5,7‐Dimethoxyflavone induces apoptotic cell death in human endometriosis cell lines by activating the endoplasmic reticulum stress pathway

2020 ◽  
Vol 34 (9) ◽  
pp. 2275-2286
Author(s):  
Wonhyoung Park ◽  
Min Young Park ◽  
Gwonhwa Song ◽  
Whasun Lim
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Endoplasmic Reticulum Stress ◽  
Cell Lines ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Endoplasmic Reticulum Stress Pathway ◽  
Stress Pathway

scholarly journals Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP106–126

2007 ◽  
Vol 0 (0) ◽  
pp. 071108171001003-??? ◽  
Author(s):  
Elisabete Ferreiro ◽  
Rui Costa ◽  
Sueli Marques ◽  
Sandra Morais Cardoso ◽  
Catarina R. Oliveira ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Endoplasmic Reticulum Stress ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Cell Death Pathway

scholarly journals p53-Independent Endoplasmic Reticulum Stress-Mediated Cytotoxicity of a Newcastle Disease Virus Strain in Tumor Cell Lines

2007 ◽  
Vol 81 (6) ◽  
pp. 2817-2830 ◽  
Author(s):  
Zsolt Fábián ◽  
Christine M. Csatary ◽  
József Szeberényi ◽  
Laszlo K. Csatary
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Endoplasmic Reticulum Stress ◽  
Tumor Cell ◽  
Newcastle Disease Virus ◽  
Cell Lines ◽  
Newcastle Disease ◽  
Apoptotic Cell ◽  
Transformed Cells ◽  
Tumor Cell Lines

ABSTRACT While Newcastle disease virus (NDV) causes serious infections in birds, it is apparently nonpathogenic in mammalian species, including humans. Previous observations and small-scale clinical trials indicated that NDV exerts oncolytic effects. Isolates of NDV were found to have selective affinity to transformed cells. We previously showed that the attenuated NDV strain MTH-68/H causes apoptotic cell death in cultures of PC12 rat pheochromocytoma cells. The aim of the present study was to extend MTH-68/H cytotoxicity testing with human tumor cell lines and to analyze certain biochemical aspects of its oncolytic effect. MTH-68/H was found to be able to kill a wide range of transformed cells by apoptosis. While caspase-8 and caspase-9 are not involved in MTH-68/H-induced apoptosis, activation of caspase-3 and caspase-12 was detected in virus-infected PC12 cells. A human glioblastoma cell line with repressible expression of the p53 protein did not show any difference in MTH-68/H sensitivity in its p53-expressing and p53-depleted states, indicating that the apoptotic process induced by MTH-68/H does not depend on p53. Apoptosis was accompanied by virus replication in two tumor cell lines tested (PC12 cells and HeLa human cervical cells), and signs of endoplasmic reticulum stress (phosphorylation of protein kinase R-like endoplasmic reticulum kinase and eIF2α) were also detected in transformed cells. In contrast, proliferation of nontransformed mouse and rat fibroblast cell lines and human primary fibroblasts was not affected by MTH-68/H treatment. MTH-68/H thus selectively kills tumor cell cultures by inducing endoplasmic reticulum stress leading to p53-independent apoptotic cell death.

scholarly journals Cystathionine Protects against Endoplasmic Reticulum Stress-induced Lipid Accumulation, Tissue Injury, and Apoptotic Cell Death

2012 ◽  
Vol 287 (38) ◽  
pp. 31994-32005 ◽  
Author(s):  
Kenneth N. Maclean ◽  
Lori S. Greiner ◽  
Jeffrey R. Evans ◽  
Sudesh K. Sood ◽  
Sarka Lhotak ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Endoplasmic Reticulum Stress ◽  
Lipid Accumulation ◽  
Tissue Injury ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death

2016 ◽  
Vol 50 (12) ◽  
pp. 1408-1421 ◽  
Author(s):  
Jeong Su Park ◽  
Sue Young Oh ◽  
Da Hyun Lee ◽  
Yu Seol Lee ◽  
Su Haeng Sung ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Endoplasmic Reticulum Stress ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death
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