scholarly journals Plant‐derived glucose transport inhibitors with potential antitumor activity

2019 ◽  
Vol 34 (5) ◽  
pp. 1027-1040 ◽  
Author(s):  
Pratik Shriwas ◽  
Xiaozhuo Chen ◽  
A. Douglas Kinghorn ◽  
Yulin Ren
Keyword(s):  
Antitumor Activity ◽  
Glucose Transport ◽  
Transport Inhibitors ◽  
Potential Antitumor

Application of a Validated QSTR Model for Repurposing COX-2 Inhibitor Coumarin Derivatives as Potential Antitumor Agents

2019 ◽  
Vol 19 (13) ◽  
pp. 1121-1128 ◽  
Author(s):  
Gulcin Tugcu ◽  
Hande Sipahi ◽  
Ahmet Aydin
Keyword(s):  
Antitumor Activity ◽  
Drug Development ◽  
Linear Model ◽  
Cell Lines ◽  
Cyclooxygenase 2 ◽  
Large Set ◽  
Coumarin Derivatives ◽  
Antitumor Compounds ◽  
Cyclooxygenase 2 Inhibitors ◽  
Potential Antitumor

Background: The discovery of novel potent molecules for both cancer prevention and treatment has been continuing over the past decade. In recent years, identification of new, potent, and safe anticancer agents through drug repurposing has been regarded as an expeditious alternative to traditional drug development. The cyclooxygenase-2 is known to be over-expressed in several types of human cancer. For this reason cyclooxygenase-2 inhibition may be useful tool for cancer chemotherapy. Objective: The first aim of the study was to develop a validated linear model to predict antitumor activity. Subsequently, applicability of the model for repurposing these cyclooxygenase-2 inhibitors as antitumor compounds to abridge drug development process. Method: We performed a quantitative structure-toxicity relationship (QSTR) study on a set of coumarin derivatives using a large set of molecular descriptors. A linear model predicting growth inhibition on leukemia CCRF cell lines was developed and consequently validated internally and externally. Accordingly, the model was applied on a set of 143 cyclooxygenase-2 inhibitor coumarin derivatives to explore their antitumor activity. Results: The results indicated that the developed QSAR model would be useful for estimating inhibitory activity of coumarin derivatives on leukemia cell lines. Electronegativity was found to be a prominent property of the molecules in describing antitumor activity. The applicability domain of the developed model highlighted the potential antitumor compounds. Conclusion: The promising results revealed that applied integrated in silico approach for repurposing by combining both the biological activity similarity and the molecular similarity via the computational method could be efficiently used to screen potential antitumor compounds among cyclooxygenase-2 inhibitors.

scholarly journals Potential Antitumor Activity of SIM-89 in Non-Small Cell Lung Cancer Cells

2017 ◽  
Vol 58 (3) ◽  
pp. 581
Author(s):  
Jun Pei ◽  
Tianqing Chu ◽  
Minhua Shao ◽  
Jiajun Teng ◽  
Huifang Sha ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Antitumor Activity ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung ◽  
Potential Antitumor

scholarly journals Conjugation of DM1 to anti-CD30 antibody has potential antitumor activity in CD30-positive hematological malignancies with lower systemic toxicity

mAbs ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1149-1161 ◽  
Author(s):  
Yijun Shen ◽  
Tong Yang ◽  
Xuemei Cao ◽  
Yifan Zhang ◽  
Li Zhao ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Hematological Malignancies ◽  
Systemic Toxicity ◽  
Potential Antitumor

ChemInform Abstract: Partial Synthesis of Some Diterpenoids with Potential Antitumor Activity.

ChemInform ◽  
2010 ◽  
Vol 23 (9) ◽  
pp. no-no
Author(s):  
M. S. ALI ◽  
M. K. BAYNHAM ◽  
J. R. HANSON ◽  
P. B. HITCHCOCK
Keyword(s):  
Antitumor Activity ◽  
Partial Synthesis ◽  
Potential Antitumor
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