Boswellic acid has anti‐inflammatory effects and enhances the anticancer activities of Temozolomide and Afatinib, an irreversible ErbB family blocker, in human glioblastoma cells

2019 ◽  
Vol 33 (6) ◽  
pp. 1670-1682 ◽  
Author(s):  
Manlio Barbarisi ◽  
Alfonso Barbarisi ◽  
Gabriele De Sena ◽  
Emilia Armenia ◽  
Caterina Aurilio ◽  
...  
Keyword(s):  
Boswellic Acid ◽  
Glioblastoma Cells ◽  
Anticancer Activities ◽  
Human Glioblastoma ◽  
Erbb Family ◽  
Erbb Family Blocker ◽  
Human Glioblastoma Cells ◽  
Anti Inflammatory

scholarly journals Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains

1997 ◽  
Vol 94 (7) ◽  
pp. 3250-3255 ◽  
Author(s):  
D. M. O'Rourke ◽  
X. Qian ◽  
H.-T. Zhang ◽  
J. G. Davis ◽  
E. Nute ◽  
...  
Keyword(s):  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Erbb Family ◽  
Receptor Inhibition ◽  
Human Glioblastoma Cells

Nonsteroidal Anti-inflammatory Drugs Diclofenac and Celecoxib Attenuates Wnt/β-Catenin/Tcf Signaling Pathway in Human Glioblastoma Cells

2013 ◽  
Vol 38 (11) ◽  
pp. 2313-2322 ◽  
Author(s):  
Gangadhara Reddy Sareddy ◽  
Divya Kesanakurti ◽  
Puligurtha Bharadhwaja Kirti ◽  
Phanithi Prakash Babu
Keyword(s):  
Signaling Pathway ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Inflammatory Drugs ◽  
Human Glioblastoma Cells ◽  
Anti Inflammatory

Anticancer effects of novel NSAIDs derivatives on cultured human glioblastoma cells

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Özlem Özdemir ◽  
Lisa Marinelli ◽  
Ivana Cacciatore ◽  
Michele Ciulla ◽  
Bugrahan Emsen ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Suppressor Gene ◽  
Pcr Analysis ◽  
Control Group ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Inflammatory Drugs ◽  
Human Glioblastoma Cells ◽  
Anti Inflammatory ◽  
Prevention Of Cancer

AbstractSeveral epidemiologic, clinical and experimental reports indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) could have a potential as anticancer agents. The aim of this study was the evaluation of cytotoxic potential in human glioblastoma cells of novel synthesized NSAID derivatives, obtained by linking, through a spacer, α-lipoic acid (ALA) to anti-inflammatory drugs, such as naproxen (AL-3, 11 and 17), flurbiprofen (AL-6, 13 and 19) and ibuprofen (AL-9, 15 and 21). The effects on the level of gene expression were also determined using quantitative real-time polymerase chain reaction (qRT-PCR) analysis. According to our results, NSAID derivatives exhibited concentration dependent cytotoxic effects on U87-MG cell line when compared with the control group. Moreover, treatment of the most active compounds (AL-3, AL-6 and AL-9) caused upregulation of tumor suppressor gene PTEN and downregulation of some oncogenes such as AKT1, RAF1 and EGFR. In conclusion, our results revealed that AL-3, AL-6 and AL-9 could be suitable candidates for further investigation to develop new pharmacological strategies for the prevention of cancer.

scholarly journals Olaparib Is a Mitochondrial Complex I Inhibitor That Kills Temozolomide-Resistant Human Glioblastoma Cells

2021 ◽  
Vol 22 (21) ◽  
pp. 11938
Author(s):  
Luca X. Zampieri ◽  
Martina Sboarina ◽  
Andrea Cacace ◽  
Debora Grasso ◽  
Léopold Thabault ◽  
...  
Keyword(s):  
Complex I ◽  
Dna Methyltransferase ◽  
Parp Inhibitor ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex ◽  
Glioblastoma Cells ◽  
Anticancer Activities ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells ◽  
Mitochondrial Complex I Inhibitor

Glioblastoma represents the highest grade of brain tumors. Despite maximal resection surgery associated with radiotherapy and concomitant followed by adjuvant chemotherapy with temozolomide (TMZ), patients have a very poor prognosis due to the rapid recurrence and the acquisition of resistance to TMZ. Here, initially considering that TMZ is a prodrug whose activation is pH-dependent, we explored the contribution of glioblastoma cell metabolism to TMZ resistance. Using isogenic TMZ-sensitive and TMZ-resistant human glioblastoma cells, we report that the expression of O6-methylguanine DNA methyltransferase (MGMT), which is known to repair TMZ-induced DNA methylation, does not primarily account for TMZ resistance. Rather, fitter mitochondria in TMZ-resistant glioblastoma cells are a direct cause of chemoresistance that can be targeted by inhibiting oxidative phosphorylation and/or autophagy/mitophagy. Unexpectedly, we found that PARP inhibitor olaparib, but not talazoparib, is also a mitochondrial Complex I inhibitor. Hence, we propose that the anticancer activities of olaparib in glioblastoma and other cancer types combine DNA repair inhibition and impairment of cancer cell respiration.

scholarly journals Jinlong capsule inhibits migration and invasion in human glioblastoma cells via the modulation of mTOR/S6 signaling pathway

2019 ◽  
Vol Volume 13 ◽  
pp. 1023-1032 ◽  
Author(s):  
Jingren Shi ◽  
Wenli Zhang ◽  
Lu He ◽  
Fanhong Kong ◽  
Meichen Pan ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Migration And Invasion ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells

The cytotoxicity of high-linear energy transfer radiation is reinforced by oxaliplatin in human glioblastoma cells

2007 ◽  
Vol 254 (1) ◽  
pp. 54-62 ◽  
Author(s):  
Sami Benzina ◽  
Frederic Debomy ◽  
Jean-Pierre Bergerat ◽  
Jean-Marc Denis ◽  
John Gueulette ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Linear Energy Transfer ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells ◽  
Linear Energy Transfer Radiation ◽  
High Linear Energy Transfer

Olea europaea leaf extract alters microRNA expression in human glioblastoma cells

2012 ◽  
Vol 138 (11) ◽  
pp. 1831-1844 ◽  
Author(s):  
Berrin Tunca ◽  
Gulcin Tezcan ◽  
Gulsah Cecener ◽  
Unal Egeli ◽  
Secil Ak ◽  
...  
Keyword(s):  
Olea Europaea ◽  
Leaf Extract ◽  
Microrna Expression ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells ◽  
Olea Europaéa
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