Role of the support material on laser desorption/ionization mass spectra

2008 ◽  
Vol 22 (7) ◽  
pp. 925-929 ◽  
Author(s):  
A. Gruszecka ◽  
M. Szymanska-Chargot ◽  
A. Smolira ◽  
J. Cytawa ◽  
L. Michalak
Keyword(s):  
Mass Spectra ◽  
Laser Desorption ◽  
Ionization Mass ◽  
Support Material ◽  
Laser Desorption Ionization ◽  
Desorption Ionization

Multiscale analysis of Jurassic rocks with sulfur-rich organic matter using laser desorption/ionization mass spectrometry

2021 ◽  
Author(s):  
Siveen Thlaijeh ◽  
Kevin Lepot ◽  
Yvain Carpentier ◽  
Dumitru Duca ◽  
Dmitrii Egorov ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Organic Matter ◽  
Mass Spectra ◽  
Laser Desorption ◽  
Carbon Clusters ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Gale Crater ◽  
Desorption Ionization ◽  
Inorganic Species

<p>The Mars organic molecular analyzer (MOMA) of the Rosalind Franklin rover (ExoMars project) will combine laser desorption-ionization mass spectrometry (LDI-MS) and gas-chromatography mass spectrometry (GC-MS) to assess the origin of organic matter on planet Mars. In order to further assess the type of molecular information that can be retrieved with the former technique, we applied high-resolution laser two-step mass spectrometry (L2MS) to fossil organic matter of sedimentary rock from the Jurassic deposit of Orbagnoux, France. Abundant sulfur-rich microbial organic matter has been thoroughly documented in this deposit [1]. This sample has been chosen following the detection of thiophenes at Gale Crater on Mars by the Sample analysis at Mars (SAM) instrument [2]. In our L2MS instrument [3], the samples are irradiated with a pulsed desorption laser (532 or 266 nm), which generates a plume of chemical species that can be further ionized with a second orthogonal laser beam (266 nm). A radiofrequency ion guide is used to carry the ions to an orthogonal time-of-flight mass spectrometer (oToF-MS system by Fasmatech), yielding high-resolution mass spectra (m/Δm ~10000 at 128 m/z). Focusing of the desorption laser using a reflective objective and automated micro-positioning of the sample were used to generate hyperspectral raster mappings. Subsamples included solvent-extracted molecules (bitumen and maltene fractions), insoluble macromolecular organic matter (kerogen), rock powder and a polished slice. Our analyses showed that we can extract chemical information with LDI-MS from both soluble and insoluble organic fractions of the Orbagnoux samples and that various chemical families can be distinguished even in mineralized samples. Carbon clusters, including sulfurated and hydrogenated species could be detected in all subsamples. With the exception of the rock slice, polyaromatic hydrocarbons could be detected in all samples. Oxygenated molecules and alkylbenzenes could only be detected in extracts, which generated rich and intense mass spectra. Various inorganic ions were also generated in all sample fractions. Using focused desorption beams, carbon clusters (including sulfurated clusters) and inorganic species could be detected and mapped in the polished slice with <50 µm lateral resolution. L2MS thus shows great promise for fast screening of organic/inorganic species on Mars, and for microanalyses applied to paleontological questions.</p><p>[1] Mongenot, T., Derenne, S., Largeau, C., Tribovillard, N.P., Lallier-Vergès, E., Dessort, D., Connan, J., 1999. Spectroscopic, kinetic and pyrolytic studies of kerogen from the dark parallel laminae facies of the sulphur-rich Orbagnoux deposit (Upper Kimmeridgian, Jura). Org. Geochem. 30, 39–56. </p><p>[2] Eigenbrode, J.L., Summons, R.E., Steele, A., Freissinet, C., Millan, M., Navarro-González, R., Sutter, B., McAdam, A.C., Franz, H.B., Glavin, D.P., Archer, P.D., Mahaffy, P.R., Conrad, P.G., Hurowitz, J.A., Grotzinger, J.P., Gupta, S., Ming, D.W., Sumner, D.Y., Szopa, C., Malespin, C., Buch, A., Coll, P., 2018. Organic matter preserved in 3-billion-year-old mudstones at Gale crater, Mars. Science (80-. ). 360, 1096–1101. </p><p>[3] A. Faccinetto, P. Desgroux, M. Ziskind, E. Therssen, C. Focsa, High-sensitivitydetection of polycyclic aromatic hydrocarbons adsorbed onto soot particles using laser desorption/laser ionization/time-of-flight mass spectrometry: An approach to studying the soot inception process in low-pressure flames, Combustion and Flame 158 (2011) 227–239. </p>

scholarly journals High-Performance Sample Substrate of Gold Nanoparticle Multilayers for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry

Nanomaterials ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 1078 ◽  
Author(s):  
Liu ◽  
Chang ◽  
Lin ◽  
Liou ◽  
Kuo
Keyword(s):  
Mass Spectrometry ◽  
Small Molecules ◽  
Mass Spectra ◽  
Laser Desorption ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Homogeneous Sample ◽  
Desorption Ionization ◽  
Saldi Ms

The development of a sample substrate with superior performance for desorption and ionization of analyte is the key issue to ameliorate the quality of mass spectra for measurements of small molecules in surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS). Herein, the homogeneous sample substrate of gold nanoparticle multilayers (AuNPs-ML) with hexagonal lattice was successfully prepared by self-assembly technique. With strong surface plasmon resonance absorption and superior photothermal effect, the sample substrate of AuNPs-ML exhibited high signal sensitivity and low background noise for the detection of model analyte of glucose without additional matrixes in SALDI-MS. Furthermore, compared to merchant matrixes of α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB), the sample substrate of AuNPs-ML was demonstrated to ameliorate the quality of mass spectra, including signal strength, background interference and signal/noise (S/N) ratio. The sucrose and tryptophan were also measured to show the extensive applications of AuNPs-ML sample substrate for the detections of small molecules in SALDI-MS. Most importantly, the remarkable reproducibility of glucose mass spectra with relative signal of 7.3% was obtained by the use of AuNPs-ML sample substrate for SALDI-MS. The homogeneous sample substrate of AuNPs-ML greatly improved the quality of mass spectra because of its strong absorption of laser energy, low specific heat, high heat conductivity and extraordinary homogeneity. We believe that AuNPs-ML could be a practical sample substrate for small molecule detection in SALDI-MS.

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