Comparative metabolism of gelsenicine in liver microsomes from humans, pigs, goats and rats

2020 ◽  
Vol 34 (17) ◽  
Author(s):  
Zi‐Yuan Wang ◽  
Ming‐Ting Zuo ◽  
Xue‐Jiao Zhao ◽  
Yu‐Juan Li ◽  
Zhi‐Liang Sun ◽  
...  
Keyword(s):  
Liver Microsomes ◽  
Comparative Metabolism

Comparative metabolism of DDAO benzoate in liver microsomes from various species

2017 ◽  
Vol 44 ◽  
pp. 280-286 ◽  
Author(s):  
Hong-Ying Ma ◽  
Jia-Da Yang ◽  
Jie Hou ◽  
Li-Wei Zou ◽  
Qiang Jin ◽  
...  
Keyword(s):  
Liver Microsomes ◽  
Comparative Metabolism

A comparison of the in vitro metabolism of biphenyl and 4-chlorobiphenyl by rat liver microsomes

1978 ◽  
Vol 56 (10) ◽  
pp. 993-997 ◽  
Author(s):  
C. Wyndham ◽  
S. Safe
Keyword(s):  
Polychlorinated Biphenyl ◽  
Liver Microsomes ◽  
Low Molecular Weight ◽  
Rat Liver Microsomes ◽  
Hepatic Microsomes ◽  
Comparative Metabolism ◽  
Metabolic Products ◽  
Active Substrate ◽  
And Control

The comparative metabolism of the hydrocarbons, biphenyl and 4-chlorobiphenyl, was investigated using two different preparations of rat hepatic microsomes. The assay was designed to account for all the metabolic products which included the ether soluble lipophilic metabolites, low molecular weight conjugates, and macromolecular adducts, and to determine the effects of induction with Aroclor 1254 and 1248, two commercial polychlorinated biphenyl (PCB) preparations. 4-Chlorobiphenyl was the more metabolically active substrate with the induced and control enzymes. In most metabolic fractions biphenyl was less inducible by the PCB's, with the exception of the 2-biphenylol metabolite which was induced ca. 18-fold. Preincubation of the microsomes with carcinogens did not enhance biphenyl 2-hydroxylation. Instead, a general inhibition of metabolic activity was observed for both biphenyl and 4-chlorobiphenyl substrates. Preincubation with phenobarbitone, a noncarcinogen, did not change the microsome-mediated metabolism of biphenyl or 4-chlorobiphenyl. The substitution of a single halogen atom on the biphenyl nucleus altered both the reactivity and pattern of metabolites for these substrates.

Comparative metabolism of 7H-dibenzo[c,g]carbazole and dibenz[a,j]acridine by mouse and rat liver microsomes

1992 ◽  
Vol 81 (1-2) ◽  
pp. 131-147 ◽  
Author(s):  
Liping Wan ◽  
Weiling Xue ◽  
Joanne Schneider ◽  
Ray Reilman ◽  
Martha Radike ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Rat Liver Microsomes ◽  
Comparative Metabolism

Comparative metabolism of benzo[ƒ]quinoline by liver microsomes from brown bullheads and rats

1989 ◽  
Vol 93 (2) ◽  
pp. 269-274 ◽  
Author(s):  
Chithan Kandaswami ◽  
Joel P. Rutkowski ◽  
Subodh Kumar ◽  
Harish C. Sikka
Keyword(s):  
Liver Microsomes ◽  
Comparative Metabolism

Comparative metabolism of benzo(a)pyrene, chrysene and phenanthrene by brown bullhead liver microsomes

1995 ◽  
Vol 39 (1-4) ◽  
pp. 51-55 ◽  
Author(s):  
Jyotsna Pangrekar ◽  
Chithan Kandaswami ◽  
Panna Kole ◽  
Subodh Kumar ◽  
Harish C. Sikka
Keyword(s):  
Liver Microsomes ◽  
Brown Bullhead ◽  
Comparative Metabolism

Comparative metabolism of insecticide carbosulfan by human, mouse and rat liver microsomes

2007 ◽  
Vol 172 ◽  
pp. S211 ◽  
Author(s):  
Jeong Han Kim ◽  
Chul-Hee Chang ◽  
Joon-Kwan Moon ◽  
Hwa-Gyung Lee ◽  
Joo-Hee Lee ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Rat Liver Microsomes ◽  
Comparative Metabolism

scholarly journals Comparative Metabolism of Milbemycin A3 and A4 in Rat Liver Microsomes

1992 ◽  
Vol 17 (3) ◽  
pp. 199-203 ◽  
Author(s):  
Shingo SADAKANE ◽  
Keiji TANAKA ◽  
Kazuo SATO ◽  
Mitsuru ANDO
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Rat Liver Microsomes ◽  
Comparative Metabolism
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