Anthocyanin‐rich fraction from black rice, Oryza sativa L. var. indica “Luem Pua,” bran extract attenuates kidney injury induced by high‐fat diet involving oxidative stress and apoptosis in obese rats

2021 ◽  
Author(s):  
Pongrapee Laorodphun ◽  
Phatchawan Arjinajarn ◽  
Laongdao Thongnak ◽  
Sasivimon Promsan ◽  
Myat Theingi Swe ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oryza Sativa ◽  
High Fat Diet ◽  
Oryza Sativa L ◽  
Kidney Injury ◽  
Black Rice ◽  
High Fat ◽  
Obese Rats

scholarly journals Perubahan kadar kolesterol total dan trigliserida pada kelinci New Zealand white yang diberi ekstrak beras hitam (Oriza sativa L.)

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Lastry Glory ◽  
Shirley E. Kawengian ◽  
Nelly Mayulu
Keyword(s):  
Oryza Sativa ◽  
New Zealand ◽  
Total Cholesterol ◽  
High Fat Diet ◽  
Oryza Sativa L ◽  
White Male ◽  
Control Group ◽  
Black Rice ◽  
High Fat ◽  
Standard Meal

Abstract: High cholesterol levels in blood can lead to various diseases, including coronary heart disease. Black rice (Oryza sativa L.) contains more anthocyanin in layers of alueron than in white rice. Cardioprotective effect of rice has been emerged since several decades ago. This was a true experimental study with a pre-posttest control group design. Samples were New Zealand White male rabbits aged 3 months. Group 1 was fed standard meal; group 2 was fed with high-fat diet; group 3 was fed with high-fat diet plus black rice extract; and group 4 were fed with high-fat diet plus atorvastatin. Data were analyzed and presented descriptively. The results showed that total cholesterol and triglyceride levels in the group fed with black rice extract decreased by 5 mg/dl and 4 mg/dl respectively. Decreased total cholesterol and triglyceride levels were also found in the group fed with standard meal and the group given atorvastatin. Meanwhile, the group fed with high-fat diet showed increased levels of total cholesterol and triglyceride high enough. Conclusion: There were decreased levels of total cholesterol and triglycerides in rabbits fed with black rice extract. Keywords: black rice extract, total cholesterol, triglycerides. Abstrak: Kadar kolesterol yang tinggi dalam darah dapat memicu berbagai macam penyakit, diantaranya penyakit jantung koroner. Beras hitam (Oryza sativa L.) mengandung lebih banyak antosianin dalam lapisan alueronnya dibandingkan beras putih. Efek kardioprotektif dari beras telah dikemukakan sejak beberapa dekade yang lalu. Jenis penelitian ini true experimental dengan pre test post test control grup design. Sampel ialah kelinci New Zealand White jantan berusia 3 bulan. Kelompok perlakuan 1 diberi pakan standar; kelompok 2 diberi diet tinggi lemak; kelompok 3 diberi diet tinggi lemak dan ekstrak beras hitam dan kelompok 4 diberi diet tinggi lemak dan atorvastatin. Data dianalisis dan disajikan secara deskriptif. Hasil penelitian memperlihatkan kadar kolesterol total dan trigliserida pada kelompok yang diberi ekstrak beras hitam mengalami penurunan masing-masing sebesar 5 mg/dl dan 4 mg/dl. Penurunan kadar kolesterol dan trigliserida juga terdapat pada kelompok yang diberi pakan standar dan kelompok yang diberi atorvastatin. Pada kelompok yang diberi diet tinggi lemak terjadi peningkatan kadar kolesterol total dan trigliserida yang cukup besar. Simpulan: Terjadi penurunan kadar kolesterol total dan trigliserida pada kelinci yang diberi ekstrak beras hitam.Kata kunci: ekstrak beras hitam, kolesterol total, trigliserid.

scholarly journals Gambaran histologik aorta kelinci yang diinduksi dengan lemak babi dan diberi ekstrak beras hitam

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Lendy S.F. Polii ◽  
Djon Wongkar ◽  
Sunny Wangko
Keyword(s):  
Oryza Sativa ◽  
New Zealand ◽  
High Fat Diet ◽  
Oryza Sativa L ◽  
Foam Cells ◽  
Black Rice ◽  
High Fat ◽  
Cholesterol Levels ◽  
Post Test ◽  
Group A

