scholarly journals Acute infection as a trigger for incident venous thromboembolism: Results from a population-based case-crossover study

2017 ◽  
Vol 2 (1) ◽  
pp. 85-92 ◽  
Author(s):  
Gro Grimnes ◽  
Trond Isaksen ◽  
Y. I. G. Vladimir Tichelaar ◽  
Sigrid K. Braekkan ◽  
John-Bjarne Hansen
Keyword(s):  
Venous Thromboembolism ◽  
Crossover Study ◽  
Acute Infection ◽  
Population Based ◽  
Case Crossover

scholarly journals The Role of Stroke as a Trigger for Incident Venous Thromboembolism: Results from a Population-based Case-Crossover Study

TH Open ◽  
2019 ◽  
Vol 03 (01) ◽  
pp. e50-e57
Author(s):  
Vânia Morelli ◽  
Joakim Sejrup ◽  
Birgit Småbrekke ◽  
Ludvig Rinde ◽  
Gro Grimnes ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Acute Stroke ◽  
Crossover Study ◽  
Conditional Logistic Regression ◽  
Population Based ◽  
Red Blood Cell Transfusion ◽  
Odds Ratios ◽  
Case Crossover ◽  
Increased Risk

AbstractStroke is associated with a short-term increased risk of subsequent venous thromboembolism (VTE). It is unclear to what extent this association is mediated by stroke-related complications that are potential triggers for VTE, such as immobilization and infection. We aimed to investigate the role of acute stroke as a trigger for incident VTE while taking other concomitant VTE triggers into account. We conducted a population-based case-crossover study with 707 VTE patients. Triggers were registered during the 90 days before a VTE event (hazard period) and in four preceding 90-day control periods. Conditional logistic regression was used to estimate odds ratios with 95% confidence intervals (CIs) for VTE according to triggers. Stroke was registered in 30 of the 707 (4.2%) hazard periods and in 6 of the 2,828 (0.2%) control periods, resulting in a high risk of VTE, with odds ratios of 20.0 (95% CI: 8.3–48.1). After adjustments for immobilization and infection, odds ratios for VTE conferred by stroke were attenuated to 6.0 (95% CI: 1.6–22.1), and further to 4.0 (95% CI: 1.1–14.2) when other triggers (major surgery, red blood cell transfusion, trauma, and central venous catheter) were added to the regression model. A mediation analysis revealed that 67.8% of the total effect of stroke on VTE risk could be mediated through immobilization and infection. Analyses restricted to ischemic stroke yielded similar results. In conclusion, acute stroke was a trigger for VTE, and the association between stroke and VTE risk appeared to be largely mediated by immobilization and infection.

scholarly journals C-reactive protein and risk of venous thromboembolism: results from a population-based case-crossover study

Haematologica ◽  
2018 ◽  
Vol 103 (7) ◽  
pp. 1245-1250 ◽  
Author(s):  
Gro Grimnes ◽  
Trond Isaksen ◽  
Ynse Ieuwe Gerardus Vladimir Tichelaar ◽  
Jan Brox ◽  
Sigrid Kufaas Brækkan ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Crossover Study ◽  
Population Based ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Case Crossover

scholarly journals Hospitalization as a trigger for venous thromboembolism – Results from a population-based case-crossover study

2019 ◽  
Vol 176 ◽  
pp. 115-119 ◽  
Author(s):  
Esben Bjøri ◽  
Håkon S. Johnsen ◽  
John-Bjarne Hansen ◽  
Sigrid K. Brækkan
Keyword(s):  
Venous Thromboembolism ◽  
Crossover Study ◽  
Population Based ◽  
Case Crossover

scholarly journals Alcohol and risk of admission to hospital for unintentional cutting or piercing injuries at home: a population-based case-crossover study

2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Simon Thornley ◽  
Bridget Kool ◽  
Elizabeth Robinson ◽  
Roger Marshall ◽  
Gordon S Smith ◽  
...  
Keyword(s):  
Crossover Study ◽  
Population Based ◽  
Case Crossover ◽  
At Home

Proton pump inhibitor-related headaches: A nationwide population-based case-crossover study in Taiwan

Cephalalgia ◽  
2014 ◽  
Vol 35 (3) ◽  
pp. 203-210 ◽  
Author(s):  
Jen-Feng Liang ◽  
Yung-Tai Chen ◽  
Jong-Ling Fuh ◽  
Szu-Yuan Li ◽  
Tzeng-Ji Chen ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Crossover Study ◽  
Proton Pump ◽  
Conditional Logistic Regression ◽  
Population Based ◽  
Female Patients ◽  
Case Crossover ◽  
Increased Risk ◽  
Tension Type Headaches ◽  
Acute Headache

Background Headaches resulting from proton pump inhibitor (PPI) use could cause discontinuation of PPI in as many as 40% of patients who experience such headaches. Previous studies focusing on acute headache risk from PPI use are rare and limited to clinical trials of a single PPI. Objectives To investigate the association between PPI use and headache with a nationwide population-based case-crossover study. Methods Records containing the first diagnosis of any headache, including migraine and tension-type headaches, were retrieved from Taiwan National Health Insurance Database (1998–2010). We compared the rates of PPI use for cases and controls during time windows of 7, 14, and 28 days. The adjusted self-matched odds ratios (ORs) and 95% confidence intervals (CIs) from a conditional logistic regression model were used to determine the association between PPI use and headache. Results Overall, 314,210 patients with an initial diagnosis of any headache during the study period were enrolled. The adjusted ORs for headache risk after PPI exposure were calculated for three time periods (within 7 days = 1.41, p = 0.002, 95% CI 1.14–1.74; within 14 days = 1.36, p < 0.001, 95% CI 1.16–1.59; within 28 days = 1.20, p = 0.002, 95% CI 1.07–1.35). Subgroup analyses showed female patients had an increased risk of headache. Among PPIs, lansoprazole and esomeprazole had the highest risks of headache incidence, which were similar to that of nitrates. Conclusion PPI usage is associated with an increased risk for acute headache. Female patients and use of lansoprazole or esomeprazole present the greatest risks of headache.

Short-term use of glucocorticoids and risk of peptic ulcer bleeding: a nationwide population-based case-crossover study

2015 ◽  
Vol 42 (5) ◽  
pp. 599-606 ◽  
Author(s):  
C.-L. Tseng ◽  
Y.-T. Chen ◽  
C.-J. Huang ◽  
J.-C. Luo ◽  
Y.-L. Peng ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Crossover Study ◽  
Population Based ◽  
Ulcer Bleeding ◽  
Peptic Ulcer Bleeding ◽  
Short Term ◽  
Case Crossover
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