Peptidyl‐Lys metalloendopeptidase (Lys‐N) purified from dry fruit of Grifola frondosa demonstrates “mirror”digestion property with lysyl endopeptidase (Lys‐C)

2020 ◽  
Vol 34 (2) ◽  
Author(s):  
Mingzhi Zhao ◽  
Bingbing Hao ◽  
Honghao Li ◽  
Man Cai ◽  
Jingjing Xie ◽  
...  
Keyword(s):  
Grifola Frondosa ◽  
Lysyl Endopeptidase ◽  
Dry Fruit

Anticancer and Hypoglycemic Effects of Polysaccharides in Edible and Medicinal Maitake Mushroom [Grifola frondosa (Dicks.: Fr.) S. F. Gray]

2002 ◽  
Vol 4 (3) ◽  
pp. 11 ◽  
Author(s):  
Sensuke Konno ◽  
Shahrad Aynehchi ◽  
Daniele J. Dolin ◽  
Alec M. Schwartz ◽  
Muhammad S. Choudhury ◽  
...  
Keyword(s):  
Grifola Frondosa ◽  
Maitake Mushroom

scholarly journals A specific selenium-chelating peptide isolated from the protein hydrolysate of Grifola frondosa

RSC Advances ◽  
2021 ◽  
Vol 11 (17) ◽  
pp. 10272-10284
Author(s):  
Yu Xiong ◽  
Zi-Hong Chen ◽  
Feng-Li Zhang ◽  
Zhi-Ying Yu ◽  
Bin Liu ◽  
...  
Keyword(s):  
Protein Hydrolysate ◽  
Grifola Frondosa

A selenium chelating peptide was isolated and purified from Grifola frondosa hydrolysate, which may be a promising selenium supplement.

Anti-obesity effects of Grifola frondosa through the modulation of lipid metabolism via ceramide in mice fed a high-fat diet

2021 ◽  
Author(s):  
Xue Jiang ◽  
Jie Hao ◽  
Zijian Liu ◽  
Xueting Ma ◽  
Yuxin Feng ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Lipid Metabolism ◽  
High Fat Diet ◽  
Fat Deposition ◽  
Grifola Frondosa ◽  
High Fat ◽  
Metabolic Complications ◽  
Basidiomycete Fungus

Obesity is characterized by massive fat deposition and is related to a series of metabolic complications, such as insulin resistance (IR) and steatohepatitis. Grifola frondosa (GF) is a basidiomycete fungus...

scholarly journals Anti-Inflammatory and Immunomodulatory Effects of the Grifola frondosa Natural Compound o-Orsellinaldehyde on LPS-Challenged Murine Primary Glial Cells. Roles of NF-κβ and MAPK

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 806
Author(s):  
Sarah Tomas-Hernandez ◽  
Jordi Blanco ◽  
Santiago Garcia-Vallvé ◽  
Gerard Pujadas ◽  
María José Ojeda-Montes ◽  
...  
Keyword(s):  
Natural Compound ◽  
Underlying Disease ◽  
Grifola Frondosa ◽  
Beneficial Effects ◽  
Inflammatory Conditions ◽  
Inflammatory Mechanism ◽  
Inflammatory Phenotype ◽  
Mice Brain ◽  
Anti Inflammatory

In response to foreign or endogenous stimuli, both microglia and astrocytes adopt an activated phenotype that promotes the release of pro-inflammatory mediators. This inflammatory mechanism, known as neuroinflammation, is essential in the defense against foreign invasion and in normal tissue repair; nevertheless, when constantly activated, this process can become detrimental through the release of neurotoxic factors that amplify underlying disease. In consequence, this study presents the anti-inflammatory and immunomodulatory properties of o-orsellinaldehyde, a natural compound found by an in silico approach in the Grifola frondosa mushroom, in astrocytes and microglia cells. For this purpose, primary microglia and astrocytes were isolated from mice brain and cultured in vitro. Subsequently, cells were exposed to LPS in the absence or presence of increasing concentrations of this natural compound. Specifically, the results shown that o-orsellinaldehyde strongly inhibits the LPS-induced inflammatory response in astrocytes and microglia by decreasing nitrite formation and downregulating iNOS and HO-1 expression. Furthermore, in microglia cells o-orsellinaldehyde inhibits NF-κB activation; and potently counteracts LPS-mediated p38 kinase and JNK phosphorylation (MAPK). In this regard, o-orsellinaldehyde treatment also induces a significant cell immunomodulation by repolarizing microglia toward the M2 anti-inflammatory phenotype. Altogether, these results could partially explain the reported beneficial effects of G. frondosa extracts on inflammatory conditions.

scholarly journals Grifola frondosa GF5000 improves insulin resistance by modulation the composition of gut microbiota in diabetic rats

2021 ◽  
Vol 77 ◽  
pp. 104313
Author(s):  
Chun Xiao ◽  
Chunwei Jiao ◽  
Yizhen Xie ◽  
Linhui Ye ◽  
Qianqing Li ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gut Microbiota ◽  
Diabetic Rats ◽  
Grifola Frondosa

Structural characterisation of a neutral antitumour β-d-glucan extracted with hot sodium hydroxide from cultured fruit bodies of Grifola frondosa

1985 ◽  
Vol 141 (1) ◽  
pp. 111-119 ◽  
Author(s):  
Kazuyoshi Iino ◽  
Naohito Ohno ◽  
Iwao Suzuki ◽  
Toshio Miyazaki ◽  
Toshiro Yadomae ◽  
...  
Keyword(s):  
Sodium Hydroxide ◽  
Grifola Frondosa ◽  
Structural Characterisation
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