Towards a rational design of resolving agents. Part II: Correlation between resolution results and physical properties of diastereomeric salts

2010 ◽  
Vol 109 (10) ◽  
pp. 523-528 ◽  
Author(s):  
A. D. van der Haest ◽  
H. Wynberg ◽  
F. J. J. Leusen ◽  
A. Bruggink
Keyword(s):  
Physical Properties ◽  
Rational Design ◽  
Diastereomeric Salts ◽  
Resolving Agents

Towards a rational design of resolving agents. Part III. structural study of two pairs of diastereomeric salts of ephedrine and a cyclic phosphoric acid

2010 ◽  
Vol 110 (1) ◽  
pp. 13-18 ◽  
Author(s):  
F. J. J. Leusen ◽  
H. J. Bruins Slot ◽  
J. H. Noordik ◽  
A. D. van der Haest ◽  
H. Wynberg ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Structural Study ◽  
Rational Design ◽  
Diastereomeric Salts ◽  
Resolving Agents

scholarly journals Experimental and theoretical explorations of nanocarriers’ multistep delivery performance for rational design and anticancer prediction

2021 ◽  
Vol 7 (6) ◽  
pp. eaba2458
Author(s):  
Weier Bao ◽  
Falin Tian ◽  
Chengliang Lyu ◽  
Bin Liu ◽  
Bin Li ◽  
...  
Keyword(s):  
Physical Properties ◽  
Rational Design ◽  
Theoretical Models ◽  
Cell Uptake ◽  
Anticancer Efficacy ◽  
Delivery Performance ◽  
Simulation Based ◽  
Multistep Process

The poor understanding of the complex multistep process taken by nanocarriers during the delivery process limits the delivery efficiencies and further hinders the translation of these systems into medicine. Here, we describe a series of six self-assembled nanocarrier types with systematically altered physical properties including size, shape, and rigidity, as well as both in vitro and in vivo analyses of their performance in blood circulation, tumor penetration, cancer cell uptake, and anticancer efficacy. We also developed both data and simulation-based models for understanding the influence of physical properties, both individually and considered together, on each delivery step and overall delivery process. Thus, beyond finding that nanocarriers that are simultaneously endowed with tubular shape, short length, and low rigidity outperformed the other types, we now have a suit of theoretical models that can predict how nanocarrier properties will individually and collectively perform in the multistep delivery of anticancer therapies.

Evaluating a novel dimensional reduction approach for mechanical fractionation of cells using a tandem flexible micro spring array (tFMSA)

Lab on a Chip ◽  
2017 ◽  
Vol 17 (4) ◽  
pp. 691-701 ◽  
Author(s):  
Yin-Ting Yeh ◽  
Ramdane A. Harouaka ◽  
Si-Yang Zheng
Keyword(s):  
Physical Properties ◽  
Dimensional Reduction ◽  
Rational Design ◽  
Experimental Models ◽  
Cell Fractionation ◽  
Reduction Approach

We present a novel methodology to establish experimental models for the rational design of cell fractionation based on physical properties of cells.

scholarly journals Microwave-Assisted Synthesis of(±)-Mandelic Acid-d5, Optical Resolution, and Absolute Configuration Determination

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Claudio Bruno ◽  
Giovanni Lentini ◽  
Angelo Lovece ◽  
Maria Maddalena Cavalluzzi ◽  
Alessia Carocci ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Mandelic Acid ◽  
Optical Resolution ◽  
Racemic Mixture ◽  
Microwave Assisted Synthesis ◽  
Salt Formation ◽  
Microwave Assisted ◽  
Diastereomeric Salts ◽  
Chiral Capillary Electrophoresis ◽  
Resolving Agents

An efficient microwave-assisted synthesis of(±)-mandelic acid-d5was developed. The racemic mixture was resolved by diastereomeric salt formation using 1-phenylethylamine enantiomers as resolving agents. At each step, the resolution process was checked by determining mandelic acid-d5enantiomer ee values directly on fractional crystallized diastereomeric salts by chiral capillary electrophoresis analysis. Highly enriched (−)- and (+)-mandelic acid-d5(95% and 90% ee, resp.) were obtained and their absolute configurations—RandS, respectively—were determined by correlation of the (−)-mandelic acid-d5circular dichroism spectrum to the (R)-mandelic acid one.

Additional Article Notification: Rational design and applications of conducting polymer hydrogels as electrochemical biosensors

2015 ◽  
Vol 3 (25) ◽  
pp. 5111-5121 ◽  
Author(s):  
Lanlan Li ◽  
Ye Shi ◽  
Lijia Pan ◽  
Yi Shi ◽  
Guihua Yu
Keyword(s):  
Physical Properties ◽  
Water Content ◽  
Conducting Polymer ◽  
Rational Design ◽  
High Water ◽  
High Water Content ◽  
Electrochemical Biosensors ◽  
Polymer Hydrogels ◽  
Extracellular Environment

Conducting polymer hydrogels (CPHs) are conducting polymer-based materials that contain high water content and have physical properties, resembling the extracellular environment.

Three-Dimensional Morphology of Carbon Black in NR Vulcanizates as Revealed by 3D-Tem and Dielectric Measurements

2006 ◽  
Vol 79 (4) ◽  
pp. 653-673 ◽  
Author(s):  
Atsushi Kato ◽  
Junichi Shimanuki ◽  
Shinzo Kohjiya ◽  
Yuko Ikeda
Keyword(s):  
Carbon Black ◽  
Natural Rubber ◽  
Physical Properties ◽  
Rational Design ◽  
Electron Tomography ◽  
3D Visualization ◽  
Three Dimensional ◽  
Rubber Matrix ◽  
3D Images ◽  
Transmission Electron

Abstract Usual rubber products are a composite from rubber and nano-filler (e.g. carbon black, silica, etc.), and it is believed that the good dispersion of the nano-filler is the most important issue determining the performance of rubber vulcanizates. So far, transmission electron microscopy (TEM) has been the most useful tool for evaluation of the dispersion. However, it affords images of the sample projected on an x, y-plane, and the information along the thickness (z-axis) direction is missing. Three-dimensional (3D) visualization of nanometer structure of nano-filler dispersion in a rubber matrix is what all rubber technologists have been dreaming of. This dream is at last realized, and described in this paper. Use of TEM combined with computerized tomography (abbreviated as 3D-TEM in this paper, which is sometimes called electron tomography) enabled us to reconstruct 3D images of nano-filler aggregates in rubbery matrix. The 3D-TEM results on carbon black in natural rubber were presented in this paper. The network structure formed by agglomeration of carbon black aggregates was elucidated by combining the 3D images and physical properties of the vulcanizates. Density, electrical resistivity and dielectric relaxation of carbon black loaded natural rubber as an example of physical properties, were measured, and explained by the structure elucidated by 3D-TEM. This technique will prove to be more and more important for the rational design of the nano-composites of rubbery matrix.

Rational design and applications of conducting polymer hydrogels as electrochemical biosensors

2015 ◽  
Vol 3 (15) ◽  
pp. 2920-2930 ◽  
Author(s):  
Lanlan Li ◽  
Ye Shi ◽  
Lijia Pan ◽  
Yi Shi ◽  
Guihua Yu
Keyword(s):  
Physical Properties ◽  
Water Content ◽  
Conducting Polymer ◽  
Rational Design ◽  
High Water ◽  
High Water Content ◽  
Electrochemical Biosensors ◽  
Polymer Hydrogels ◽  
Extracellular Environment

Conducting polymer hydrogels (CPHs) are conducting polymer-based materials that contain high water content and have physical properties, resembling the extracellular environment.

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