Dock around the Clock – Current Status of Small Molecule Docking and Scoring

2006 ◽  
Vol 25 (7) ◽  
pp. 605-615 ◽  
Author(s):  
Ulrich Rester
Keyword(s):  
Small Molecule ◽  
Current Status ◽  
Docking And Scoring ◽  
Molecule Docking

scholarly journals Bioanalysis of small-molecule drugs in nasal and paranasal tissues and secretions: Current status and perspectives

2012 ◽  
Vol 10 (3) ◽  
pp. 686-702
Author(s):  
Ana Serralheiro ◽  
Gilberto Alves ◽  
Amílcar Falcão
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Small Molecule ◽  
Intranasal Administration ◽  
Quantitative Measurement ◽  
Current Status ◽  
Small Molecule Drugs ◽  
Development And Validation ◽  
Liquid Chromatographic

AbstractOver the last years, interest in intranasal administration as an alternative and promising route for the delivery of drugs withlocal, systemic, and even central nervous system action has tremendously increased. Accordingly, understanding of the propertiesand characteristics of the nasal cavity as well as the biodisposition processes of drugs into the nasal compartments is acquiringa significant prominence in the field of pharmacology. In this context, the development and validation of bioanalytical methodologies for the quantitative measurement of drugs and their metabolites in nasal and paranasal tissues and/or secretions is of the utmostimportance. However, currently, information concerning bioanalysis of drugs in nasal and paranasal tissues and/or secretionsis scattered. This review aims to provide a valuable overview of the methodologies that have been used for the collectionand preparation of nasal and paranasal samples with special emphasis placed on the review of liquid chromatographic methodsemployed for the quantitative determination of small-molecule drugs and their metabolites in such specimens.

scholarly journals Tailoring the specificity of the type C feruloyl esterase FoFaeC from Fusarium oxysporum towards methyl sinapate by rational redesign based on small molecule docking simulations

PLoS ONE ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. e0198127 ◽  
Author(s):  
Io Antonopoulou ◽  
Cameron Hunt ◽  
Gabriella Cerullo ◽  
Simona Varriale ◽  
Alexandra Gerogianni ◽  
...  
Keyword(s):  
Fusarium Oxysporum ◽  
Small Molecule ◽  
Feruloyl Esterase ◽  
Docking Simulations ◽  
Type C ◽  
Molecule Docking

Correction to On the Applicability of Elastic Network Normal Modes in Small-Molecule Docking

2014 ◽  
Vol 54 (12) ◽  
pp. 3453-3453 ◽  
Author(s):  
Matthias Dietzen ◽  
Elena Zotenko ◽  
Andreas Hildebrandt ◽  
Thomas Lengauer
Keyword(s):  
Small Molecule ◽  
Normal Modes ◽  
Elastic Network ◽  
Molecule Docking

scholarly journals Nucleic Acid Drugs—Current Status, Issues, and Expectations for Exosomes

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 5002
Author(s):  
Yoji Yamada
Keyword(s):  
Nucleic Acid ◽  
Small Molecule ◽  
Viral Infections ◽  
Genetic Disorders ◽  
Clinical Status ◽  
Lipid Nanoparticles ◽  
Current Status ◽  
Nucleic Acid Therapeutics ◽  
Therapeutic Modalities ◽  
Novel Therapeutic

Nucleic acid drugs are being developed as novel therapeutic modalities. They have great potential to treat human diseases such as cancers, viral infections, and genetic disorders due to unique characteristics that make it possible to approach undruggable targets using classical small molecule or protein/antibody-based biologics. In this review, I describe the advantages, classification, and clinical status of nucleic acid therapeutics. To date, more than 10 products have been launched, and many products have been tested in clinics. To promote the use of nucleic acid therapeutics such as antibodies, several hurdles need to be surmounted. The most important issue is the delivery of nucleic acids and several other challenges have been reported. Recent advanced delivery platforms are lipid nanoparticles and ligand conjugation approaches. With the progress of exosome biology, exosomes are expected to contribute to the solution of various problems associated with nucleic acid drugs.

scholarly journals Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors—The Current Status

2020 ◽  
Vol 11 ◽  
Author(s):  
Narasimha M. Beeraka ◽  
Surya P. Sadhu ◽  
SubbaRao V. Madhunapantula ◽  
Rajeswara Rao Pragada ◽  
Andrey A. Svistunov ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Current Status
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