Theoretical mechanisms of the superoxide radical anion catalyzed by the copper-zinc superoxide dismutase

2009 ◽  
Vol 110 (7) ◽  
pp. 1394-1401 ◽  
Author(s):  
Dezhan Chen ◽  
Qingli Wang ◽  
Honghong Zhang ◽  
Shizhen Mi ◽  
Juliang Wang ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Radical Anion ◽  
Superoxide Radical ◽  
Superoxide Radical Anion ◽  
Copper Zinc Superoxide Dismutase ◽  
Zinc Superoxide Dismutase ◽  
Copper Zinc

scholarly journals Exogenous Superoxide Dismutase: Action on Liver Oxidative Stress in Animals with Streptozotocin-Induced Diabetes

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Fábio Cangeri Di Naso ◽  
Alexandre Simões Dias ◽  
Marilene Porawski ◽  
Norma Anair Possa Marroni
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Superoxide Radical ◽  
Inos Expression ◽  
Copper Zinc Superoxide Dismutase ◽  
Zinc Superoxide Dismutase ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Streptozotocin Induced Diabetes ◽  
Copper Zinc

Aim. To investigate the effects of exogenous antioxidant copper zinc superoxide dismutase (Cu/Zn SOD) on oxidative stress in the experimental model of diabetes mellitus (DM).Methods. Twenty eight male Wistar rats divided in four groups were used: control (CO), controls treated with SOD (CO + SOD), diabetics (DM), and diabetics treated with SOD (DM + SOD). SOD (orgotein, 13 mg/Kg body weight was administered. DM was induced by a single streptozotocin injection (i.p., 70 mg/kg), and 60 days later, we evaluated liver oxidative stress.Results. Liver lipoperoxidation was increased in the DM group and significantly decreased in the DM + SOD group. Nitrite and nitrate measures were reduced in the DM and increased in the DM + SOD group, while iNOS expression in the DM group was 32% greater than in the CO and 53% greater in the DM + SOD group than in the DM group (P<.01). P65 expression was 37% higher in the DM (P<.05), and there was no significant difference between the DM and DM + SOD groups.Conclusion. SOD treatment reduced liver oxidative stress in diabetic animals, even though it did not change NFκB. SOD also increased NO, probably by the increased dismutation of the superoxide radical. The iNOS expression increase, which became even more evident after SOD administration.

Effect of Copper-Zinc Superoxide Dismutase on Endothelium-Dependent Vasodilation in Patients With Essential Hypertension

Hypertension ◽  
1995 ◽  
Vol 26 (6) ◽  
pp. 863-868 ◽  
Author(s):  
Carlos E. García ◽  
Crescence M. Kilcoyne ◽  
Carmine Cardillo ◽  
Richard O. Cannon ◽  
Arshed A. Quyyumi ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Essential Hypertension ◽  
Copper Zinc Superoxide Dismutase ◽  
Zinc Superoxide Dismutase ◽  
Copper Zinc ◽  
Effect Of Copper

Localization of copper-zinc superoxide dismutase mRNA in human hippocampus by in situ hybridization

1989 ◽  
Vol 105 (1-2) ◽  
pp. 41-46 ◽  
Author(s):  
Irène Ceballos ◽  
France Javoy-Agid ◽  
Etienne C. Hirsch ◽  
Sylvie Dumas ◽  
Pierre P. Kamoun ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
In Situ Hybridization ◽  
Copper Zinc Superoxide Dismutase ◽  
Zinc Superoxide Dismutase ◽  
Human Hippocampus ◽  
Copper Zinc
Sign in / Sign up

Export Citation Format

Share Document