Effect ofMangifera indicaL. extract (QF808) on protein and hepatic microsome peroxidation

2001 ◽  
Vol 15 (7) ◽  
pp. 581-585 ◽  
Author(s):  
Gregorio Martínez ◽  
Attilia Giuliani ◽  
Olga Sonia León ◽  
Gema Pérez ◽  
Alberto J Núñez Selles
Keyword(s):  
Hepatic Microsome

Cytosolic potentiation of the rat hepatic microsome mediated mutagenicity of benzidine

Mutagenesis ◽  
1987 ◽  
Vol 2 (3) ◽  
pp. 205-209 ◽  
Author(s):  
Jonathan N. Smith ◽  
Costas Ioannides
Keyword(s):  
Hepatic Microsome

scholarly journals Experimental Adjustment on Drug Interactions through Intestinal CYP3A Activity in Rat: Impacts of Kampo Medicines Repeat Administered

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Natsumi Kinoshita ◽  
Yuriko Yamaguchi ◽  
Xiao-Long Hou ◽  
Kyoko Takahashi ◽  
Koichi Takahashi
Keyword(s):  
Herbal Drugs ◽  
Individual Effect ◽  
Cyp3a Activity ◽  
Hepatic Microsome ◽  
Key Factor ◽  
Pre Treatment ◽  
The Individual ◽  
Intestinal Microsome

To provide the information that is necessary for making the proper use of kampo medicines, we have proposed the adequate methodology focused on the following issues: (i) kampo medicines emphasize the effects produced by the combination of herbal drugs rather than the individual effect of any single herb and (ii) Intestinal CYP3A has become a key factor for the bioavailability of orally administrated drugs. In the present study, we investigated both thein vivoandin vitroeffects of Saireito and Hochuekkito (kampo formulas) on CYP3A activities. From our study, oral pre-treatment with Saireito or Hochuekkito did not affect the pharmacokinetics of nifedipine after intravenous administration to rats. When nifedipine was administered to rat intrajejunum, a significant decrease of AUC was showed by pre-treatment with both kampo formulas. Saireito pre-treatment led to 80% decrease in of nifedipine. Saireito caused significant increases in both protein expression and metabolic activity of CYP3A in intestinal microsome, whereas it had no effect on CYP3A in hepatic microsome. Our result also showed that this affect of Saireito can be gone by wash-out with 1 week. These findings demonstrated that Saireito may induce CYP3A activity of intestine but not of liver in rats. When resources for research are limited, well-designed scientific studies except clinical trials also have many advantages.

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