Topological indices and QSPR modeling of some novel drugs used in the cancer treatment

2021 ◽  
Author(s):  
Özge Çolakoğlu Havare
Keyword(s):  
Cancer Treatment ◽  
Topological Indices ◽  
Novel Drugs ◽  
Qspr Modeling

Apoptotic Pathway

2021 ◽  
pp. 290-311
Author(s):  
Durdana Yasin ◽  
Md Zafaryab ◽  
Khalid Umar Fakhri ◽  
Shaheen Husain ◽  
Bushra Afzal ◽  
...  
Keyword(s):  
Natural Products ◽  
Cancer Treatment ◽  
Tissue Homeostasis ◽  
The Novel ◽  
Down Regulation ◽  
Apoptotic Pathway ◽  
Biochemical Characteristics ◽  
Novel Drugs ◽  
Natural Mechanism ◽  
Apoptotic Factors

Cancer is a major killer disease caused by uncontrolled growth and invasion of cells. Apoptosis is the cell's natural mechanism of death, which maintains tissue homeostasis. Any mutation that disturbs the apoptotic pathway leads to deregulated proliferation, resistance, and evasion of apoptosis. This evasion is one of the hallmarks of malignant developments. Apoptosis takes place via two distinct pathways i.e. the intrinsic and the extrinsic pathways. These pathways use cleaved caspases to execute apoptosis which in turn cleave many downstream proteins to kill the cells. They can also be inhibited through various means that include up-regulation of anti-apoptotic and down-regulation of pro-apoptotic factors. The authors here aim to impart a comprehensive understanding of the biochemical characteristics of these pathways that render scientists target these pathways and assess apoptosis restoring abilities of the novel drugs and natural products for cancer treatment.

1077: A Novel Apoptosis-Inducing Gene and its Application in Prostate Cancer Treatment

2004 ◽  
Vol 171 (4S) ◽  
pp. 284-284
Author(s):  
Yi Lu ◽  
Jun Zhang ◽  
Ben Beheshti ◽  
Ximing J. Yang ◽  
Syamal K. Bhattacharya ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Treatment ◽  
Prostate Cancer Treatment

Novel Drugs Highly Effective in Resistant HIV

2007 ◽  
Vol 38 (4) ◽  
pp. 9
Author(s):  
TIMOTHY F. KIRN
Keyword(s):  
Novel Drugs ◽  
Highly Effective

Molecular Mechanism of Apoptosis Induction by Resveratrol, a Natural Cancer Chemopreventive Agent

2008 ◽  
Vol 78 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Fan ◽  
Jiang ◽  
Zhang ◽  
Bai
Keyword(s):  
Cancer Treatment ◽  
Molecular Mechanism ◽  
Apoptosis Induction ◽  
Protective Agents ◽  
Chemopreventive Agent ◽  
Naturally Occurring ◽  
Apoptosis Pathways ◽  
Present Understanding

In efforts to identify naturally occurring compounds that act as protective agents, resveratrol, a phytoalexin existing in wine, has attracted much interest because of its diverse pharmacological characteristics. Considering that apoptosis induction is the most potent defense approach for cancer treatment, we have tried to summarize our present understanding of apoptosis induction by resveratrol based on the two major apoptosis pathways.

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