Erianin inhibits human lung cancer cell growth via PI3K /Akt/ mTOR pathway in vitro and in vivo

2021 ◽  
Author(s):  
Hui‐qiong Zhang ◽  
Xiao‐fang Xie ◽  
Gang‐min Li ◽  
Jun‐ren Chen ◽  
Meng‐ting Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Human Lung Cancer Cell

scholarly journals Atypical Protein Kinase Cι Plays a Critical Role in Human Lung Cancer Cell Growth and Tumorigenicity

2005 ◽  
Vol 280 (35) ◽  
pp. 31109-31115 ◽  
Author(s):  
Roderick P. Regala ◽  
Capella Weems ◽  
Lee Jamieson ◽  
John A. Copland ◽  
E. Aubrey Thompson ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Protein Kinase ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Lung ◽  
Critical Role ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Human Lung Cancer Cell

scholarly journals In vitro and in vivo properties of CD133 expressing cells from human lung cancer cell lines

2013 ◽  
Vol 2 (1) ◽  
pp. 16 ◽  
Author(s):  
Ping Wang ◽  
Zhenhe Suo ◽  
Mengyu Wang ◽  
Hanne K Høifødt ◽  
Øystein Fodstad ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Lung ◽  
Cancer Cell Lines ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell

scholarly journals Targeting PRMT5/Akt signalling axis prevents human lung cancer cell growth

2018 ◽  
Vol 23 (2) ◽  
pp. 1333-1342 ◽  
Author(s):  
Shikui Zhang ◽  
Yaqiong Ma ◽  
Xiaoyan Hu ◽  
Yonghua Zheng ◽  
Xiaoke Chen
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Human Lung Cancer Cell

Long non-coding RNA EPIC1 promotes human lung cancer cell growth

2018 ◽  
Vol 503 (3) ◽  
pp. 1342-1348 ◽  
Author(s):  
Bing Zhang ◽  
Hui-Yu Lu ◽  
Yun-Hong Xia ◽  
Ai-Gui Jiang ◽  
Yu-Xin Lv
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Human Lung Cancer Cell ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Suppression of human lung cancer cell growth and migration by berbamine

2009 ◽  
Vol 62 (4) ◽  
pp. 341-348 ◽  
Author(s):  
Huiying Duan ◽  
Jinling Luan ◽  
Qian Liu ◽  
Kazumi Yagasaki ◽  
Guoying Zhang
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Cell Growth And Migration ◽  
Human Lung Cancer Cell ◽  
And Migration

scholarly journals Activation of ERK and Mutual Regulation of Stat3 and SP1 Contribute to Inhibition of PDK1 Expression by Atractylenolide-1 in Human Lung Cancer Cells

2017 ◽  
Vol 43 (6) ◽  
pp. 2353-2366 ◽  
Author(s):  
Qian Xiao ◽  
Fang Zheng ◽  
JingJing Wu ◽  
Qing Tang ◽  
Wei Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Protein Expressions ◽  
Mutual Regulation

Background/Aims: Atractylodes macrocephula Koidz is an important ingredient in traditional Chinese herbs. One major bioactive compound, atractylenolide-1 (ATL-1), was reported to have anti-inflammatory and anti-tumor activities. However, the underlying molecular mechanism associated to this has not been well elucidated. Methods: Cell viability and cell cycle distribution were measured using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and flow cytometry assays, respectively. Western blot analysis was performed to examine the phosphorylation and protein expression of extracellular signaling-regulated kinase 1/2 (ERK1/2), signal transducer and activator of transcription 3 (Stat3), 3-phosphoinositide dependent protein kinase-1 (PDK1) and transcription factor SP1. QRT-PCR was used to examine the mRNA levels of PDK1 gene. Exogenously expressions of Stat3, PDK1 and SP1 were carried out by transient transfection assays. PDK1 promoter activity was measured by Secrete-Pair Dual Luminescence Assay Kit. A nude mice xenograft model was used to confirm the findings in vitro. Results: We showed that ATL-1 inhibited human lung cancer cell growth and induced cell cycle arrest. Furthermore, we found that ATL-1 stimulated phosphorylation of ERK1/2, inhibited phosphorylation and protein expressions of Stat3 and SP1; the latter were abrogated in the presence of MEK/ERK inhibitor PD98059. Moreover, ATL-1 reduced the protein, mRNA expression and promoter activity of PDK1. Intriguingly, exogenously expressed Stat3 and SP1 overcame ATL-1-inhibited SP1 and Stat3, and PDK1 protein expressions, respectively. Moreover, overexpression of PDK1 resisted the ATL-1-inhibited lung cancer cell growth. In consistent with the results in vitro, ATL-1 inhibited tumor growth, protein expressions of Stat3, SP1 and PDK1, and induced phosphorylation of ERK1/2 in vivo. Conclusion: In summary, our results show that ATL-1 inhibits lung cancer cell growth through activation of ERK1/2, followed by suppressing SP1 protein expression. ATL-1 also reduces phosphorylation and protein levels of Stat3. These are mutual regulation between Stat3 and SP1 proteins affected by ATL-1. This ultimately suppresses PDK1 gene expression. This study reveals a novel mechanism by which ATL-1 inhibits growth of lung cancer cells. Thus, targeting PDK1 pinpoints a potential in the lung cancer treatment.

scholarly journals ZAK inhibits human lung cancer cell growth via ERK and JNK activation in an AP-1-dependent manner

2010 ◽  
Vol 101 (6) ◽  
pp. 1374-1381 ◽  
Author(s):  
Jaw-Ji Yang ◽  
Yi-Ju Lee ◽  
Hsin-Hung Hung ◽  
Wei-Pu Tseng ◽  
Chuan-Chou Tu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Dependent Manner ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Human Lung Cancer Cell ◽  
Jnk Activation
Sign in / Sign up

Export Citation Format

Share Document