The effect of Cornus mas extract consumption on bone biomarkers and inflammation in postmenopausal women: A randomized clinical trial

2021 ◽  
Author(s):  
Naheed Aryaeian ◽  
Fatemehsadat Amiri ◽  
Seyedeh Tayebeh Rahideh ◽  
Jamileh Abolghasemi ◽  
Shima Jazayeri ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Postmenopausal Women ◽  
Randomized Clinical Trial ◽  
Bone Biomarkers ◽  
Cornus Mas

The effect of Cornus mas fruit extract consumption on lipid profile, glycemic indices, and leptin in postmenopausal women— A randomized clinical trial

2019 ◽  
Vol 33 (11) ◽  
pp. 2979-2988 ◽  
Author(s):  
Afsane Gholamrezayi ◽  
Naheed Aryaeian ◽  
Shahnaz Rimaz ◽  
Jamileh Abolghasemi ◽  
Soudabeh Fallah ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Lipid Profile ◽  
Postmenopausal Women ◽  
Randomized Clinical Trial ◽  
Fruit Extract ◽  
Cornus Mas ◽  
Glycemic Indices

Randomized clinical trial of tamoxifen alone or combined with fluoxymesterone in postmenopausal women with metastatic breast cancer.

1988 ◽  
Vol 6 (5) ◽  
pp. 825-831 ◽  
Author(s):  
J N Ingle ◽  
D I Twito ◽  
D J Schaid ◽  
S A Cullinan ◽  
J E Krook ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Metastatic Breast Cancer ◽  
Side Effects ◽  
Postmenopausal Women ◽  
Randomized Clinical Trial ◽  
Statistical Significance ◽  
Metastatic Breast ◽  
Rank Test ◽  
Breast Cancer Patients

A randomized clinical trial was performed to determine if combination hormonal therapy with tamoxifen (TAM) and fluoxymesterone (FLU) was more efficacious than TAM alone for the treatment of postmenopausal women with metastatic breast cancer. Patients failing TAM could subsequently receive FLU. The dose of both drugs was 10 mg orally twice daily. Objective responses were seen in 50 of 119 TAM patients (42%) and 63 of 119 TAM plus FLU patients (53%) (one-sided P = .05). Time to disease progression distributions were better for TAM plus FLU (median, 350 days v 199 days), but the log rank test only approached statistical significance (one-sided P = .07). Duration of response and survival distributions were similar between the two treatment arms. Toxicities, in terms of androgenic side effects, were greater on the TAM plus FLU regimen. Fifty-two patients are evaluable for response with FLU following TAM and 21 (40%) have achieved a response. We conclude that the advantages in terms of response rate and time to progression observed with TAM plus FLU probably represent a biological effect, but are not of sufficient magnitude to justify the routine clinical use of this combination given the lack of survival advantage and side effects encountered.

Effects of phytoestrogen supplementation in postmenopausal women with dry eye syndrome: a randomized clinical trial

2012 ◽  
Vol 47 (6) ◽  
pp. 489-492 ◽  
Author(s):  
Gianluca Scuderi ◽  
Maria Teresa Contestabile ◽  
Caterina Gagliano ◽  
Daniela Iacovello ◽  
Luca Scuderi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Postmenopausal Women ◽  
Randomized Clinical Trial ◽  
Dry Eye ◽  
Dry Eye Syndrome

scholarly journals Effects of a Combination of Foeniculum vulgare, Melissa officinalis Extract, and Nigella saliva Powder on Healthy Menopausal Women with Sexual Dysfunction: A Randomized Clinical Trial

2020 ◽  
Vol 15 (3) ◽  
Author(s):  
Shima Afshar ◽  
Fariba Afshar ◽  
Amir Rezazade ◽  
Zeinab Shaker Ardakani ◽  
Zahra Jafari Azar ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Sexual Dysfunction ◽  
Sexual Function ◽  
Postmenopausal Women ◽  
Randomized Clinical Trial ◽  
Nigella Sativa ◽  
Melissa Officinalis ◽  
Foeniculum Vulgare ◽  
Menopausal Women ◽  
Nigella Sativa Seed

Background: Menopause is a critical period with frequent sexual disorders. Objectives: The current study assessed the therapeutic effect of a combination of the aerial part of Melissa officinalis, fennel fruit extract, and Nigella sativa seed powder on the sexual dysfunction of postmenopausal women. Methods: This randomized clinical trial was performed on 48 menopausal women from April 2015 to October 2017. The participants included the menopausal women referring to the clinic of Gorgan health centers aged between 41 and 54 years with natural menopause (amenorrhea for at least 12 months) and discomfort in sexual activity. They were randomized into two treatment groups. Group 1 (n = 27) received 1000 mg capsules (Melissa officinalis, fennel extract, and Nigella sativa powder), and group 2 (n = 21) received a placebo (1000 mg starch capsules (in an eight-week course of treatment (one capsule per day for each group). The variables in the female sexual function index (FSFI) questionnaire were compared in the two groups before and after the intervention. Results: The results showed that the mean scores of sexual dysfunction in the domains of arousal, lubrication, orgasm, satisfaction, and pain were not significantly different between the two groups (P > 0.05). Conclusions: Despite many studies on the effectiveness of Melissa, Foenculum, and Nigella, this study showed that a combination of Foeniculum vulgare, Melissa officinalis extract, and Nigella sativa seed powder does not improve the sexual function of postmenopausal women with sexual dysfunction, and it might be the synergism effect of this combination.

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