Gastrodia elata Blume water extract modulates neurotransmitters and alters the gut microbiota in a mild social defeat stress‐induced depression mouse model

2021 ◽  
Author(s):  
Yun‐Ju Huang ◽  
Le‐Xin Chrystal Choong ◽  
Suraphan Panyod ◽  
Yu‐En Lin ◽  
Huai‐Syuan Huang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Gut Microbiota ◽  
Water Extract ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Gastrodia Elata ◽  
Gastrodia Elata Blume

scholarly journals Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress

2020 ◽  
Vol 21 (24) ◽  
pp. 9612
Author(s):  
Yasuhisa Ano ◽  
Shiho Kitaoka ◽  
Rena Ohya ◽  
Keiji Kondo ◽  
Tomoyuki Furuyashiki
Keyword(s):  
Mouse Model ◽  
Chronic Administration ◽  
Social Defeat ◽  
Underlying Mechanism ◽  
Mental Illnesses ◽  
Social Avoidance ◽  
Social Defeat Stress ◽  
Dopaminergic Activity ◽  
Healthy Older Adults ◽  
Bitter Acids

As daily lifestyle is closely associated with mental illnesses, diet-based preventive approaches are receiving attention. Supplementation with hop bitter acids such as iso-α-acids (IAA) and mature hop bitter acids (MHBA) improves mood states in healthy older adults. However, the underlying mechanism remains unknown. Since acute oral consumption with IAA increases dopamine levels in hippocampus and improves memory impairment via vagal nerve activation, here we investigated the effects of chronic administration of hop bitter acids on the dopaminergic activity associated with emotional disturbance in a mouse model of repeated social defeat stress (R-SDS). Chronic administration of IAA and MHBA significantly increased dopaminergic activity based on the dopamine metabolite to dopamine ratio in the hippocampus and medial prefrontal cortex following R-SDS. Hippocampal dopaminergic activity was inversely correlated with the level of R-SDS-induced social avoidance with or without IAA administration. Therefore, chronic treatment with hop bitter acids enhances stress resilience-related hippocampal dopaminergic activity.

The effects of emotional stress are not identical to those of physical stress in mouse model of social defeat stress

2020 ◽  
Vol 158 ◽  
pp. 56-63 ◽  
Author(s):  
Yuko Nakatake ◽  
Hiroki Furuie ◽  
Misa Yamada ◽  
Hiroshi Kuniishi ◽  
Masatoshi Ukezono ◽  
...  
Keyword(s):  
Mouse Model ◽  
Emotional Stress ◽  
Social Defeat ◽  
Physical Stress ◽  
Social Defeat Stress

Preventive effect of a Kampo medicine, kososan, on recurrent depression in a mouse model of repeated social defeat stress

Gene ◽  
2021 ◽  
pp. 145920
Author(s):  
Naoki Ito ◽  
Kazunori Sasaki ◽  
Eiji Hirose ◽  
Takayuki Nagai ◽  
Hiroko Isoda ◽  
...  
Keyword(s):  
Mouse Model ◽  
Social Defeat ◽  
Kampo Medicine ◽  
Preventive Effect ◽  
Recurrent Depression ◽  
Social Defeat Stress

scholarly journals Bifidobacterium in the gut microbiota confer resilience to chronic social defeat stress in mice

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Chun Yang ◽  
Yuko Fujita ◽  
Qian Ren ◽  
Min Ma ◽  
Chao Dong ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Chronic Social Defeat Stress

scholarly journals Water Extract of Gastrodia Elate Blume May Ameliorate Subchronic and Mild Social Defeat Stress-induced Behavior Through Gut-brain Axis in Mice (P14-018-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Chrystal Choong Le Xin ◽  
Lin Yu-En ◽  
Lu Kuan-Hung ◽  
Suraphan Panyod ◽  
Wu Wei-Kai ◽  
...  
Keyword(s):  
Amphotericin B ◽  
High Performance ◽  
Water Extract ◽  
Social Defeat ◽  
Stress Index ◽  
Social Avoidance ◽  
Social Defeat Stress ◽  
Stress Indicator ◽  
Funding Sources ◽  
The Impact

Abstract Objectives Gut has been known as the second brain and affects the brain via various pathways such as neurotransmitter modulation. We previously showed that water extract of Gastrodia elate Blume (WGE) exerts antidepression-like effect in forced swimming test. However, the impact of WGE on gut in subchronic and mild social defeat stress (sCSDS) model has not studied. Thus, we investigate the potential gut-brain linked mechanisms of WGE in relieving stress-induced depression-like behaviors which may result from the tryptophan (TRP) metabolism in mice subjected to sCSDS model. Methods C57/BL6J mice were divided into 6 groups: control (CTR), control with antibiotics (CTR + A), sCSDS, sCSDS with WGE (sCSDS + WGE), sCSDS with antibiotics (sCSDS + A) and sCSDS with antibiotics and WGE (sCSDS + A + WGE). Mice were administered 500 mg/kg body weight (BW) of WGE for 30 days and antibiotics by 10 ml/kg BW (0.1 mg/ml amphotericin B for the first 2 days, and then mixed with 5 mg/ml vancomycin, 10 mg/ml neomycin, 10 mg/ml metronidazol and 0.1 mg/ml amphotericin B for the next 28 days by gavage with ampicillin 1 mg/ml in drinking water), otherwise the sCSDS paradigm for 10 days, exclude the CTR groups. A social interaction test was conducted to assess the antidepression-like effects, while serum corticosterone (CORT) was tested as a stress indicator. Brain was isolated to dissect the TRP metabolism by using high performance liquid chromatography with electrochemical detection (HPLC-ECD). Results WGE significantly reversed the depression-like phenotypes, such as BW loss, social avoidance and stress index, serum CORT induced by sCSDS (P < 0.05). Whereas antibiotics administration elevated BW (P < 0.05). Treatment with antibiotics and WGE significantly increased social avoidance (P < 0.05). HPLC-ECD indicated WGE slightly normalized the 5-hydroxyindoleacetic acid (5-HIAA)/serotonin (5-HT) ratio, while antibiotics significantly decreased it, also significantly increased 5-HT and 5-HT/TRP ratio in prefrontal cortex (P < 0.05). In general, high levels of 5-HT in brain induced by sCSDS with antibiotics may linked to aggression, while WGE treatment reverse it. Conclusions The antidepression-like effects of WGE might be mediated by the regulation of TRP metabolism in gut-brain axis suggested to be a potential pathway to prevent depression. Funding Sources N/A. Supporting Tables, Images and/or Graphs

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