Rapid Detection of Sulfur Mustard Hydrolysis Products based on Microextraction by Packed Sorbent combined with Nano‐ESI Mass Spectrometry

2021 ◽  
Author(s):  
Baoqiang Li ◽  
Jianan Wei ◽  
Jinglin Kong ◽  
Liu Yang ◽  
Cuiping Li
Keyword(s):  
Mass Spectrometry ◽  
Rapid Detection ◽  
Sulfur Mustard ◽  
Microextraction By Packed Sorbent ◽  
Hydrolysis Products ◽  
Esi Mass Spectrometry ◽  
Packed Sorbent

Determination of pesticides in sugarcane juice employing microextraction by packed sorbent followed by gas chromatography and mass spectrometry

2016 ◽  
Vol 39 (14) ◽  
pp. 2823-2830 ◽  
Author(s):  
Bruno Henrique Fumes ◽  
Felipe Nascimento Andrade ◽  
Álvaro José dos Santos Neto ◽  
Fernando Mauro Lanças
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Sugarcane Juice ◽  
Microextraction By Packed Sorbent ◽  
Packed Sorbent

scholarly journals Determination and Pharmacokinetics of Omeprazole Enantiomers in Human Plasma and Oral Fluid Utilizing Microextraction by Packed Sorbent and Liquid Chromatography-Tandem Mass Spectrometry

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Hytham Ahmed ◽  
Abdel-Aziz Wahbi ◽  
Hatem Elmongy ◽  
Ahmad Amini ◽  
Hirsh Koyi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Oral Fluid ◽  
Tandem Mass ◽  
Plasma Samples ◽  
Microextraction By Packed Sorbent ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Packed Sorbent

In the present work, the determination of omeprazole (OME) enantiomers in oral fluid and plasma samples was carried out utilizing microextraction by packed sorbent (MEPS) and liquid chromatography-tandem mass spectrometry. A chiral column with cellulose-SB phase was used for the first time for enantiomeric separation of OME with an isocratic elution system using 0.2% ammonium hydroxide in hexane-ethanol mixture (70 : 30, v/v) as the mobile phase. OME enantiomers were determined utilizing a triple quadrupole tandem mass spectrometer in positive ion mode (ESI+) monitoring mass transitions: m/z 346.3 ⟶ 198.0 for OME and m/z 369.98 ⟶ 252.0 for internal standard. The limits of detection and quantification of the present method for both enantiomers were 0.1 and 0.4 ng/mL, respectively. The method validation provided good accuracy and precision. The matrix effect factor was less than 5%, and no interfering peaks were observed. The interday precision values ranged from 2.2 to 7.5 (%RSD), and the accuracy of determinations varied from −9.9% to 8.3%. In addition, the pharmacokinetics (PK) of omeprazole enantiomers in healthy subjects after a single oral dose was investigated. (S)-Enantiomers showed higher levels than (R)-enantiomers throughout 24 h. It was found that the mean maximum concentrations of (R)- and (S)-omeprazole in plasma samples were about two times higher than in oral fluid.

Sign in / Sign up

Export Citation Format

Share Document