A false positive finding in liquid chromatography/triple quadrupole mass spectrometry analysis by a non-isobaric matrix component: the case of benzotriazole in urine for human biomonitoring

2016 ◽  
Vol 30 (13) ◽  
pp. 1560-1566 ◽  
Author(s):  
Linda Schlittenbauer ◽  
Bettina Seiwert ◽  
Thorsten Reemtsma
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Human Biomonitoring ◽  
Mass Spectrometry Analysis ◽  
Positive Finding ◽  
Triple Quadrupole ◽  
Quadrupole Mass ◽  
Matrix Component ◽  
False Positive Finding ◽  
Spectrometry Analysis

scholarly journals Gas Chromatography-Triple Quadrupole Mass Spectrometry Analysis and Vasorelaxant Effect of Essential Oil fromProtium heptaphyllum(Aubl.) March.

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Mitra Mobin ◽  
Sidney G. de Lima ◽  
Lorena T. G. Almeida ◽  
José C. Silva Filho ◽  
Márcio S. Rocha ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Essential Oil ◽  
Mass Spectrometry Analysis ◽  
Triple Quadrupole ◽  
Quadrupole Mass ◽  
Triple Quadrupole Mass Spectrometry ◽  
Spectrometry Analysis ◽  
Quadrupole Mass Spectrometry ◽  
Vasorelaxant Effect

TheProtium heptaphyllumspecies, also known as Almécega, produces an oily resin, used in folk medicine as an analgesic and anti-inflammatory agent, in healing, and as an expectorant, which is rich in pentacyclic triterpenes and essential oils. In this study, the essential oil obtained by hydrodistillation of Almécega’s resin was analyzed by gas chromatography-triple quadrupole mass spectrometry and evaluated for chemical composition and vasorelaxant activity in rat superior mesenteric artery. The main constituents determined by gas chromatography-triple quadrupole mass spectrometry were limonene,p-cineole, ando-cymene. In intact rings precontracted with phenylephrine (Phe 1 μM), EOPh (3–750 μg/mL) induced relaxation, and the essential oil had a concentration-dependent vasorelaxant effect, without involvement of endothelial mediators.

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