Quantification of small molecules in plasma with direct analysis in real time tandem mass spectrometry, without sample preparation and liquid chromatographic separation

2008 ◽  
Vol 22 (20) ◽  
pp. 3217-3224 ◽  
Author(s):  
Yeping Zhao ◽  
Michelle Lam ◽  
Danlin Wu ◽  
Rowena Mak
Keyword(s):  
Mass Spectrometry ◽  
Sample Preparation ◽  
Tandem Mass Spectrometry ◽  
Small Molecules ◽  
Real Time ◽  
Chromatographic Separation ◽  
Direct Analysis ◽  
Tandem Mass ◽  
Liquid Chromatographic Separation ◽  
Liquid Chromatographic

Determination of ochratoxin A in wine by direct analysis in real time-tandem mass spectrometry

2017 ◽  
Vol 35 (2) ◽  
pp. 185 ◽  
Author(s):  
Xiaoming GONG ◽  
Ronghui MA ◽  
Hongtao WANG ◽  
Liqiang GUO ◽  
Kai LI ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Real Time ◽  
Ochratoxin A ◽  
Direct Analysis ◽  
Tandem Mass

scholarly journals Real-time monitoring of the reaction between aniline and acetonylacetone using extractive electorspray ionization tandem mass spectrometry

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Xinglei Zhang ◽  
Miaorong Pei ◽  
Debo Wu ◽  
Shuiping Yang ◽  
Zhanggao Le
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Real Time ◽  
Sample Pretreatment ◽  
Direct Analysis ◽  
Molecular Ions ◽  
Tandem Mass ◽  
Monitoring Method ◽  
On Line ◽  
Ionization Tandem Mass Spectrometry

AbstractIn this work an on-line monitoring method was developed to study the mechanism of acetic acid catalyzed reaction between aniline and acetonylacetone using extractive electorspray ionization-tandem mass spectrometry (EESI-MS). The signals of reactants, intermediates and various byproducts were continuously detected as a function of reaction time. The chemical assignment of each signal was done via multi-stage collision induced dissociation (CID) analysis, and the reaction mechanism between aniline and acetonylacetone was deduced based on the generated molecular ions and fragment ions. The results indicate that on-line EESI-MS is an effective technique for the real time analysis of chemical reactions. EESI avoids off-line sample pretreatment and provides “soft” ionization, which allows direct analysis of various analytes at molecular level.

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