Some genetic factors linked to risk of ADHD treatment discontinuation

There has been great interest in the overlap between ADHD and substance use disorder (SUD). ADHD is a common neurobehavioural disorder of childhood that places the individual at elevated risk for later SUD. Studies have shown that 25–40% of adults and adolescents with SUD have ADHD. Although the exact link between the two disorders is still unclear, it appears their connection is complex, and involves the interplay between various biological, behavioural, and genetic factors. Early pharmacotherapy of ADHD does not increase SUD, and, in fact, appears to reduce cigarette smoking and SUD. In individuals with ADHD and SUD, stabilization of SUD is recommended initially, with consideration of adjunct non-stimulant and extended release stimulant medications. More research on the mechanisms of overlap between the disorders, preventative effects of early ADHD treatment on SUD, and concurrent treatments for ADHD and SUD are necessary.

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Genetic Factors in the Etiology of Duodenal Ulcer

Gastroenterology ◽

10.1016/s0016-5085(61)80068-1 ◽

1961 ◽

Vol 40 (3) ◽

pp. 371-378 ◽

Cited By ~ 10

Author(s):

David A. Price Evans

Keyword(s):

Duodenal Ulcer ◽

Genetic Factors

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New Approach to ADHD Treatment Tested

Pediatric News ◽

10.1016/s0031-398x(06)70824-4 ◽

2006 ◽

Vol 40 (1) ◽

pp. 24

Author(s):

DOUG BRUNK

Keyword(s):

New Approach ◽

Adhd Treatment

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A multicentre randomized controlled trial on trans-generational attention deficit/hyperactivity disorder (ADHD) in mothers and children (AIMAC): an exploratory analysis of predictors and moderators of treatment outcome

Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie ◽

10.1024/1422-4917/a000602 ◽

2019 ◽

Vol 47 (1) ◽

pp. 49-65 ◽

Cited By ~ 3

Author(s):

Charlotte Jaite ◽

Betteke Maria van Noort ◽

Timo D. Vloet ◽

Erika Graf ◽

Viola Kappel ◽

...

Keyword(s):

Treatment Outcome ◽

Primary Outcome ◽

Controlled Trial ◽

Specific Treatment ◽

Externalizing Symptoms ◽

Control Treatment ◽

Comorbid Depression ◽

Adhd Treatment ◽

Mothers And Children ◽

Maternal Adhd

Abstract. Objective: We examined predictors and moderators of treatment outcome in mothers and children diagnosed with ADHD in a large multicentre RCT. Method: In total, 144 mother-child dyads with ADHD were randomly assigned to either a maternal ADHD treatment (group psychotherapy and open methylphenidate medication, TG) or to a control treatment (individual counselling without psycho- or pharmacotherapy, CG). After maternal ADHD treatment, parent-child training (PCT) for all mother-child dyads was added. The final analysis set was based on 123 dyads with completed primary outcome assessments (TG: n = 67, CG: n = 56). The primary outcome was the change in each child’s externalizing symptoms. Multiple linear regression analyses were performed. Results: The severity of the child’s externalizing problem behaviour in the family at baseline predicted more externalizing symptoms in the child after PCT, independent of maternal treatment. When mothers had a comorbid depression, TG children showed more externalizing symptoms after PCT than CG children of depressive mothers. No differences between the treatment arms were seen in the mothers without comorbid depression. Conclusions: Severely impaired mothers with ADHD and depressive disorder are likely to need additional disorder-specific treatment for their comorbid psychiatric disorders to effectively transfer the contents of the PCT to the home situation (CCTISRCTN73911400).

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