Lamotrigine improves bipolar depression, but folic acid counteracts effects

2016 ◽  
Vol 27 (4) ◽  
pp. 1-6
Keyword(s):  
Folic Acid ◽  
Bipolar Depression

scholarly journals Comparative economic evaluation of quetiapine plus lamotrigine combination vs quetiapine monotherapy (and folic acid vs placebo) in patients with bipolar depression (CEQUEL)

2018 ◽  
Vol 20 (8) ◽  
pp. 733-745 ◽  
Author(s):  
Judit Simon ◽  
John R. Geddes ◽  
Alexandra Gardiner ◽  
Jennifer Rendell ◽  
Guy M. Goodwin ◽  
...  
Keyword(s):  
Folic Acid ◽  
Economic Evaluation ◽  
Bipolar Depression

scholarly journals Biochemical and genetic predictors and correlates of response to lamotrigine and folic acid in bipolar depression: Analysis of the CEQUEL clinical trial

2017 ◽  
Vol 19 (6) ◽  
pp. 477-486 ◽  
Author(s):  
EM Tunbridge ◽  
MJ Attenburrow ◽  
A Gardiner ◽  
JM Rendell ◽  
C Hinds ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Folic Acid ◽  
Bipolar Depression ◽  
Genetic Predictors

The Morphology of the Rat Kidney Following Folic Acid Administration

1970 ◽  
Vol 28 ◽  
pp. 200-201
Author(s):  
Aline Byrnes ◽  
Elsa E. Ramos ◽  
Minoru Suzuki ◽  
E.D. Mayfield
Keyword(s):  
Folic Acid ◽  
De Novo ◽  
Specific Activity ◽  
Rat Kidney ◽  
Present Report ◽  
Intracellular Localization ◽  
Male Rats ◽  
Renal Hypertrophy ◽  
Electron Microscopic ◽  
Biochemical Alterations

Renal hypertrophy was induced in 100 g male rats by the injection of 250 mg folic acid (FA) dissolved in 0.3 M NaHCO3/kg body weight (i.v.). Preliminary studies of the biochemical alterations in ribonucleic acid (RNA) metabolism of the renal tissue have been reported recently (1). They are: RNA content and concentration, orotic acid-c14 incorporation into RNA and acid soluble nucleotide pool, intracellular localization of the newly synthesized RNA, and the specific activity of enzymes of the de novo pyrimidine biosynthesis pathway. The present report describes the light and electron microscopic observations in these animals. For light microscopy, kidney slices were fixed in formalin, embedded, sectioned, and stained with H & E and PAS.

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