Ion fragmentation in an electrospray ionization mass spectrometer interface with different gases

2001 ◽  
Vol 15 (4) ◽  
pp. 249-257 ◽  
Author(s):  
Bradley B. Schneider ◽  
D. J. Douglas ◽  
David D. Y. Chen
Keyword(s):  
Electrospray Ionization ◽  
Mass Spectrometer ◽  
Ionization Mass ◽  
Ion Fragmentation ◽  
Different Gases

scholarly journals Observation of charged droplets from electrospray ionization (ESI) plumes in API mass spectrometers

2021 ◽  
Author(s):  
Clara Markert ◽  
Marco Thinius ◽  
Laura Lehmann ◽  
Chris Heintz ◽  
Florian Stappert ◽  
...  
Keyword(s):  
Electrospray Ionization ◽  
Mass Spectrometer ◽  
Strong Electric Field ◽  
Ion Source ◽  
Mass Analyzer ◽  
Ionization Mass ◽  
Inlet System ◽  
Mass Spectrometers ◽  
Charged Droplets ◽  
Pass Through

AbstractElectrospray ionization (ESI) generates bare analyte ions from charged droplets, which result from spraying a liquid in a strong electric field. Experimental observations available in the literature suggest that at least a significant fraction of the initially generated droplets remain large, have long lifetimes, and can thus aspirate into the inlet system of an atmospheric pressure ionization mass spectrometer (API-MS). We report on the observation of fragment signatures from charged droplets penetrating deeply the vacuum stages of three commercial mass spectrometer systems with largely different ion source and spray configurations. Charged droplets can pass through the ion source and pressure reduction stages and even into the mass analyzer region. Since droplet signatures were found in all investigated instruments, the incorporation of charged droplets is considered a general phenomenon occurring with common spray conditions in ESI sources.

scholarly journals Constraining the response factors of an extractive electrospray ionization mass spectrometer for near-molecular aerosol speciation

2021 ◽  
Vol 14 (11) ◽  
pp. 6955-6972
Author(s):  
Dongyu S. Wang ◽  
Chuan Ping Lee ◽  
Jordan E. Krechmer ◽  
Francesca Majluf ◽  
Yandong Tong ◽  
...  
Keyword(s):  
Electrospray Ionization ◽  
Mass Spectrometer ◽  
Molecular Level ◽  
Ionization Mass ◽  
Molecular Response ◽  
Response Factor ◽  
Particle Phase ◽  
Aerosol Composition ◽  
Response Factors ◽  
Wide Range

Abstract. Online characterization of aerosol composition at the near-molecular level is key to understanding chemical reaction mechanisms, kinetics, and sources under various atmospheric conditions. The recently developed extractive electrospray ionization time-of-flight mass spectrometer (EESI-TOF) is capable of detecting a wide range of organic oxidation products in the particle phase in real time with minimal fragmentation. Quantification can sometimes be hindered by a lack of available commercial standards for aerosol constituents, however. Good correlations between the EESI-TOF and other aerosol speciation techniques have been reported, though no attempts have yet been made to parameterize the EESI-TOF response factor for different chemical species. Here, we report the first parameterization of the EESI-TOF response factor for secondary organic aerosol (SOA) at the near-molecular level based on its elemental composition. SOA was formed by ozonolysis of monoterpene or OH oxidation of aromatics inside an oxidation flow reactor (OFR) using ammonium nitrate as seed particles. A Vocus proton-transfer reaction mass spectrometer (Vocus-PTR) and a high-resolution aerosol mass spectrometer (AMS) were used to determine the gas-phase molecular composition and the particle-phase bulk chemical composition, respectively. The EESI response factors towards bulk SOA coating and the inorganic seed particle core were constrained by intercomparison with the AMS. The highest bulk EESI response factor was observed for SOA produced from 1,3,5-trimethylbenzene, followed by those produced from d-limonene and o-cresol, consistent with previous findings. The near-molecular EESI response factors were derived from intercomparisons with Vocus-PTR measurements and were found to vary from 103 to 106 ion counts s−1 ppb−1, mostly within ±1 order of magnitude of their geometric mean of 104.6 ion counts s−1 ppb−1. For aromatic SOA components, the EESI response factors correlated with molecular weight and oxygen content and inversely correlated with volatility. The near-molecular response factors mostly agreed within a factor of 20 for isomers observed across the aromatics and biogenic systems. Parameterization of the near-molecular response factors based on the measured elemental formulae could reproduce the empirically determined response factor for a single volatile organic compound (VOC) system to within a factor of 5 for the configuration of our mass spectrometers. The results demonstrate that standard-free quantification using the EESI-TOF is possible.

scholarly journals Direct coupling of a free-flow isotachophoresis (FFITP) device with electrospray ionization mass spectrometry (ESI-MS)

Lab on a Chip ◽  
2015 ◽  
Vol 15 (17) ◽  
pp. 3495-3502 ◽  
Author(s):  
J. K. Park ◽  
C. D. M Campos ◽  
P. Neužil ◽  
L. Abelmann ◽  
R. M. Guijt ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Sample Preparation ◽  
Electrospray Ionization ◽  
Mass Spectrometer ◽  
Electrospray Ionization Mass Spectrometry ◽  
Direct Coupling ◽  
Free Flow ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Esi Ms

The direct coupling of free-flow isotachophoresis device with an electrospray-ionization-mass-spectrometer allows continuous online detection without any sample preparation such as purification and labeling.

An electrospray-ionization mass spectrometer with new features

1990 ◽  
Vol 4 (3) ◽  
pp. 81-87 ◽  
Author(s):  
Swapan K. Chowdhury ◽  
Viswanatham Katta ◽  
Brian T. Chait
Keyword(s):  
Electrospray Ionization ◽  
Mass Spectrometer ◽  
Ionization Mass
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