Abstract: Dyslipidemia is an abnormal lipid metabolism, marked by the alteration of lipid fractions within the blood plasma. World Health Organization reported that dyslipidemia was associated with heart diseases in general with 4 million deaths each year. Dyslipidemia is mostly caused by unhealthy lifestyle. The change of lifestyle can be initiated by the modification of diet. Black rice (Oryza sativa L.) is a type of local rice which contains a different pigment than the regular or any other colored rice. This study aimed to identify the histological changes of rabbit aorta induced with lard and black rice extract diet. This was an experimental study with a post-test design. Subjects were three rabbits New Zealand white divided into 3 groups (A. B. And C) of 1 rabbit each. Group A was fed with standard diet (Vitamax), group B with high fat diet, meanwhile group C was fed with high fat diet added with black rice extracts. This study was carried out for 28 days, after that all the rabbits were terminated to obtain their aortas. The results showed that there were reductions of LDL and total cholesterol levels of group C. Foam cells were found in the tunica intima and tunica media in group A, B and C. However, the foam cells in group C were less than the other groups. Conclusion: Black rice diet could reduce the LDL and total cholesterol levels as well as the number of foam cells in the aorta tunica of rabbits. Keywords: aorta, rabbits, foam cells, black rice extracts, lard Abstrak: Dislipidemia adalah kelainan metabolisme lipid yang ditandai dengan peningkatan maupun penurunan fraksi lipid dalam plasma. WHO memperkirakan dislipidemia berhubungan dengan kasus penyakit jantung secara luas, serta menyebabkan empat juta kematian per tahun. Dislipidemia umumnya disebabkan karena gaya hidup. Perubahan gaya hidup dapat dilakukan mulai dari memodifikasi pola diet. Beras hitam (Oryza sativa L.) merupakan varietas lokal yang mengandung pigmen berbeda dengan beras putih atau beras berwarna lain. Penelitian ini bertujuan untuk mendapatkan gambaran histologik aorta kelinci yang diinduksi dengan lemak babi dan diberi pakan beras hitam. Jenis penelitian ini eksperimental dengan rancangan post test. Subyek penelitian kelinci New Zealand white dibagi menjadi tiga kelompok (A, B, dan C), masing-masing kelompok terdiri dari 1 kelinci. Kelompok A diberikan pakan standar (Vitamax), kelompok B diberikan diet tinggi lemak, dan kelompok C diberikan diet tinggi lemak serta ekstrak beras hitam. Perlakuan diberikan selama 28 hari dan selanjutnya dilakukan terminasi untuk mengambil aorta kelinci dan kemudian dianalisis. Hasil penelitian memperlihatkan penurunan kadar kolesterol LDL dan total pada kelompok C. Gambaran histologik aorta kelompok A, B dan C menunjukkan adanya sel-sel busa di lapisan tunika intima dan tunika media, namun jumlah sel busa di kelompok C lebih sedikit dari kelompok yang lain. Simpulan: Ekstrak beras hitam dapat menurunkan kadar kolesterol LDL dan total, serta jumlah sel busa di lapisan aorta pada kelinci.Kata kunci: aorta, kelinci, sel busa, ekstrak beras hitam, lemak babi

scholarly journals Black rice (Oryza sativa L.) extract attenuates hepatic steatosis in C57BL/6 J mice fed a high-fat diet via fatty acid oxidation

2012 ◽  
Vol 9 (1) ◽  
pp. 27 ◽  
Author(s):  
Hwan-Hee Jang ◽  
Mi-Young Park ◽  
Heon-Woong Kim ◽  
Young-Min Lee ◽  
Kyung-A Hwang ◽  
...  
Keyword(s):  
Oryza Sativa ◽  
Fatty Acid ◽  
Hepatic Steatosis ◽  
Fatty Acid Oxidation ◽  
High Fat Diet ◽  
Oryza Sativa L ◽  
Acid Oxidation ◽  
Black Rice ◽  
High Fat

scholarly journals Black rice (Oryza sativa L.) reduces obesity and improves lipid metabolism in C57BL/6J mice fed a high-fat diet

2020 ◽  
Vol 64 ◽  
pp. 103605 ◽  
Author(s):  
Dong Liu ◽  
Yanglin Ji ◽  
Jiang Zhao ◽  
Huali Wang ◽  
Yatu Guo ◽  
...  
Keyword(s):  
Oryza Sativa ◽  
Lipid Metabolism ◽  
High Fat Diet ◽  
Oryza Sativa L ◽  
Black Rice ◽  
High Fat

scholarly journals Perubahan kadar LDL dan HDL pada kelinci New Zealand White yang diberi ekstrak beras hitam (Oryza sativa L.)

