Eosinophilia associated with clozapine therapy

2021 ◽  
Vol 32 (7) ◽  
pp. 2-2
Author(s):  
Y. W. Francis Lam
Keyword(s):  
Clozapine Therapy

Initiation of Clozapine Therapy in a Patient With Preexisting Leukopenia: A Discussion of the Rationale of Current Treatment Options

2001 ◽  
Vol 13 (4) ◽  
pp. 233-237 ◽  
Author(s):  
Roger Boshes ◽  
Theo Manschreck ◽  
Jean Desrosiers ◽  
Steven Candela ◽  
Meredith Hanrahan-Boshes
Keyword(s):  
Treatment Options ◽  
Current Treatment ◽  
Clozapine Therapy

scholarly journals Clozapine-induced myocarditis in an adolescent male with DiGeorge Syndrome

2018 ◽  
Vol 8 (6) ◽  
pp. 313-316 ◽  
Author(s):  
Ann Marie Ruhe ◽  
Imran Qureshi ◽  
David Procaccini
Keyword(s):  
Digeorge Syndrome ◽  
Rare Complication ◽  
22Q11.2 Deletion Syndrome ◽  
Adolescent Male ◽  
Deletion Syndrome ◽  
22Q11.2 Deletion ◽  
Clozapine Therapy ◽  
Chromosomal Disorder ◽  
Congenital Heart Malformations ◽  
Pediatric Populations

Abstract DiGeorge Syndrome (22q11.2 deletion syndrome) is a chromosomal disorder associated with both congenital heart malformations and schizophrenia, which is often treatment-resistant and may warrant treatment with clozapine. Clozapine-induced myocarditis (CIM) is a rare complication of clozapine therapy, with a reported incidence ranging from 0.015% to 3%. Fulminant CIM has a nonspecific presentation in both adult and pediatric populations and a mortality rate approaching 50%. Few cases of pediatric CIM have been documented in the literature. This report highlights a case of CIM in an adolescent male with DiGeorge Syndrome whose clinical course was characterized by a subtle, nonspecific presentation and resolution with supportive care.

Addition of Risperidone to Clozapine Therapy in Chronically Psychotic Inpatients

2001 ◽  
Vol 62 (2) ◽  
pp. 129-130 ◽  
Author(s):  
Izaak W. de Groot ◽  
Adolph H. Heck ◽  
Peter N. van Harten
Keyword(s):  
Clozapine Therapy

Diabetic Ketoacidosis in a Patient with Long-term Clozapine Therapy

2007 ◽  
Vol 22 (5) ◽  
pp. 376 ◽  
Author(s):  
Youn Joo Jeon ◽  
Seung-Hwan Lee ◽  
Se-Na Jang ◽  
Eun-Sun Kim ◽  
Jeong-Yo Min ◽  
...  
Keyword(s):  
Diabetic Ketoacidosis ◽  
Clozapine Therapy

Pharmacists’ role in clozapine therapy at a Veterans Affairs medical center

1994 ◽  
Vol 51 (7) ◽  
pp. 899-901 ◽  
Author(s):  
Benjamin R. Dishman ◽  
Gary L. Ellenor ◽  
Jonathan P. Lacro ◽  
James B. Lohr
Keyword(s):  
Medical Center ◽  
Veterans Affairs ◽  
Clozapine Therapy

scholarly journals Clinical and laboratory characteristics of clozapine-treated patients with schizophrenia referred to a national immunodeficiency clinic reveals a B-cell signature resembling common variable immunodeficiency (CVID)

2020 ◽  
Vol 73 (9) ◽  
pp. 587-592 ◽  
Author(s):  
Mark James Ponsford ◽  
Rachael Steven ◽  
Kathyrn Bramhall ◽  
Mathew Burgess ◽  
Sonali Wijetilleka ◽  
...  
Keyword(s):  
Common Variable Immunodeficiency ◽  
Antibody Deficiency ◽  
Case Note ◽  
Retrospective Case ◽  
Clozapine Therapy ◽  
Clozapine Treatment ◽  
Immunoglobulin Replacement ◽  
Common Variable ◽  
Case Note Review ◽  
Drug Cessation

AimsAn association between antibody deficiency and clozapine use in individuals with schizophrenia has recently been reported. We hypothesised that if clozapine-associated hypogammaglobulinaemia was clinically relevant this would manifest in referral patterns.MethodsRetrospective case note review of patients referred and assessed by Immunology Centre for Wales (ICW) between January 2005 and July 2018 with extraction of clinical and immunological features for individuals with diagnosis of schizophrenia-like illness.Results1791 adult patients were assessed at ICW during this period; 23 patients had a psychiatric diagnosis of schizophrenia or schizoaffective disorder. Principal indications for referral were findings of low calculated globulin and immunoglobulins. Clozapine was the single most commonly prescribed antipsychotic (17/23), disproportionately increased relative to reported use in the general schizophrenia population (OR 6.48, 95% CI: 1.79 to 23.5). Clozapine therapy was noted in 6/7 (86%) of patients subsequently requiring immunoglobulin replacement therapy (IgRT). Marked reduction of class-switched memory B cells (CSMB) and plasmablasts were observed in clozapine-treated individuals relative to healthy age-matched controls. Clozapine duration is associated with CSMB decline. One patient discontinued clozapine, with gradual recovery of IgG levels without use of IgRT.ConclusionsOur findings are consistent with enrichment of clozapine-treatment within schizophrenic individuals referred for ICW assessment over the last 13 years. These individuals displayed clinical patterns closely resembling the primary immunodeficiency common variable immunodeficiency, however appears reversible on drug cessation. This has diagnostic, monitoring and treatment implications for psychiatry and immunology teams and directs prospective studies to address causality and the wider implications for this patient group.

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