Molecular level understanding of the role of aldehyde in vegetable-aldehyde-collagen cross-linking reaction

2011 ◽  
Vol 112 (16) ◽  
pp. 2832-2839 ◽  
Author(s):  
Shang-Zhi Pu ◽  
Ya-Nan Wang ◽  
Qiang He ◽  
Xue-Pin Liao ◽  
Wen-Hua Zhang ◽  
...  
Keyword(s):  
Molecular Level ◽  
Cross Linking ◽  
Collagen Cross Linking

scholarly journals Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Marwa Kamel ◽  
Mohamed Wagih ◽  
Gokhan S. Kilic ◽  
Concepcion R. Diaz-Arrastia ◽  
Mohamed A. Baraka ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Treatment Options ◽  
Uterine Fibroids ◽  
Cross Linking ◽  
Ki 67 ◽  
Subsequent Formation ◽  
Lysyl Oxidases ◽  
Cross Links ◽  
Collagen Cross Linking

The role of the extracellular matrix (ECM) in uterine fibroids (UF) has recently been appreciated. Overhydroxylation of lysine residues and the subsequent formation of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) cross-links underlie the ECM stiffness and profoundly affect tumor progression. The aim of the current study was to investigate the relationship between ECM of UF, collagen and collagen cross-linking enzymes [lysyl hydroxylases (LH) and lysyl oxidases (LOX)], and the development and progression of UF. Our results indicated that hydroxyl lysine (Hyl) and HP cross-links are significantly higher in UF compared to the normal myometrial tissues accompanied by increased expression of LH (LH2b) and LOX. Also, increased resistance to matrix metalloproteinases (MMP) proteolytic degradation activity was observed. Furthermore, the extent of collagen cross-links was positively correlated with the expression of myofibroblast marker (α-SMA), growth-promoting markers (PCNA; pERK1/2;FAKpY397; Ki-67; and Cyclin D1), and the size of UF. In conclusion, our study defines the role of overhydroxylation of collagen and collagen cross-linking enzymes in modulating UF cell proliferation, differentiation, and resistance to MMP. These effects can establish microenvironment conducive for UF progression and thus represent potential target treatment options of UF.

Failure of mineralized collagen fibrils: Modeling the role of collagen cross-linking

2008 ◽  
Vol 41 (7) ◽  
pp. 1427-1435 ◽  
Author(s):  
Thomas Siegmund ◽  
Matthew R. Allen ◽  
David B. Burr
Keyword(s):  
Collagen Fibrils ◽  
Cross Linking ◽  
Collagen Cross Linking ◽  
Mineralized Collagen

scholarly journals ROLE OF CORNEAL COLLAGEN CROSS LINKING IN KERATOCONUS

2015 ◽  
Vol 4 (73) ◽  
pp. 12760-12774
Author(s):  
Atul Gupta ◽  
Superna M ◽  
Bhimasankar D ◽  
Vijayleela M
Keyword(s):  
Cross Linking ◽  
Collagen Cross Linking ◽  
Corneal Collagen

scholarly journals The Role of Nonenzymatic Glycation and Carbonyls in Collagen Cross-Linking for the Treatment of Keratoconus

2011 ◽  
Vol 52 (9) ◽  
pp. 6363 ◽  
Author(s):  
Gage Brummer ◽  
Stacy Littlechild ◽  
Scott McCall ◽  
Yuntao Zhang ◽  
Gary W. Conrad
Keyword(s):  
Cross Linking ◽  
Nonenzymatic Glycation ◽  
Collagen Cross Linking

Role of collagen cross-linking on equine wound contraction and healing

2008 ◽  
Vol 18 (3) ◽  
pp. 239-247 ◽  
Author(s):  
Kamran Sardari ◽  
Hossein Kazemi ◽  
Mohamad Reza Emami ◽  
Ahmad Reza Movasaghi ◽  
Amir Afkhami Goli
Keyword(s):  
Wound Contraction ◽  
Cross Linking ◽  
Collagen Cross Linking

Role of collagen cross linking in keratoconus

2017 ◽  
Vol 5 (1) ◽  
pp. 6
Author(s):  
PV Nanda Kumar Reddy ◽  
BV Kranthi
Keyword(s):  
Cross Linking ◽  
Collagen Cross Linking

Role of Copper in Collagen Cross-linking and Its Influence on Selected Mechanical Properties of Chick Bone and Tendon

1982 ◽  
Vol 112 (4) ◽  
pp. 708-716 ◽  
Author(s):  
William Opsahl ◽  
Haig Zeronian ◽  
Mike Ellison ◽  
Davis Lewis ◽  
Robert B. Rucker ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Cross Linking ◽  
Collagen Cross Linking

Role of Corneal Collagen Cross-Linking in Pseudophakic Bullous Keratopathy

Ophthalmology ◽  
2013 ◽  
Vol 120 (12) ◽  
pp. 2413-2418 ◽  
Author(s):  
Ritu Arora ◽  
Aditi Manudhane ◽  
Ravindra Kumar Saran ◽  
Jawaharlal Goyal ◽  
Gaurav Goyal ◽  
...  
Keyword(s):  
Cross Linking ◽  
Bullous Keratopathy ◽  
Pseudophakic Bullous Keratopathy ◽  
Collagen Cross Linking ◽  
Corneal Collagen
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