Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs

2007 ◽  
Vol 22 (2) ◽  
pp. 187-196 ◽  
Author(s):  
Jonathan P. Williams ◽  
James H. Scrivens
Keyword(s):  
Mass Spectrometer ◽  
Ion Mobility ◽  
Travelling Wave ◽  
Electrospray Ionisation

scholarly journals Characterisation of Anthracyclines from a Cosmomycin D-Producing Species of Streptomyces by Collisionally-Activated Dissociation and Ion Mobility Mass Spectrometry

2009 ◽  
Vol 15 (2) ◽  
pp. 73-81 ◽  
Author(s):  
Celine Kelso ◽  
Juan Diego Rojas ◽  
Renata L.A. Furlan ◽  
Gabriel Padilla ◽  
Jennifer L. Beck
Keyword(s):  
Mass Spectrometer ◽  
Ion Mobility ◽  
Ion Trap ◽  
Parent Compound ◽  
Quadrupole Ion Trap ◽  
Travelling Wave ◽  
Hydroxyl Groups ◽  
Exact Mass ◽  
Electrospray Ionisation ◽  
Collisionally Activated Dissociation

Cultures of cosmomycin D-producing Streptomyces olindensis ICB20 that were propagated for many generations underwent mutations that resulted in production of a range of related anthracyclines by the bacteria. The anthracyclines that retained the two trisaccharide chains of the parent compound were separated by HPLC. Exact mass determination of these compounds revealed that they differed from cosmomycin D (CosD) in that they contained one to three fewer oxygen atoms (loss of hydroxyl groups). Some of the anthracyclines that were separated by HPLC had the same mass. The location from which the hydroxyl groups had been lost relative to CosD (on the aglycone and/or on the sugar residues) was probed by collisionally-activated dissociation using an electrospray ionisation linear quadrupole ion trap mass spectrometer. The presence of anthracyclines with the same mass, but different structure, was confirmed using an electrospray ionisation travelling wave ion mobility mass spectrometer.

scholarly journals Identification of N-glycans with GalNAc-containing antennae from recombinant HIV trimers by ion mobility and negative ion fragmentation

2021 ◽  
Author(s):  
David J. Harvey ◽  
Anna-Janina Behrens ◽  
Max Crispin ◽  
Weston B. Struwe
Keyword(s):  
Cross Sections ◽  
Ion Mobility ◽  
Travelling Wave ◽  
Negative Ion ◽  
Ion Fragmentation ◽  
Structural Identity ◽  
Immunodeficiency Virus ◽  
Different Types ◽  
Complex Glycans ◽  
Ion Collision

AbstractNegative ion collision-induced dissociation (CID) of underivatized N-glycans has proved to be a simple, yet powerful method for their structural determination. Recently, we have identified a series of such structures with GalNAc rather than the more common galactose capping the antennae of hybrid and complex glycans. As part of a series of publications describing the negative ion fragmentation of different types of N-glycan, this paper describes their CID spectra and estimated nitrogen cross sections recorded by travelling wave ion mobility mass spectrometry (TWIMS). Most of the glycans were derived from the recombinant glycoproteins gp120 and gp41 from the human immunodeficiency virus (HIV), recombinantly derived from human embryonic kidney (HEK 293T) cells. Twenty-six GalNAc-capped hybrid and complex N-glycans were identified by a combination of TWIMS, negative ion CID, and exoglycosidase digestions. They were present as the neutral glycans and their sulfated and α2→3-linked sialylated analogues. Overall, negative ion fragmentation of glycans generates fingerprints that reveal their structural identity.

scholarly journals Rapid determination of N-methylpyrrolidine in cefepime by combining direct infusion electrospray ionisation-time-of-flight mass spectrometry with field asymmetric waveform ion mobility spectrometry

2015 ◽  
Vol 7 (1) ◽  
pp. 34-39 ◽  
Author(s):  
Robert W. Smith ◽  
Lisa B. Cox ◽  
Aswandi Yudin ◽  
James C. Reynolds ◽  
Mark Powell ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Rapid Determination ◽  
Time Of Flight ◽  
Asymmetric Waveform ◽  
Direct Infusion ◽  
Electrospray Ionisation ◽  
Flight Mass Spectrometry

FAIMS separation prior to mass spectrometry enables selective transmission of NMP in cefepime without interference from NMP formed by in-source CID.

scholarly journals Amphitrite: A program for processing travelling wave ion mobility mass spectrometry data

2013 ◽  
Vol 345-347 ◽  
pp. 54-62 ◽  
Author(s):  
Ganesh N. Sivalingam ◽  
Jun Yan ◽  
Harpal Sahota ◽  
Konstantinos Thalassinos
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Travelling Wave ◽  
Mass Spectrometry Data ◽  
Ion Mobility Mass Spectrometry

scholarly journals Online Parallel Accumulation–Serial Fragmentation (PASEF) with a Novel Trapped Ion Mobility Mass Spectrometer

2018 ◽  
Vol 17 (12) ◽  
pp. 2534-2545 ◽  
Author(s):  
Florian Meier ◽  
Andreas-David Brunner ◽  
Scarlet Koch ◽  
Heiner Koch ◽  
Markus Lubeck ◽  
...  
Keyword(s):  
Mass Spectrometer ◽  
Ion Mobility ◽  
Trapped Ion
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