scholarly journals A case of secondary pulmonary alveolar proteinosis, but prior to myelodysplastic syndrome

2013 ◽  
Vol 1 (2) ◽  
pp. 58-61
Author(s):  
Yunfeng Zhao ◽  
Wei Xiong ◽  
Xueling Wu
Keyword(s):  
Myelodysplastic Syndrome ◽  
Pulmonary Alveolar Proteinosis ◽  
Alveolar Proteinosis ◽  
Secondary Pulmonary Alveolar Proteinosis

scholarly journals Secondary pulmonary alveolar proteinosis associated with myelodysplastic syndrome

2007 ◽  
Vol 120 (12) ◽  
pp. 1114-1116 ◽  
Author(s):  
Li-xin XIE ◽  
Tie-mei ZHAO ◽  
Qiao-yun WANG ◽  
Liang-an CHEN ◽  
Ai-min LI ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Pulmonary Alveolar Proteinosis ◽  
Alveolar Proteinosis ◽  
Secondary Pulmonary Alveolar Proteinosis

scholarly journals Secondary pulmonary alveolar proteinosis during corticosteroid therapy for organising pneumonia associated with myelodysplastic syndrome

2019 ◽  
Vol 12 (9) ◽  
pp. e231055 ◽  
Author(s):  
Daiki Inoue ◽  
Satoshi Marumo ◽  
Haruyuki Ishii ◽  
Motonari Fukui
Keyword(s):  
Myelodysplastic Syndrome ◽  
Corticosteroid Therapy ◽  
Amorphous Materials ◽  
Pulmonary Alveolar Proteinosis ◽  
Periodic Acid ◽  
Radiological Findings ◽  
Periodic Acid Schiff ◽  
Gm Csf ◽  
Alveolar Proteinosis ◽  
Secondary Pulmonary Alveolar Proteinosis

Myelodysplastic syndrome (MDS) is frequently complicated by pulmonary disease. Here, we describe secondary pulmonary alveolar proteinosis (sPAP) that developed during corticosteroid therapy for organising pneumonia (OP) associated with MDS. A 75-year-old woman with MDS complained of cough for 2 weeks. Chest CT showed bilateral patchy consolidations with reversed halo sign. Bronchoalveolar lavage (BAL) examination showed remarkably increased cell density with an increased lymphocyte proportion. Abnormal radiological findings improved rapidly on administration of systemic corticosteroid under the diagnosis of OP; however, they relapsed a few weeks later. Transbronchial lung biopsy showed periodic acid-Schiff stain-positive amorphous materials. Autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF) in serum and BAL fluid (BALF) were both negative, while GM-CSF level in BALF was elevated. The patient was diagnosed with sPAP. When chest radiological findings show exacerbation during corticosteroid therapy for OP in a patient with MDS, physicians should consider sPAP complication as a differential diagnosis.

scholarly journals Secondary Pulmonary Alveolar Proteinosis Following Treatment with Azacitidine for Myelodysplastic Syndrome

2020 ◽  
Vol 59 (8) ◽  
pp. 1081-1086 ◽  
Author(s):  
Miki Hashimoto ◽  
Hidehiro Itonaga ◽  
Yasuhito Nannya ◽  
Hirokazu Taniguchi ◽  
Yuichi Fukuda ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Pulmonary Alveolar Proteinosis ◽  
Alveolar Proteinosis ◽  
Secondary Pulmonary Alveolar Proteinosis
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