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Jessica G. Runtu ◽  
Shirley E.S. Kawengian ◽  
Nelly Mayulu ◽  
Alexander S.L. Bolang
Keyword(s):  
Oryza Sativa ◽  
New Zealand ◽  
High Fat Diet ◽  
Oryza Sativa L ◽  
Diet Group ◽  
Standard Diet ◽  
Black Rice ◽  
High Fat ◽  
Increased Risk ◽  
The Mean

Abstract: Cardiovascular disease, especially coronary heart disease (CHD), is the leading cause of death annually. Low HDL and high LDL levels are related to the increased risk of CHD. Polyphenol such as anthocyanin in black rice could reduce the cardiovascular risks due to its antioxidant that has anti-platelet and anti-inflammatory activities. This study was aimed to determine the changes in LDL and HDL levels in rabbits fed with black rice extract (Oryza sativa L.). This was a true experimental study with a pretest posttest control group design. Samples were male New Zealand White rabbits, weighing 0.8-2.5 kg divided into four groups. Group A was fed with standard diet; group B was fed with high-fat diet; group C was fed with high-fat diet and black rice extract; and group D was fed with high-fat diet and atorvastatin. Data were presented descriptively. The results showed that the mean LDL level of group C increased by 6.5 mg/dl but one sample showed a decrease of 2 mg/dl. The mean level of HDL of group C decreased 0.50 mg/dl. This reduction was not as many as the other groups but one sample showed an increase of 5 mg/dl. Conclusion: Not all rabbits fed with black rice extract showed decreased LDL level and increased HDL level.Keywords: LDL, HDL, black rice extract Abstrak: Penyakit kardiovaskuler terutama penyakit jantung koroner (PJK) merupakan penyebab kematian tertinggi pertahunnya. Kadar HDL rendah serta kadar LDL tinggi berkaitan dengan meningkatnya risiko PJK. Polifenol seperti antosianin yang terdapat dalam beras hitam dapat menurunkan risiko penyakit kardiovaskular karena antioksidannya dengan aktivitas anti-platelet dan anti-inflamasi. Penelitian ini bertujuan untuk mengetahui perubahan kadar LDL dan HDL pada kelinci yang diberi ekstrak beras hitam (Oryza sativa L.). Jenis penelitian ialah true experimental dengan desain pre test post test control grup. Sampel ialah kelinci New Zealand White jantan, berat badan 0,8- 2,5 kg. Kelompok A diberi pakan standar; kelompok B diberi diet tinggi lemak; kelompok C diberi diet tinggi lemak dan ekstrak beras hitam; dan kelompok D diberi diet tinggi lemak dan atorvastatin. Data disajikan secara deskriptif. Hasil penelitian mendapatkan pada kelompok C, rerata kadar LDL meningkat 6,5 mg/dl tetapi satu sampel mengalami penurunan sebesar 2 mg/dl. Rerata kadar HDL pada kelompok C menurun 0,50 mg/dl; penurunan ini tidak sebesar pada kelompok lainnya tetapi satu sampel mengalami peningkatan sebesar 5 mg/dl. Simpulan: Kelinci yang diberi ekstrak beras hitam tidak semua mengalami penurunan kadar LDL dan peningkatan kadar HDL. Kata kunci: LDL, HDL, Ekstrak beras hitam

scholarly journals Strawberry Intake Ameliorates Oxidative Stress and Decreases GABA Levels Induced by High-Fat Diet in Frontal Cortex of Rats

Antioxidants ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 70 ◽  
Author(s):  
Cuauhtémoc Sandoval-Salazar ◽  
Cecilia Oviedo-Solís ◽  
Edmundo Lozoya-Gloria ◽  
Herlinda Aguilar-Zavala ◽  
Martha Solís-Ortiz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Oxidative Damage ◽  
Frontal Cortex ◽  
Protein Oxidation ◽  
High Fat Diet ◽  
High Fat ◽  
Gaba Concentration ◽  
Obese Rats ◽  
Lipid And Protein Oxidation

It has been proposed that there is a correlation between high-fat diet (HFD), oxidative stress and decreased γ-aminobutyric acid (GABA) levels, but this has not been thoroughly demonstrated. In the present study, we determined the effects of strawberry extract intake on the oxidative stress and GABA levels in the frontal cortex (FC) of obese rats. We observed that an HFD increased lipid and protein oxidation, and decreased GABA levels. Moreover, UV-irradiated strawberry extract (UViSE) decreased lipid peroxidation but not protein oxidation, whereas non-irradiated strawberry extract (NSE) reduced protein oxidation but not lipid peroxidation. Interestingly, NSE increased GABA concentration, whereas UViSE was not as effective. In conclusion, our results suggest that an HFD increases oxidative damage in the FC, whereas strawberry extract intake may ameliorate the disturbances associated with HFD-induced oxidative damage.

scholarly journals Cardiac tissue oxidative stress and inflammation after vitamin D administrations in high fat- diet induced obese rats

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Mahdieh Abbasalizad Farhangi ◽  
Ghazaleh Nameni ◽  
Ghazaleh Hajiluian ◽  
Mehran Mesgari-Abbasi
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
High Fat Diet ◽  
Cardiac Tissue ◽  
High Fat ◽  
Obese Rats
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