Product ion filtering with rapid polarity switching for the detection of all fumonisins and AAL-toxins

2015 ◽  
Vol 29 (22) ◽  
pp. 2131-2139 ◽  
Author(s):  
Justin B. Renaud ◽  
Megan J. Kelman ◽  
Tianyu F. Qi ◽  
Keith A. Seifert ◽  
Mark W. Sumarah
Keyword(s):  
Polarity Switching ◽  
Aal Toxins

scholarly journals Systematic Profiling of the Multicomponents and Authentication of Erzhi Pill by UHPLC/Q-Orbitrap-MS Oriented Rapid Polarity-Switching Data-Dependent Acquisition and Selective Monitoring of the Chemical Markers Deduced from Fingerprint Analysis

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3143 ◽  
Author(s):  
Li Jia ◽  
Lingling Fu ◽  
Xiaoyan Wang ◽  
Wenzhi Yang ◽  
Hongda Wang ◽  
...  
Keyword(s):  
High Efficiency ◽  
High Energy ◽  
Composition Analysis ◽  
Chemical Markers ◽  
Polarity Switching ◽  
Selective Ion Monitoring ◽  
Marker Compounds ◽  
Full Scan ◽  
Selective Monitoring ◽  
Orbitrap Ms

The analytical platform UHPLC/Q-Orbitrap-MS offers a solution to quality investigation of TCM with high definiteness. Using Erzhi Pill (EZP) as a case, we developed UHPLC/Q-Orbitrap-MS based approaches to achieve systematic multicomponent identification and rapid authentication. Comprehensive multicomponent characterization of EZP was performed by negative/positive switching data-dependent high-energy collision-induced dissociation-MS2 (HCD-MS2) after 25 min chromatographic separation. By reference compounds comparison, elemental composition analysis, fragmentation pathways interpretation, and retrieval of an in-house library, 366 compounds were separated and detected from EZP, and 96 thereof were structurally characterized. The fingerprints of two component drugs (Ligustri Lucidi Fructus, LLF; Ecliptae Herba, EH) for EZP were analyzed under the same LC-MS condition by full scan in negative mode. In combination with currently available pharmacological reports, eight compounds were deduced as the ‘identity markers’ of EZP. Selective ion monitoring (SIM) of eight marker compounds was conducted to authenticate six batches of EZP samples. Both LLF and EH could be detected from all EZP samples by analyzing the SIM spectra, which could indicate their authenticity. Conclusively, UHPLC/Q-Orbitrap-MS by rapid polarity switching could greatly expand the potency of untargeted profiling with high efficiency, and SIM of multiple chemical markers rendered a practical approach enabling the authentication of TCM formulae.

scholarly journals Simultaneous determination of tryptophan and its 31 catabolites in mouse tissues by polarity switching UHPLC-SRM-MS

2018 ◽  
Vol 1037 ◽  
pp. 200-210 ◽  
Author(s):  
Guan-yuan Chen ◽  
Wei Zhong ◽  
Zhanxiang Zhou ◽  
Qibin Zhang
Keyword(s):  
Simultaneous Determination ◽  
Mouse Tissues ◽  
Polarity Switching

Temperature and water activity influence on simultaneous production of AAL toxins by Alternaria arborescens on tomato medium

2017 ◽  
Vol 148 (4) ◽  
pp. 1003-1009 ◽  
Author(s):  
Sandra Vaquera ◽  
Andrea Patriarca ◽  
Gabriela Cabrera ◽  
Virginia Fernández Pinto
Keyword(s):  
Water Activity ◽  
Simultaneous Production ◽  
Alternaria Arborescens ◽  
Aal Toxins

Polarity switching from p- to n-type in a single thermoelectric donor-acceptor copolymer by p-type doping

2021 ◽  
Author(s):  
Jing Wang ◽  
Yizhuo Wang ◽  
Qing Li ◽  
Zhanchao Li ◽  
Liqing Xu ◽  
...  
Keyword(s):  
Conducting Polymer ◽  
High Performance ◽  
High Current Density ◽  
Organic Polymer ◽  
Novel Approach ◽  
Polarity Switching ◽  
Electrical Conductivities ◽  
Planar Film ◽  
Donor Acceptor ◽  
P Type

Abstract The transport mechanism of organic materials is still far away from being well understood and controlled although conducting polymers have been discovered since 1977. It is rare to see conducting polyers possessing high bipolar (p- and n-type) electrical conductivities within a single bulk doped organic polymer without the assistant of gate voltage. Here, we report a novel approach to provide high performance n-type materials by p-type doping. More importantly, the bipolar electrical conductivities of the donor-acceptor conducting polymer are high, resulting high bipolar power factors among the solution-processable ambipolar D-A copolymers. A fully organic p-n junction is created in a planar film, exhibiting a high rectification ratio of 2 x 102 at +5 V with a high current density of 3 A/cm2. Structural and spectroscopic tests have been performed to provide a fundamental understanding of the polarity switching mechanism. The results open the opportunity of making p- and n-type modules with a single conducting polymer for future modern organic electronics.

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