comparison of cell mechanical measurements provided by Atomic Force Microscopy (AFM) and Micropipette Aspiration (MPA)

2019 ◽  
Vol 95 ◽  
pp. 103-115 ◽  
Author(s):  
Rafael Daza ◽  
Blanca González-Bermúdez ◽  
Julia Cruces ◽  
Mónica De la Fuente ◽  
Gustavo R. Plaza ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Micropipette Aspiration ◽  
Force Microscopy ◽  
Atomic Force ◽  
Mechanical Measurements

scholarly journals Space-resolved quantitative mechanical measurements of soft and supersoft materials by atomic force microscopy

2016 ◽  
Vol 8 (11) ◽  
pp. e327-e327 ◽  
Author(s):  
Massimiliano Galluzzi ◽  
Chandra S Biswas ◽  
Yuhang Wu ◽  
Qiao Wang ◽  
Bing Du ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Force Microscopy ◽  
Atomic Force ◽  
Mechanical Measurements

Mechanical measurements of ultra-thin amorphous carbon membranes using scanning atomic force microscopy

Carbon ◽  
2012 ◽  
Vol 50 (6) ◽  
pp. 2220-2225 ◽  
Author(s):  
Ji Won Suk ◽  
Shanthi Murali ◽  
Jinho An ◽  
Rodney S. Ruoff
Keyword(s):  
Atomic Force Microscopy ◽  
Amorphous Carbon ◽  
Force Microscopy ◽  
Carbon Membranes ◽  
Atomic Force ◽  
Mechanical Measurements
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