Antipsychotics most common drugs in bipolar disorder treatment

2020 ◽  
Vol 31 (8) ◽  
pp. 7-7
2009 ◽  
Author(s):  
Martha Sajatovic ◽  
William J. Meyer ◽  
Douglas Smith ◽  
Elizabeth Singer ◽  
Kristin A. Cassidy ◽  
...  

2018 ◽  
Vol 11 (9) ◽  
pp. dmm035600 ◽  
Author(s):  
Elizabeth Kelly ◽  
Devdutt Sharma ◽  
Christopher J. Wilkinson ◽  
Robin S. B. Williams

2010 ◽  
Vol 27 (5) ◽  
pp. 457-464 ◽  
Author(s):  
Stefanie A. Hlastala ◽  
Julie S. Kotler ◽  
Jon M. McClellan ◽  
Elizabeth A. McCauley

2018 ◽  
Vol 238 ◽  
pp. 666-673 ◽  
Author(s):  
Dominic Hodgkin ◽  
Maureen T. Stewart ◽  
Elizabeth L. Merrick ◽  
Ye Zhang Pogue ◽  
Noreen A. Reilly-Harrington ◽  
...  

2018 ◽  
Vol 20 (6) ◽  
pp. 506-514 ◽  
Author(s):  
Margaret O Akinhanmi ◽  
Joanna M Biernacka ◽  
Stephen M Strakowski ◽  
Susan L McElroy ◽  
Joyce E Balls Berry ◽  
...  

2020 ◽  
Vol 22 (6) ◽  
pp. 644-646
Author(s):  
Luisa Siqueira Rotenberg ◽  
Camila Nascimento ◽  
Tatiana Cohab Khafif ◽  
Rodrigo Silva Dias ◽  
Beny Lafer

2019 ◽  
Vol 31 (04) ◽  
pp. 230-234
Author(s):  
Ole Köhler-Forsberg ◽  
Louisa G. Sylvia ◽  
Charles L. Bowden ◽  
Joseph R. Calabrese ◽  
Michael E. Thase ◽  
...  

AbstractBackground:Immune system markers may predict affective disorder treatment response, but whether an overall immune system marker predicts bipolar disorder treatment effect is unclear.Methods:Bipolar CHOICE (N = 482) and LiTMUS (N = 283) were similar comparative effectiveness trials treating patients with bipolar disorder for 24 weeks with four different treatment arms (standard-dose lithium, quetiapine, moderate-dose lithium plus optimised personalised treatment (OPT) and OPT without lithium). We performed secondary mixed effects linear regression analyses adjusted for age, gender, smoking and body mass index to investigate relationships between pre-treatment white blood cell (WBC) levels and clinical global impression scale (CGI) response.Results:Compared to participants with WBC counts of 4.5–10 × 109/l, participants with WBC < 4.5 or WBC ≥ 10 showed similar improvement within each specific treatment arm and in gender-stratified analyses.Conclusions:An overall immune system marker did not predict differential treatment response to four different treatment approaches for bipolar disorder all lasting 24 weeks.


2015 ◽  
Vol 28 (2) ◽  
pp. 75-84 ◽  
Author(s):  
Louise Bjørklund ◽  
Henriette Thisted Horsdal ◽  
Ole Mors ◽  
Søren Dinesen Østergaard ◽  
Christiane Gasse

ObjectiveIn bipolar disorder, treatment with antidepressants without concomitant use of mood stabilisers (antidepressant monotherapy) is associated with development of mania and rapid cycling and is therefore not recommended. The present study aimed to investigate the psychopharmacological treatment patterns in bipolar disorder over time, with a focus on antidepressant monotherapy.MethodsCohort study with annual cross-sectional assessment of the use of psychotropic medications between 1995 and 2012 for all Danish residents aged 10 years or older with a diagnosis of bipolar disorder registered in the Danish Psychiatric Central Research Register. Users of a given psychotropic medication were defined as individuals having filled at least one prescription for that particular medication in the year of interest.ResultsWe identified 20 618 individuals with bipolar disorder. The proportion of patients with bipolar disorder using antidepressants, atypical antipsychotics and anticonvulsants increased over the study period, while the proportion of patients using lithium, typical antipsychotics and benzodiazepines/sedatives decreased. The proportion of patients treated with antidepressant monotherapy decreased from 20.5% in 1997 to 12.1% in 2012, and among antidepressant users, the proportion in monotherapy decreased from 47.7% to 23.9%, primarily driven by a decrease in the use of tricyclic antidepressants.ConclusionThe results show an increase in the proportion of patients with bipolar disorder being treated with antidepressants in the period from 1997 to 2012. However, in accordance with international treatment guidelines, the extent of antidepressant monotherapy decreased during the same period.


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