scholarly journals The relationship of 4‐vinylcyclohexene diepoxide toxicity with cell death, oxidative stress, and gap junctions in female rat ovaries

2021 ◽  
Author(s):  
Busra SEN HALICIOGLU ◽  
Khandakar A. S. M. SAADAT ◽  
Mehmet Ibrahim TUGLU
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Gap Junctions ◽  
Female Rat ◽  
Vinylcyclohexene Diepoxide ◽  
Relationship Of ◽  
The Relationship

scholarly journals Adipokines: mechanisms of metabolic and behavioral disorders

2018 ◽  
Vol 15 (3) ◽  
pp. 14-20
Author(s):  
Yassine Chahirou ◽  
Abdelhalim Mesfioui ◽  
Ali Ouichou ◽  
Aboubaker Hessni
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Behavioral Disorders ◽  
Health Problems ◽  
Endocrine Tissue ◽  
Physiological Functions ◽  
Relationship Of ◽  
The Relationship

Current studies show that metabolic and behavioral disorders represent severe health problems. Several questions arise about the molecular relationship of metabolic and behavioral disorders. This review will discuss the relationship of lipid metabolism and fructose consumption accompanied by an increase in weight as well as associated disorders: hypertension, insulin-resistance, oxidative stress and depression. Adipose tissue is considered as an endocrine tissue with intense secretory activities (metabolic and inflammatory). These adipokines are responsible for an alteration of several physiological functions. In this review we will try to understand how lipogenesis that causes dyslipidemia can influence insulin resistance, hypertension, oxidative stress, depression and the relationship between these various disorders.

The relationship of oxidative stress markers and parameters of myocardial function in a rat model of cardiotoxicity

2014 ◽  
Vol 75 ◽  
pp. S42 ◽  
Author(s):  
Premysl Mladenka ◽  
Tomáš Filipský ◽  
Michal Ríha ◽  
Jaroslava Vávrová ◽  
Magdalena Holecková ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Myocardial Function ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Relationship Of ◽  
The Relationship

Circulating Chemerin, Oxidative Stress, Inflammation and Insulin Resistance in Morbid Obesity

2017 ◽  
Vol 68 (5) ◽  
pp. 1014-1018 ◽  
Author(s):  
Viviana Aursulesei ◽  
Siminela Bulughiana ◽  
Bogdan Alexandru Stoica ◽  
Ecaterina Anisie
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Morbid Obesity ◽  
Independent Predictor ◽  
Metabolic Phenotype ◽  
Morbidly Obese ◽  
Pathophysiological Role ◽  
Obese Subjects ◽  
Relationship Of ◽  
The Relationship

Chemerin is a relatively novel adipokine with controversial pathophysiological role in obesity. Our study aimed to investigate the relationship of serum chemerin level with inflammation, oxidative stress and insulin resistance in morbidly obese subjects. Circulating chemerin was an independent predictor of TNF-Q level, superoxide dismutase activity and lipid peroxidation, but no relation with insulin resistance could be sustained. Taken together chemerin could be a marker of dysfunctional adipose tissue, but its serum level does not reflect properly the metabolic phenotype in morbid obesity.

scholarly journals Tryptophan Metabolism, Inflammation, and Oxidative Stress in Patients with Neurovascular Disease

Metabolites ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 208 ◽  
Author(s):  
Martin Hajsl ◽  
Alzbeta Hlavackova ◽  
Karolina Broulikova ◽  
Martin Sramek ◽  
Martin Maly ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ischemic Stroke ◽  
Study Groups ◽  
Healthy Controls ◽  
Vascular Events ◽  
Liquid Chromatography Tandem Mass ◽  
Important Player ◽  
Hydroxyanthranilic Acid ◽  
Relationship Of ◽  
The Relationship

Atherosclerosis is a leading cause of major vascular events, myocardial infarction, and ischemic stroke. Tryptophan (TRP) catabolism was recognized as an important player in inflammation and immune response having together with oxidative stress (OS) significant effects on each phase of atherosclerosis. The aim of the study is to analyze the relationship of plasma levels of TRP metabolites, inflammation, and OS in patients with neurovascular diseases (acute ischemic stroke (AIS), significant carotid artery stenosis (SCAS)) and in healthy controls. Blood samples were collected from 43 patients (25 with SCAS, 18 with AIS) and from 25 healthy controls. The concentrations of twelve TRP metabolites, riboflavin, neopterin (NEO, marker of inflammation), and malondialdehyde (MDA, marker of OS) were measured by liquid chromatography–tandem mass spectrometry (LC-MS/MS). Concentrations of seven TRP metabolites (TRP, kynurenine (KYN), 3-hydroxykynurenine (3-HK), 3-hydroxyanthranilic acid (3-HAA), anthranilic acid (AA), melatonin (MEL), tryptamine (TA)), NEO, and MDA were significantly different in the studied groups. Significantly lower concentrations of TRP, KYN, 3-HAA, MEL, TA, and higher MDA concentrations were found in AIS compared to SCAS patients. MDA concentration was higher in both AIS and SCAS group (p < 0.001, p = 0.004, respectively) compared to controls, NEO concentration was enhanced (p < 0.003) in AIS. MDA did not directly correlate with TRP metabolites in the study groups, except for 1) a negative correlation with kynurenine acid and 2) the activity of kynurenine aminotransferase in AIS patients (r = −0.552, p = 0.018; r = −0.504, p = 0.033, respectively). In summary, TRP metabolism is clearly more deregulated in AIS compared to SCAS patients; the effect of TRP metabolites on OS should be further elucidated.

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