On the molecular origin of the sensitivity to impact of cyclic nitramines

2018 ◽  
Vol 119 (8) ◽  
pp. e25868 ◽  
Author(s):  
Marco A. S. Oliveira ◽  
Itamar Borges
Keyword(s):  
Molecular Origin ◽  
Cyclic Nitramines

Purines and Pyrimidines: Metabolism, Function and Potential as therapeutic options in neurodegenerative diseases

2020 ◽  
Vol 21 ◽  
Author(s):  
Debanjan Kundu ◽  
Vikash Kumar Dubey
Keyword(s):  
Neurodegenerative Diseases ◽  
Neurodegenerative Disorders ◽  
Protein Misfolding ◽  
Molecular Mechanisms ◽  
Treatment Regimens ◽  
Loss Of Balance ◽  
Current Scenario ◽  
Unexplored Area ◽  
Molecular Origin ◽  
Purines And Pyrimidines

Abstract:: Various neurodegenerative disorders have molecular origin but some common molecular mechanisms. In the current scenario, there are very few treatment regimens present for advanced neurodegenerative diseases. In this context, there is an urgent need for alternate options in the form of natural compounds with an ameliorating effect on patients. There have been individual scattered experiments trying to identify potential values of various intracellular metabolites. Purines and Pyrimidines, which are vital molecules governing various aspects of cellular biochemical reactions, have been long sought as crucial candidates for the same, but there are still many questions that go unanswered. Some critical functions of these molecules associated with neuromodulation activities have been identified. They are also known to play a role in foetal neurodevelopment, but there is a lacuna in understanding their mechanisms. In this review, we have tried to assemble and identify the importance of purines and pyrimidines, connecting them with the prevalence of neurodegenerative diseases. The leading cause of this class of diseases is protein misfolding and the formation of amyloids. A direct correlation between loss of balance in cellular homeostasis and amyloidosis is yet an unexplored area. This review aims at bringing the current literature available under one umbrella serving as a foundation for further extensive research in this field of drug development in neurodegenerative diseases.

scholarly journals Molecular origin of viscoelasticity in mineralized collagen fibrils

2021 ◽  
Author(s):  
Mario Milazzo ◽  
Alessio David ◽  
Gang Seob Jung ◽  
Serena Danti ◽  
Markus J. Buehler
Keyword(s):  
Collagen Fibrils ◽  
Skeletal System ◽  
Mineralized Tissue ◽  
Molecular Origin ◽  
Mineralized Collagen

Bone is mineralized tissue constituting the skeletal system, supporting and protecting body organs and tissues. In addition to such fundamental mechanical functions, bone also plays a remarkable role in sound...

Perspectives on Astringency Sensation: An Alternative Hypothesis on the Molecular Origin of Astringency

2021 ◽  
Author(s):  
Francis Canon ◽  
Christine Belloir ◽  
Eric Bourillot ◽  
Hélène Brignot ◽  
Loïc Briand ◽  
...  
Keyword(s):  
Alternative Hypothesis ◽  
Molecular Origin

scholarly journals Time-dependent communication between multiple amino acids during protein folding

2021 ◽  
Vol 12 (16) ◽  
pp. 5944-5951
Author(s):  
Song-Ho Chong ◽  
Sihyun Ham
Keyword(s):  
Amino Acids ◽  
Protein Folding ◽  
Transition State ◽  
Time Dependent ◽  
Transition Path ◽  
Contact Formation ◽  
Molecular Origin

Cooperativity in contact formation among multiple amino acids starts to develop upon entering the folding transition path and attains a maximum at the folding transition state, providing the molecular origin of the two-state folding behavior.

scholarly journals Two out of the 11 genes of an unusual human G6P[6] rotavirus isolate are of bovine origin

2008 ◽  
Vol 89 (10) ◽  
pp. 2630-2635 ◽  
Author(s):  
Jelle Matthijnssens ◽  
Mustafizur Rahman ◽  
Marc Van Ranst
Keyword(s):  
Complete Genome ◽  
Bovine Rotavirus ◽  
Rotavirus Vaccines ◽  
Human Rotavirus ◽  
New Gene ◽  
Molecular Origin ◽  
Encoding Gene ◽  
Vp7 Gene

In 2003, we described the first human G6P[6] rotavirus strain (B1711). To investigate further the molecular origin of this strain and to determine the possible reassortments leading to this new gene constellation, the complete genome of strain B1711 was sequenced. SimPlot analyses were conducted to compare strain B1711 with other known rotavirus gene segments, and phylogenetic dendrograms were constructed to analyse the origin of the eleven genome segments of strain B1711. Our analysis indicated that strain B1711 acquired its VP1-, VP2-, VP4-, VP6- and NSP1–5-encoding gene segments from human DS-1-like P[6] rotavirus strains, and its VP3 and VP7 gene segments from a bovine rotavirus strain through reassortment. The introduction of animal–human reassortant strains, which might arise in either of the hosts, into the human rotavirus population is an important mechanism for the generation of rotavirus diversity, and might be a challenge for the current rotavirus vaccines and vaccines under development.

scholarly journals Molecular Origin of Blood‐Based Infrared Spectroscopic Fingerprints

2021 ◽  
Author(s):  
Liudmila Voronina ◽  
Cristina Leonardo ◽  
Johannes B. Mueller‐Reif ◽  
Philipp E. Geyer ◽  
Marinus Huber ◽  
...  
Keyword(s):  
Infrared Spectroscopic ◽  
Molecular Origin
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