The use of a membrane filtration device to form dried plasma spots for the quantitative determination of guanfacine in whole blood

2012 ◽  
Vol 26 (10) ◽  
pp. 1208-1212 ◽  
Author(s):  
Yuanyuan Li ◽  
Jack Henion ◽  
Richard Abbott ◽  
Phillip Wang
1972 ◽  
Vol 18 (11) ◽  
pp. 1343-1349 ◽  
Author(s):  
Rodney G Cooper ◽  
Mavis S Greaves ◽  
Goronwy Owen

Abstract An accurate method is described for the qualitative and quantitative determination of 11 barbiturates, glutethimide, and diphenylhydantoin in a single extract obtained from 1 ml of whole blood, which is extracted with ether at pH 2 and separately but simultaneously gas-liquid chromatographed on a selective (3% OV-17) and a nonselective (5% OV-1) column. Retention data are given. Results for barbiturate obtained by the Broughton [Biochem. J.63, 207 (1956)] spectrophotometric method and this gas-liquid chromatographic method are compared. Blood from more than 30 patients has been analyzed, and data are given to illustrate some of the findings.


2015 ◽  
Vol 17 (5) ◽  
pp. 467 ◽  
Author(s):  
M. A. Gordukova ◽  
I. P. Oskorbin ◽  
O. V. Mishukova ◽  
S. B. Zimin ◽  
N. V. Zinovieva ◽  
...  

1974 ◽  
Vol 20 (2) ◽  
pp. 275-277 ◽  
Author(s):  
James C Valentour ◽  
Joseph R Monforte ◽  
Irving Sunshine

Abstract We report a sensitive fluorometric method of analysis of propoxyphene in biological materials. 4-Chloro-7-nitrobenzo-2,1,3-oxadiazole is reacted with propoxyphene to produce highly fluorescent derivatives, thus enabling quantitative determination of propoxyphene in whole blood, urine, or tissue after either therapeutic use or overdose.


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