scholarly journals Ageing contributes to phenotype transition in a mouse model of periodic paralysis

2021 ◽  
Author(s):  
Karen J. Suetterlin ◽  
S. Veronica Tan ◽  
Roope Mannikko ◽  
Rahul Phadke ◽  
Michael Orford ◽  
...  
Keyword(s):  
Mouse Model ◽  
Periodic Paralysis ◽  
Phenotype Transition

scholarly journals A Skeletal Muscle Conditional KCNJ2 Knock-Out Mouse Model for Periodic Paralysis in Andersen-Tawil Syndrome

2019 ◽  
Vol 116 (3) ◽  
pp. 242a
Author(s):  
Nathaniel Elia ◽  
Ekaterina Mokhonova ◽  
Marbella Quinonez ◽  
Stephen Cannon
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Periodic Paralysis ◽  
Knock Out ◽  
Knock Out Mouse

scholarly journals Physiological basis for muscle stiffness and weakness in a knock-in M1592V mouse model of hyperkalemic periodic paralysis

2015 ◽  
Vol 3 (12) ◽  
pp. e12656 ◽  
Author(s):  
Shiemaa Khogali ◽  
Brooke Lucas ◽  
Tarek Ammar ◽  
Danica Dejong ◽  
Michael Barbalinardo ◽  
...  
Keyword(s):  
Mouse Model ◽  
Periodic Paralysis ◽  
Muscle Stiffness ◽  
Hyperkalemic Periodic Paralysis ◽  
Physiological Basis

scholarly journals Beneficial effects of bumetanide in a CaV1.1-R528H mouse model of hypokalaemic periodic paralysis

Brain ◽  
2013 ◽  
Vol 136 (12) ◽  
pp. 3766-3774 ◽  
Author(s):  
Fenfen Wu ◽  
Wentao Mi ◽  
Stephen C. Cannon
Keyword(s):  
Mouse Model ◽  
Periodic Paralysis ◽  
Beneficial Effects ◽  
Hypokalaemic Periodic Paralysis

scholarly journals A sodium channel knockin mutant (NaV1.4-R669H) mouse model of hypokalemic periodic paralysis

2011 ◽  
Vol 121 (10) ◽  
pp. 4082-4094 ◽  
Author(s):  
Fenfen Wu ◽  
Wentao Mi ◽  
Dennis K. Burns ◽  
Yu Fu ◽  
Hillery F. Gray ◽  
...  
Keyword(s):  
Mouse Model ◽  
Sodium Channel ◽  
Periodic Paralysis ◽  
Hypokalemic Periodic Paralysis

scholarly journals A role for external Ca2+ in maintaining muscle contractility in periodic paralysis

2020 ◽  
Vol 152 (7) ◽  
Author(s):  
Stephen C. Cannon
Keyword(s):  
Mouse Model ◽  
Calcium Gluconate ◽  
Periodic Paralysis ◽  
Genetically Engineered ◽  
Muscle Contractility ◽  
Genetically Engineered Mouse Model

Calcium gluconate has been empirically administered to hasten recovery of force during an episode of periodic paralysis. By using a genetically engineered mouse model, Uwera and colleagues show that low Ca2+ clearly promotes a loss of force in affected muscle, thereby providing the first evidence for the benefit of maintaining normal Ca2+ levels in this disorder.

scholarly journals A calcium channel mutant mouse model of hypokalemic periodic paralysis

2012 ◽  
Vol 122 (12) ◽  
pp. 4580-4591 ◽  
Author(s):  
Fenfen Wu ◽  
Wentao Mi ◽  
Erick O. Hernández-Ochoa ◽  
Dennis K. Burns ◽  
Yu Fu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Calcium Channel ◽  
Mutant Mouse ◽  
Periodic Paralysis ◽  
Hypokalemic Periodic Paralysis

Regenerating myofibers in tibialis anterior muscles of young ‘MDX’ mice

1987 ◽  
Vol 45 ◽  
pp. 726-727
Author(s):  
H. D. Geissinge ◽  
L.D. Rhodes
Keyword(s):  
Muscular Dystrophy ◽  
Mouse Model ◽  
Tibialis Anterior ◽  
Physiological Activity ◽  
Mdx Mice ◽  
Mode Of Inheritance

A recently discovered mouse model (‘mdx’) for muscular dystrophy in man may be of considerable interest, since the disease in ‘mdx’ mice is inherited by the same mode of inheritance (X-linked) as the human Duchenne (DMD) muscular dystrophy. Unlike DMD, which results in a situation in which the continual muscle destruction cannot keep up with abortive regenerative attempts of the musculature, and the sufferers of the disease die early, the disease in ‘mdx’ mice appears to be transient, and the mice do not die as a result of it. In fact, it has been reported that the severely damaged Tibialis anterior (TA) muscles of ‘mdx’ mice seem to display exceptionally good regenerative powers at 4-6 weeks, so much so, that these muscles are able to regenerate spontaneously up to their previous levels of physiological activity.

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