scholarly journals Localized circumferential narrowed bronchial wall lesions in allergic bronchopulmonary aspergillosis

2020 ◽  
Vol 8 (6) ◽  
Author(s):  
Yurina Murakami ◽  
Yoshihiro Kitahara ◽  
Tomohiro Uto ◽  
Jun Sato ◽  
Shiro Imokawa ◽  
...  
Keyword(s):  
Allergic Bronchopulmonary Aspergillosis ◽  
Bronchial Wall ◽  
Wall Lesions

EUS is necessary for differential diagnosis in patients with Suspicious Gallbladder Wall Lesions

Endoscopy ◽  
2006 ◽  
Vol 39 (S 1) ◽  
Author(s):  
SH Lee ◽  
SM Woo ◽  
JW Yoo ◽  
JK Park ◽  
JK Ryu ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Gallbladder Wall ◽  
Wall Lesions

scholarly journals Allergic Diseases Caused by Aspergillus Species in Patients with Cystic Fibrosis

Antibiotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 357
Author(s):  
Aidan K. Curran ◽  
David L. Hava
Keyword(s):  
Cystic Fibrosis ◽  
Fungal Infections ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Hyphal Growth ◽  
Allergic Diseases ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Th2 Immune Response ◽  
Difficulty Breathing ◽  
Oral Corticosteroids

Aspergillus spp. are spore forming molds; a subset of which are clinically relevant to humans and can cause significant morbidity and mortality. A. fumigatus causes chronic infection in patients with chronic lung disease such as asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). In patients with CF, A. fumigatus infection can lead to allergic disease, such as allergic bronchopulmonary aspergillosis (ABPA) which is associated with high rates of hospitalizations for acute exacerbations and lower lung function. ABPA results from TH2 immune response to Aspergillus antigens produced during hyphal growth, marked by high levels of IgE and eosinophil activation. Clinically, patients with ABPA experience difficulty breathing; exacerbations of disease and are at high risk for bronchiectasis and lung fibrosis. Oral corticosteroids are used to manage aspects of the inflammatory response and antifungal agents are used to reduce fungal burden and lower the exposure to fungal antigens. As the appreciation for the severity of fungal infections has grown, new therapies have emerged that aim to improve treatment and outcomes for patients with CF.

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