Efficacy and safety of therapeutic use of cannabis derivatives and their synthetic analogs: Overview of systematic reviews

2021 ◽  
Author(s):  
Rachel Riera ◽  
Rafael Leite Pacheco ◽  
Ângela Maria Bagattini ◽  
Ana Luiza Cabrera Martimbianco
Keyword(s):  
Systematic Reviews ◽  
Therapeutic Use ◽  
Efficacy And Safety ◽  
Synthetic Analogs ◽  
Overview Of Systematic Reviews

scholarly journals Efficacy and safety of acupuncture in children: an overview of systematic reviews

2015 ◽  
Vol 78 (2) ◽  
pp. 112-119 ◽  
Author(s):  
Chunsong Yang ◽  
Zilong Hao ◽  
Ling-Li Zhang ◽  
Qin Guo
Keyword(s):  
Systematic Reviews ◽  
Efficacy And Safety ◽  
Overview Of Systematic Reviews

scholarly journals Effectiveness and Safety of Acupuncture and Moxibustion in Pregnant Women with Noncephalic Presentation: An Overview of Systematic Reviews

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Maite Miranda-Garcia ◽  
Cristina Domingo Gómez ◽  
Cristina Molinet-Coll ◽  
Betina Nishishinya ◽  
Ikram Allaoui ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Pregnant Women ◽  
Systematic Reviews ◽  
Breech Presentation ◽  
Lower Probability ◽  
Efficacy And Safety ◽  
Considerable Heterogeneity ◽  
Pregnancy And Childbirth ◽  
Acupuncture And Moxibustion ◽  
Overview Of Systematic Reviews

Background. Breech presentation at the time of delivery is 3.8–4%. Fetuses that maintain a noncephalic presentation beyond 32 weeks will have a lower probability of spontaneous version before labor. Given the increasing interest in exploring the use of complementary medicine during pregnancy and childbirth, the moxibustion technique, a type of traditional Chinese medicine, could be another option to try turning a breech baby into a cephalic presentation. Objectives. To review the evidence from systematic reviews (SR) on the efficacy and safety of acupuncture and moxibustion in pregnant women with noncephalic presentation. Main Results. Our SR synthesizes the results from five clinical trials on pregnant women with a singleton noncephalic presentation. There is evidence that moxibustion reduces the number of noncephalic presentations at the time of birth compared with no treatment. The adverse effects that acupuncture and moxibustion can cause seem to be irrelevant. Most SRs agree that there are no adverse effects directly related to acupuncture and moxibustion. Conclusions. Even though the results obtained are positive and the five reviews conclude that moxibustion reduces the number of noncephalic presentations at birth (alone or combined with postural techniques or acupuncture), there is considerable heterogeneity between them. Better methodologically designed studies are required in the future to reaffirm this conclusion.

scholarly journals Efficacy and safety of acupuncture therapy for psoriasis: an overview of systematic reviews

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Mingyi Jing ◽  
Lanhui Shi ◽  
Yuzhen Zhang ◽  
Mei Zhu ◽  
Fan Yuan ◽  
...  
Keyword(s):  
Acupuncture Therapy ◽  
Systematic Reviews ◽  
Efficacy And Safety ◽  
Overview Of Systematic Reviews

Effects of glutamine supplementation on critically ill patients: Focus on efficacy and safety. An overview of systematic reviews

Nutrition ◽  
2020 ◽  
Vol 78 ◽  
pp. 110960
Author(s):  
Aikaterini Apostolopoulou ◽  
Anna-Bettina Haidich ◽  
Konstantinia Kofina ◽  
William Manzanares ◽  
Emmanouil Bouras ◽  
...  
Keyword(s):  
Critically Ill ◽  
Systematic Reviews ◽  
Critically Ill Patients ◽  
Glutamine Supplementation ◽  
Efficacy And Safety ◽  
Overview Of Systematic Reviews

scholarly journals Effect of phosphodiesterase-type 5 inhibitors on erectile function: an overview of systematic reviews and meta-analyses

BMJ Open ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. e047396 ◽  
Author(s):  
Nikolaos Pyrgidis ◽  
Ioannis Mykoniatis ◽  
Anna-Bettina Haidich ◽  
Maria Tirta ◽  
Persefoni Talimtzi ◽  
...  
Keyword(s):  
Systematic Reviews ◽  
Erectile Function ◽  
Treatment Modalities ◽  
Cochrane Library ◽  
Extensive Literature ◽  
Efficacy And Safety ◽  
Phosphodiesterase Type 5 Inhibitors ◽  
Overview Of Systematic Reviews ◽  
Phosphodiesterase Type ◽  
Meta Analyses

