Chrysophanol attenuates airway inflammation and remodeling through nuclear factor‐kappa B signaling pathway in asthma

2019 ◽  
Vol 33 (10) ◽  
pp. 2702-2713 ◽  
Author(s):  
Guihua Song ◽  
Yan Zhang ◽  
Suping Yu ◽  
Weigang Lv ◽  
Zhiwei Guan ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Signaling Pathway ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

The nuclear factor kappa-B signaling pathway as a therapeutic target against thyroid cancers

Thyroid ◽  
2012 ◽  
pp. 120813190527004 ◽  
Author(s):  
Xinying Li ◽  
Asim B Abdel-Mageed ◽  
Debasis Mondal ◽  
Emad Kandil
Keyword(s):  
Signaling Pathway ◽  
Therapeutic Target ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Thyroid Cancers ◽  
Nuclear Factor Kappa

scholarly journals Role of Nuclear Factor Kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach

2020 ◽  
Vol 18 (10) ◽  
pp. 918-935 ◽  
Author(s):  
Shareen Singh ◽  
Thakur Gurjeet Singh
Keyword(s):  
Neurodegenerative Diseases ◽  
Signaling Pathway ◽  
Nuclear Factor Kappa B ◽  
Autoimmune Disorder ◽  
Nuclear Factor ◽  
Human Beings ◽  
Inhibitor Molecule ◽  
Nuclear Factor Kappa ◽  
Iκb Kinase

A transcriptional regulatory nuclear factor kappa B (NF-κB) protein is a modulator of cellular biological activity via binding to a promoter region in the nucleus and transcribing various protein genes. The recent research implicated the intensive role of nuclear factor kappa B (NF-κB) in diseases like autoimmune disorder, inflammatory, cardiovascular and neurodegenerative diseases. Therefore, targeting the nuclear factor kappa B (NF-κB) protein offers a new opportunity as a therapeutic approach. Activation of IκB kinase/NF-κB signaling pathway leads to the development of various pathological conditions in human beings, such as neurodegenerative, inflammatory disorders, autoimmune diseases, and cancer. Therefore, the transcriptional activity of IκB kinase/NF- κB is strongly regulated at various cascade pathways. The nuclear factor NF-kB pathway plays a major role in the expression of pro-inflammatory genes, including cytokines, chemokines, and adhesion molecules. In response to the diverse stimuli, the cytosolic sequestered NF-κB in an inactivated form by binding with an inhibitor molecule protein (IkB) gets phosphorylated and translocated into the nucleus further transcribing various genes necessary for modifying various cellular functions. The various researches confirmed the role of different family member proteins of NF-κB implicated in expressing various genes products and mediating various cellular cascades. MicroRNAs, as regulators of NF- κB microRNAs play important roles in the regulation of the inflammatory process. Therefore, the inhibitor of NF-κB and its family members plays a novel therapeutic target in preventing various diseases. Regulation of NF- κB signaling pathway may be a safe and effective treatment strategy for various disorders.

Asiaticoside Regulates Toll-Like Receptor 4/Nuclear Factor-Kappa B Signaling Pathway to Relieve Lipopolysccharide-Induced Inflammation and Apoptosis in ATDC5 Cells

2021 ◽  
Vol 19 (4) ◽  
pp. 432-437
Author(s):  
Lin Gao ◽  
Ming Yang ◽  
San Cai ◽  
Liping Gao ◽  
Chunfeng Gui ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Nuclear Factor Kappa B ◽  
Centella Asiatica ◽  
Joint Disease ◽  
Therapeutic Drug ◽  
Nuclear Factor ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Nuclear Factor Kappa ◽  
Bioactive Component

Osteoarthritis is a progressive joint disease characterized by degeneration and destruction of articular cartilage. The incidence of osteoarthritis has increased steadily over the years leading to more than 50% in people over the age of 65. Due to associated side effects of prevailing therapeutics, better drugs are needed for osteoarthritis management. Asiaticoside is a bioactive component isolated from the medicinal plant Centella asiatica. It has been reported to possess neuroprotective, antiulcer, wound healing, anti-inflammatory, antioxidative, and other pharmacological properties. However, the potential of asiaticoside in the management of osteoarthritis remains to be explored. To this end, we examined the effect of asiaticoside on lipopolysaccharides induced inflammatory injury and apoptosis of chondrocytes. The results show that asiaticoside promotes viability and decrease in apoptosis of ATDC5 cells through decreased production of proinflammatory cytokines and the regulation of toll-like receptor 4/nuclear factor-kappa b signaling pathway. In summary, our results provide the evidence that asiaticoside could serve as a promising therapeutic drug for osteoarthritis treatment.

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