scholarly journals Automatic synthesis of feedforward elements in quantitative feedback theory

2021 ◽  
Author(s):  
Jorge Elso ◽  
J. Xabier Ostolaza
Keyword(s):  
Quantitative Feedback Theory ◽  
Automatic Synthesis

Automatic synthesis of optimal invariant assertions

1977 ◽  
Vol 12 (8) ◽  
pp. 1-12 ◽  
Author(s):  
Patrick Cousot ◽  
Radhia Cousot
Keyword(s):  
Automatic Synthesis

scholarly journals Standardization of the [68Ga]Ga-PSMA-11 Radiolabeling Protocol in an Automatic Synthesis Module: Assessments for PET Imaging of Prostate Cancer

2021 ◽  
Vol 14 (5) ◽  
pp. 385
Author(s):  
Leonardo L. Fuscaldi ◽  
Danielle V. Sobral ◽  
Ana Claudia R. Durante ◽  
Fernanda F. Mendonça ◽  
Ana Cláudia C. Miranda ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Pet Imaging ◽  
Saline Solution ◽  
Serum Proteins ◽  
Single Photon ◽  
Imaging Techniques ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Lncap Cells ◽  
Automatic Synthesis

Prostate-specific membrane antigen (PSMA) is a glycoprotein present in the prostate, that is overexpressed in prostate cancer (PCa). Recently, PSMA-directed radiopharmaceuticals have been developed, allowing the pinpointing of tumors with the Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging techniques. The aim of the present work was to standardize and validate an automatic synthesis module-based radiolabeling protocol for [68Ga]Ga-PSMA-11, as well as to produce a radiopharmaceutical for PET imaging of PCa malignancies. [68Ga]Ga-PSMA-11 was evaluated to determine the radiochemical purity (RCP), stability in saline solution and serum, lipophilicity, affinity to serum proteins, binding and internalization to lymph node carcinoma of the prostate (LNCaP) cells, and ex vivo biodistribution in mice. The radiopharmaceutical was produced with an RCP of 99.06 ± 0.10%, which was assessed with reversed-phase high-performance liquid chromatography (RP-HPLC). The product was stable in saline solution for up to 4 h (RCP > 98%) and in serum for up to 1 h (RCP > 95%). The lipophilicity was determined as −3.80 ± 0.15, while the serum protein binding (SPB) was <17%. The percentages of binding to LNCaP cells were 4.07 ± 0.51% (30 min) and 4.56 ± 0.46% (60 min), while 19.22 ± 2.73% (30 min) and 16.85 ± 1.34% (60 min) of bound material was internalized. High accumulation of [68Ga]Ga-PSMA-11 was observed in the kidneys, spleen, and tumor, with a tumor-to-contralateral-muscle ratio of >8.5 and a tumor-to-blood ratio of >3.5. In conclusion, an automatic synthesis module-based radiolabeling protocol for [68Ga]Ga-PSMA-11 was standardized and the product was evaluated, thus verifying its characteristics for PET imaging of PCa tumors in a clinical environment.

Suppression of heavy-truck driver-seat vibration using sliding-mode control and quantitative feedback theory

2007 ◽  
Vol 221 (5) ◽  
pp. 769-779
Author(s):  
N. I. Rajapakse ◽  
G. S. Happawana ◽  
Y Hurmuzlu
Keyword(s):  
Sliding Mode Control ◽  
Control Method ◽  
Sliding Mode ◽  
Optimization Methods ◽  
Heavy Vehicle ◽  
Quantitative Feedback Theory ◽  
Mode Control ◽  
Smooth Tracking ◽  
Noise Amplification ◽  
Seat Vibration

The current paper presents a robust control method that combines sliding-mode control (SMC) and quantitative feedback theory (QFT) for designing a driver seat of a heavy vehicle to reduce driver fatigue. A mathematical model is considered to analyse tracking control characteristics through computer simulation in order to demonstrate the effectiveness of the proposed control methodology. The SMC is used to track the trajectory of the desired motion behaviour of the seat. However, when the system enters into sliding regime, chattering occurs owing to switching delays as well as vehicle system vibrations. The chattering is eliminated with the introduction QFT inside the boundary layer to ensure smooth tracking. Furthermore, using SMC alone requires higher actuator forces for tracking than using both the control schemes together, and causes various problems in selecting hardware. Problems with noise amplification, resonances, presence of uncertainties, and unmodelled high-frequency dynamics can largely be avoided with the use of QFT over other optimization methods. The main contribution of the present paper is to provide guidance in designing the controller to reduce heavy vehicle seat vibration so that the driver's sensation of comfort maintains a certain level at all times.

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