Gas phase unimolecular 1,1-hydrogen elimination: Reaction mechanism and isotope effect

1984 ◽  
Vol 26 (5) ◽  
pp. 621-636 ◽  
Author(s):  
Vincenzo Barone ◽  
Nadia Bianchi ◽  
Francesco Lelj ◽  
Nino Russo
Keyword(s):  
Reaction Mechanism ◽  
Gas Phase ◽  
Isotope Effect ◽  
Elimination Reaction ◽  
Hydrogen Elimination

Methanolysis of 1-aryl-1,2-epoxycyclohexanes in the condensed and in the gas phase: importance of the substituent for the reaction mechanism

2005 ◽  
Vol 18 (4) ◽  
pp. 321-328 ◽  
Author(s):  
Paolo Crotti ◽  
Valeria Di Bussolo ◽  
Franco Macchia ◽  
Lucilla Favero ◽  
Mauro Pineschi ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Gas Phase

Gas-phase Reaction Mechanism of Allyl anion with N2O

2007 ◽  
Vol 23 (02) ◽  
pp. 217-222
Author(s):  
LIU Le-Yan ◽  
◽  
◽  
GENG Zhi-Yuan ◽  
ZHAO Cun-Yuan ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Gas Phase ◽  
Phase Reaction ◽  
Gas Phase Reaction

DFT Study of deNOxReactions in the Gas Phase: Mimicking the Reaction Mechanism over BaNaY Zeolites

2009 ◽  
Vol 113 (24) ◽  
pp. 6730-6739 ◽  
Author(s):  
Chun-Yi Sung ◽  
Randall Q. Snurr ◽  
Linda J. Broadbelt
Keyword(s):  
Reaction Mechanism ◽  
Gas Phase ◽  
Dft Study

scholarly journals Structural evidence for the covalent modification of FabH by 4,5-dichloro-1,2-dithiol-3-one (HR45)

2017 ◽  
Vol 15 (30) ◽  
pp. 6310-6313 ◽  
Author(s):  
Alexander G. Ekström ◽  
Van Kelly ◽  
Jon Marles-Wright ◽  
Scott L. Cockroft ◽  
Dominic J. Campopiano
Keyword(s):  
Mass Spectrometry ◽  
Reaction Mechanism ◽  
Active Site ◽  
Covalent Modification ◽  
Elimination Reaction ◽  
Covalent Adduct ◽  
Michael Type Addition

Mass spectrometry and modelling shows the antimicrobial inhibitor 4,5-dichloro-1,2-dithiol-3-one (HR45) acts by forming a covalent adduct with the target β-ketoacyl-ACP synthase III (FabH). The 5-chloro substituent directs attack of the essential active site thiol (C112) via a Michael type addition elimination reaction mechanism.

scholarly journals The HNO− radical anion: A proposed intermediate in diazeniumdiolate synthesis using nitric oxide and alkoxides

2018 ◽  
Vol 25 (1) ◽  
pp. 82-85 ◽  
Author(s):  
Zhe-Chen Wang ◽  
Ya-Ke Li ◽  
Sheng-Gui He ◽  
Veronica M Bierbaum
Keyword(s):  
Nitric Oxide ◽  
Reaction Mechanism ◽  
Gas Phase ◽  
Radical Anion ◽  
Room Temperature ◽  
Hydrogen Transfer ◽  
Gas Phase Reactions ◽  
Ionic Product

The strategy of synthesizing diazeniumdiolates (X–N(O)=NO−) through the coexistence of nitric oxide and alkoxides (RO−) was introduced by Wilhelm Traube 120 years ago. Today, despite the wide use of diazeniumdiolate derivatives to release nitric oxide in the treatment of cancer, the first step of the reaction mechanism for diazeniumdiolate synthesis remains a mystery and is thought to be complex. We have studied the gas-phase reactions of nitric oxide with alkoxides at room temperature. An electron-coupled hydrogen transfer is observed, and the radical anion HNO− is the only ionic product in these reactions. HNO− can further react with nitric oxide to form N2O and HO−.

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