Polar Quassinoids in Standardized Eurycoma longifolia Extract Formulated into a Lipid-Based Solid Dispersion to Improve Rat Sperm Count

2017 ◽  
Vol 31 (12) ◽  
pp. 1875-1882 ◽  
Author(s):  
Hai-Qiu Ma ◽  
Forough Ebrahimi ◽  
Bin-Seng Low ◽  
Nurzalina Abdul Karim Khan ◽  
Kit-Lam Chan
Keyword(s):  
Solid Dispersion ◽  
Sperm Count ◽  
Eurycoma Longifolia

423. Effects of Eurycoma longifolia Jack on spermatogenesis and sperm counts of male rats treated with oestradiol

2008 ◽  
Vol 20 (9) ◽  
pp. 103
Author(s):  
A. Norhazlina ◽  
A. Wan Nurul Heriza ◽  
M. Norfilza ◽  
P. Moratv
Keyword(s):  
Cell Count ◽  
Sperm Count ◽  
Treated Group ◽  
Spermatogenic Cell ◽  
Male Rats ◽  
Control Group ◽  
Root Extract ◽  
Healthy Male ◽  
Eurycoma Longifolia ◽  
Sperm Counts

Eurycoma longifolia has been known for its aphrodisiac effects in male. Our previous study showed that with the dosage of 8 mg/kg bodyweight (BW) Eurycoma longifolia root extract increased plasma total testosterone levels in male rats when given for 14 days. Oestrogen is a potent inhibitor for testosterone production and spermatogenesis. The aim of the present study is to determine the effects of Eurycoma longifolia (8 mg/kg BW) on the spermatogenic cell count and sperm count of testosterone-suppressed male rats. Adult male Sprague-Dawley healthy male rats weighed 200–250 g were treated with, either control vehicle (no active ingredients given), oestradiol (500 mg/kg BW), Eurycoma longifolia (8 mg/kg BW) or combination of Eurycoma longifolia and oestradiol for fourteen consecutive days. Results showed that sperm count and spermatogenic cell count were increased in Eurycoma longifolia treated group compared with control group (P < 0.05) and to oestradiol treated group (P < 0.05). While in oestradiol treated group, sperm count and spermatogenic cell count were reduced significantly (P < 0.05) compared with control group. Combination of Eurycoma longifolia and oestradiol did not affect sperm count and spermatogenic cell count when compared with control group but they were significantly increased compared with oestradiol treated group (P < 0.05). Thus, the study has shown that Eurycoma longifolia is potentially capable to suppress harmful effects of oestradiol on spermatogenesis and sperm counts in healthy male rats when given for fourteen consecutive days.

Urinary NMR-based metabolomic analysis of rats possessing variable sperm count following orally administered Eurycoma longifolia extracts of different quassinoid levels

2016 ◽  
Vol 182 ◽  
pp. 80-89 ◽  
Author(s):  
Forough Ebrahimi ◽  
Baharudin Ibrahim ◽  
Chin-Hoe Teh ◽  
Vikneswaran Murugaiyah ◽  
Kit-Lam Chan
Keyword(s):  
Sperm Count ◽  
Metabolomic Analysis ◽  
Eurycoma Longifolia

The absorption characteristics of bifendate solid dispersion in rat intestinal tissue

2009 ◽  
Vol 00 (00) ◽  
pp. 090810023429058-9
Author(s):  
Juan Cheng ◽  
Zheng Hong Wu ◽  
Qineng Neng Ping ◽  
Bogang Wang ◽  
Junjun Lu
Keyword(s):  
Solid Dispersion ◽  
Intestinal Tissue ◽  
Absorption Characteristics

Antimicrobial activity of Eurycoma longifolia and Momordica charantia

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
R Łos ◽  
K Skalicka-Wozniak ◽  
J Widelski ◽  
A Malm ◽  
K Głowniak
Keyword(s):  
Antimicrobial Activity ◽  
Momordica Charantia ◽  
Eurycoma Longifolia

Solid dispersion of valsartan for solubility improvement using β-cyclodextrin

2018 ◽  
Vol 5 (6) ◽  
Author(s):  
Sapkal SB ◽  
Shinde SA ◽  
Darakhe RA ◽  
Shrikhande VN
Keyword(s):  
Solid Dispersion ◽  
Solubility Improvement

Effect of new dietary supplement on sperm quality

2012 ◽  
Vol 153 (45) ◽  
pp. 1787-1792 ◽  
Author(s):  
Mária Horváth ◽  
Endre Czeizel
Keyword(s):  
Adverse Effect ◽  
Clinical Trial ◽  
Dietary Supplement ◽  
Male Fertility ◽  
Sperm Quality ◽  
Sperm Count ◽  
Before And After ◽  
The Usa ◽  
New Treatments

Introduction: There is a decline in male fertility thus new treatments are needed. Aims: To test the efficacy of a new dietary supplement developed in the USA and registered as a curing drug in Hungary (OGYI). Methods: In a clinical trial 100 men with low sperm quality (spermium count 5–20 M/ml, good motility 10–40%, and adverse shape 30–50%) were examined. Results: Sperm parameters were measured before and after a 3-month treatment and after another 3-month without treatment. This dietary supplement statistically and clinically significantly improved sperm count and motility. In 74 cases this dietary supplement demonstrated a beneficial effect on sperm quality (more than 10% increase in sperm count, or quality of motility, or shape); in 16 cases the improvement exceeded 30%. No adverse effect could be accounted for this treatment. Conclusions: This new dietary supplement may contribute to the treatment of male infertility. Orv. Hetil., 2012, 153, 1787–1792.

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