Use of structural alerts to develop rules for identifying chemical substances with skin irritation or skin corrosion potential

2005 ◽  
Vol 24 (3) ◽  
pp. 332-342 ◽  
Author(s):  
Etje Hulzebos ◽  
John D. Walker ◽  
Ingrid Gerner ◽  
Kerstin Schlegel
Keyword(s):  
Corrosion Potential ◽  
Skin Irritation ◽  
Chemical Substances ◽  
Structural Alerts

Ex Vivo Human Skin: An Alternative Test System for Skin Irritation and Corrosion Assays

2021 ◽  
pp. 026119292110386
Author(s):  
Samara Eberlin ◽  
Gustavo Facchini ◽  
Gustavo Henrique da Silva ◽  
Samir Eberlin ◽  
Aline Rodrigues Bragatto ◽  
...  
Keyword(s):  
Human Skin ◽  
Corrosion Potential ◽  
Ex Vivo ◽  
Skin Irritation ◽  
Test System ◽  
Culture Conditions ◽  
Promising Tool ◽  
Alternative Test ◽  
Specific Culture ◽  
Skin Biology

Native human skin has been reported in the literature as being an important experimental model for studying skin biology. Studies performed by our group have shown that ex vivo skin, from elective plastic surgery, maintains the biological characteristics of native skin under specific culture conditions. As such, it might be a feasible model for the safety and efficacy testing of topical substances. While Brazil is at the forefront of global regulation implementation, Brazilian researchers are not always able to transfer certain widely used protocols to their laboratories, particularly protocols that involve the use of reconstructed tissues with limited viability, such as those for skin corrosion (OECD TG 431) and irritation testing (OECD TG 439). In this study, we investigated the applicability of the ex vivo skin model to the evaluation of irritation and corrosion potential of a number of proficiency substances described in TG 431 and TG 439. The skin fragments were standardised in size and diameter, and placed into cell culture inserts. The experimental protocol was conducted according to TG 431 and TG 439. The results obtained show that ex vivo skin could represent a promising tool for the evaluation of irritation and corrosion potential of substances (subject to inclusion and exclusion criteria), as recommended by OECD guidelines. While this is a proof-of-concept study, the use of ex vivo skin should be considered for such testing.

Evaluation of anti-pyretic activity of Dracaena sanderiana by Brewer’s yeast method

2020 ◽  
Vol 9 (2) ◽  
pp. 32-34
Author(s):  
Pavani C H
Keyword(s):  
Herbal Remedies ◽  
Standard Drug ◽  
Chemical Substances ◽  
Beneficial Effects ◽  
Potential Value ◽  
Plant Effects ◽  
Therapeutic Properties ◽  
Dracaena Sanderiana ◽  
Anti Inflammatory ◽  
Inflammatory Action

These medicinal plants are used to develop a therapy for the disease. To improve the science, investigate the scientific proof and activities validation, therefore the use of various herbal remedies for their pain-relieving and anti-inflammatory action in these current days. includes influence, anti-inflammatory, anti effect, analgesia, effects and some beneficial effects on the GI system. show the potential value of pain relief, cancer prevention and weight loss. According to these plant effects, consider that this present study was mainly based on to investigate and likely to reduce the fever caused by the outdoor and indoor. potential of is evidenced in leave studies. The medicinal plant produces a variety of chemical substances which shows significant therapeutic properties with the standard drug paracetamol.

Investigations of the corrosion activity of the KAlCl4 melts by the methods of physicochemical analysis

2019 ◽  
Vol 24 (4) ◽  
pp. 59-66
Author(s):  
E.S. Filatov
Keyword(s):  
Water Vapor ◽  
Hydrochloric Acid ◽  
Input Data ◽  
Corrosion Potential ◽  
Physicochemical Analysis ◽  
Metal Alloys ◽  
Corrosion Activity ◽  
Protection Efficiency ◽  
Gas Atmosphere ◽  
Metal Aluminum

Corrosion behavior of metal alloys in a melt of potassium chloroaluminate (KAlCl4) was investigated. Metal aluminum was used as a protector for protection against continuous frontal corrosion. The equilibrium potentials of aluminum and the corrosion potential of the alloys were measured. The data were obtained to evaluate the corrosion ability of the system of molten salt of potassium chloroaluminate - gas (argon) by measuring the redox potential of the specified environment depending on the composition of the gas atmosphere above it, i.e. from impurities of water vapor, hydrochloric acid, oxygen and other, for example, carbonaceous gases. The calculations of the protection efficiency using the potential difference between the metal aluminum and the protected material were performed. The regularities of changes in the equilibrium potentials of aluminum from the temperature and concentration were established as the fundamental data for possible use at determining the composition ratio of potassium chlorides and aluminum in potassium chloroaluminate as input data for the development of a sensor of composition of chloroaluminate potassium.

A study on the variation of chemical substances in flue-cured tobaccos with different oil proportions

2014 ◽  
Vol 39 (5) ◽  
pp. 453-457
Author(s):  
Ke-su WEI ◽  
Yong-gao TU ◽  
Ze-min SONG ◽  
Wei-chang GAO ◽  
Yi CHEN
Keyword(s):  
Chemical Substances
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