Direct characterization of intact polypeptides by matrix-assisted laser desorption electrospray ionization quadrupole Fourier transform ion cyclotron resonance mass spectrometry

2007 ◽  
Vol 21 (7) ◽  
pp. 1150-1154 ◽  
Author(s):  
Jason S. Sampson ◽  
Adam M. Hawkridge ◽  
David C. Muddiman
Keyword(s):  
Mass Spectrometry ◽  
Fourier Transform ◽  
Electrospray Ionization ◽  
Cyclotron Resonance ◽  
Desorption Electrospray Ionization ◽  
Laser Desorption ◽  
Ion Cyclotron Resonance ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

scholarly journals Matrix-assisted laser desorption ionization and electrospray ionization combined with Fourier transform ion cyclotron resonance mass spectrometry

1997 ◽  
Vol 13 (2) ◽  
pp. 145-150 ◽  
Author(s):  
Paul O. Staneke ◽  
Nico M. M. Nibbering
Keyword(s):  
Mass Spectrometry ◽  
Fourier Transform ◽  
Electrospray Ionization ◽  
Cyclotron Resonance ◽  
Laser Desorption ◽  
Ion Cyclotron Resonance ◽  
Laser Desorption Ionization ◽  
Desorption Ionization ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

During recent years, matrix-assisted laser desorption ionization (MALDI) and electrospray ionization (ESI) are successfully employed to analyze biomolecules and polymers. In combination with Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry, high mass resolution and mass measurement accuracy can be achieved to enable the determination of molecular weights and structural characterization of biochemical compounds larger than 10 kDa.

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