IntroductionPhosphodiesterase-type 5 inhibitors (PDE5i) are the recommended first-line treatment for erectile dysfunction. Previous systematic reviews and meta-analyses suggest that they are a safe and effective option in many patient groups. Similarly, PDE5i may be effective as part of combination therapy in non-responders to PDE5i. We will generate an overview of systematic reviews, meta-analyses and network meta-analyses aiming to summarise the available knowledge regarding the efficacy and safety of PDE5i in the general population and in multiple subgroups of patients.Methods and analysisThis overview was designed in accordance with the PRIO-harms and Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines and its protocol was registered at PROSPERO. We will systematically search PubMed, Web of Science, Cochrane Library and Scopus databases from inception to November 2020 without any language restrictions. We will include systematic reviews or meta-analyses: (1) comparing the efficacy and safety of any dose of PDE5i with each other, with placebo or with other effective treatments for the management of erectile function; (2) exploring the use of any PDE5i alone or in combination with other treatment modalities in the general male population or in specific subgroups and (3) conducted with systematic procedures. Our overview will employ the AMSTAR 2 tool to evaluate the quality of the included studies and the Grading of Recommendations Assessment, Development and Evaluation approach to assess the strength of evidence for all outcomes. We will construct forest plots of risk estimates with the corresponding CI for all outcomes.Ethics and disseminationIn this overview, we will undertake an extensive literature search in an attempt to evaluate the potential benefits and risks of treatment with one PDE5i versus another or versus placebo and provide recommendations for clinicians and policy-makers. No ethical approval is required.PROSPERO registration numberCRD42020216754.

Efficacy and safety of acupuncture for hypertension: An overview of systematic reviews

2019 ◽  
Vol 34 ◽  
pp. 185-194 ◽  
Author(s):  
Huimin Zhao ◽  
Dan Li ◽  
Yuling Li ◽  
Ying Yang ◽  
Yueting Liu ◽  
...  
Keyword(s):  
Systematic Reviews ◽  
Efficacy And Safety ◽  
Overview Of Systematic Reviews

scholarly journals Efficacy and safety of intra-articular therapies in rheumatic and musculoskeletal diseases: an overview of systematic reviews

RMD Open ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. e001658
Author(s):  
Sebastián Cruz Rodriguez-García ◽  
Raul Castellanos-Moreira ◽  
Jacqueline Uson ◽  
Esperanza Naredo ◽  
Terence W O'Neill ◽  
...  
Keyword(s):  
Systematic Reviews ◽  
Musculoskeletal Diseases ◽  
Platelet Rich Plasma ◽  
Hip Osteoarthritis ◽  
Measurement Tool ◽  
Efficacy And Safety ◽  
Eular Recommendations ◽  
Overview Of Systematic Reviews ◽  
Randomised Controlled ◽  
And Function

ObjectiveTo summarise the evidence on intra-articular therapies (IAT) to inform the 2020 EULAR recommendations.MethodsAn overview of systematic reviews (SR) including randomised-controlled trials (RCTs) of IAT in adults with arthropathies was performed up to July 2020. Pain, function, and frequency of adverse events were the main efficacy and safety outcomes, respectively. Quality was assessed with the A MeaSurement Tool to Assess Systematic Reviews (AMSTAR)-2 tool.ResultsOf 184 references identified, 16 met the inclusion criteria, and a search of their reference lists identified 16 additional SRs. After quality assessment, 29 were finally included. Of these, 18 focused on knee osteoarthritis (KOA), 6 on hip osteoarthritis (HOA), 3 on shoulder capsulitis (SC), and 3 on rheumatoid arthritis. Overall, hyaluronic acid showed a small effect on pain and function in KOA but not in HOA or shoulder capsulitis. Intra-articular glucocorticoids showed a small effect in pain and function in KOA and function in HOA and SC. Platelet-rich plasma showed benefit in pain and function in KOA but not in HOA. Mesenchymal stem cells behaved similarly. Most SR results were of moderate quality and RCTs included often presented a high risk of bias, mainly due to inadequate blinding and heterogeneous results. All interventions were well tolerated with no clear safety differences.ConclusionsThis overview underlines that most IAT currently used in KOA, HOA, and SC exert small effects and are well tolerated. However, no firm conclusions can be drawn for inflammatory arthritis due to the limited data found.

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